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30  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: BRCA1_HUMAN (P38398)

Summary

This is the summary of UniProt entry BRCA1_HUMAN (P38398).

Description: Breast cancer type 1 susceptibility protein
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1863 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam zf-C3HC4 24 64
disorder n/a 135 153
disorder n/a 163 168
disorder n/a 176 184
disorder n/a 191 195
disorder n/a 202 204
disorder n/a 207 216
disorder n/a 218 221
disorder n/a 227 293
disorder n/a 301 346
Pfam BRCT_assoc 345 508
disorder n/a 353 367
disorder n/a 371 373
disorder n/a 390 410
low_complexity n/a 394 405
disorder n/a 426 428
disorder n/a 443 444
disorder n/a 494 629
low_complexity n/a 533 544
disorder n/a 631 632
disorder n/a 636 643
low_complexity n/a 643 654
disorder n/a 647 706
disorder n/a 708 709
disorder n/a 713 714
disorder n/a 718 776
low_complexity n/a 729 736
disorder n/a 782 783
disorder n/a 786 789
disorder n/a 816 821
disorder n/a 825 851
disorder n/a 856 857
disorder n/a 868 870
disorder n/a 872 873
disorder n/a 880 881
disorder n/a 883 887
disorder n/a 896 920
disorder n/a 927 932
disorder n/a 964 972
disorder n/a 1000 1027
disorder n/a 1030 1032
disorder n/a 1034 1035
disorder n/a 1037 1076
disorder n/a 1080 1081
disorder n/a 1095 1116
disorder n/a 1127 1165
disorder n/a 1185 1218
low_complexity n/a 1209 1223
disorder n/a 1242 1251
coiled_coil n/a 1253 1273
low_complexity n/a 1254 1268
disorder n/a 1277 1279
disorder n/a 1281 1282
disorder n/a 1308 1309
disorder n/a 1311 1505
coiled_coil n/a 1397 1424
low_complexity n/a 1425 1437
disorder n/a 1507 1508
disorder n/a 1512 1517
disorder n/a 1519 1559
disorder n/a 1563 1596
low_complexity n/a 1572 1587
disorder n/a 1601 1645
Pfam BRCT 1642 1723
disorder n/a 1647 1648
low_complexity n/a 1673 1686
transmembrane n/a 1701 1719
disorder n/a 1740 1741
disorder n/a 1745 1749
disorder n/a 1751 1752
Pfam BRCT 1756 1842

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P38398. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDLSALRVEE VQNVINAMQK ILECPICLEL IKEPVSTKCD HIFCKFCMLK
50
51
LLNQKKGPSQ CPLCKNDITK RSLQESTRFS QLVEELLKII CAFQLDTGLE
100
101
YANSYNFAKK ENNSPEHLKD EVSIIQSMGY RNRAKRLLQS EPENPSLQET
150
151
SLSVQLSNLG TVRTLRTKQR IQPQKTSVYI ELGSDSSEDT VNKATYCSVG
200
201
DQELLQITPQ GTRDEISLDS AKKAACEFSE TDVTNTEHHQ PSNNDLNTTE
250
251
KRAAERHPEK YQGSSVSNLH VEPCGTNTHA SSLQHENSSL LLTKDRMNVE
300
301
KAEFCNKSKQ PGLARSQHNR WAGSKETCND RRTPSTEKKV DLNADPLCER
350
351
KEWNKQKLPC SENPRDTEDV PWITLNSSIQ KVNEWFSRSD ELLGSDDSHD
400
401
GESESNAKVA DVLDVLNEVD EYSGSSEKID LLASDPHEAL ICKSERVHSK
450
451
SVESNIEDKI FGKTYRKKAS LPNLSHVTEN LIIGAFVTEP QIIQERPLTN
500
501
KLKRKRRPTS GLHPEDFIKK ADLAVQKTPE MINQGTNQTE QNGQVMNITN
550
551
SGHENKTKGD SIQNEKNPNP IESLEKESAF KTKAEPISSS ISNMELELNI
600
601
HNSKAPKKNR LRRKSSTRHI HALELVVSRN LSPPNCTELQ IDSCSSSEEI
650
651
KKKKYNQMPV RHSRNLQLME GKEPATGAKK SNKPNEQTSK RHDSDTFPEL
700
701
KLTNAPGSFT KCSNTSELKE FVNPSLPREE KEEKLETVKV SNNAEDPKDL
750
751
MLSGERVLQT ERSVESSSIS LVPGTDYGTQ ESISLLEVST LGKAKTEPNK
800
801
CVSQCAAFEN PKGLIHGCSK DNRNDTEGFK YPLGHEVNHS RETSIEMEES
850
851
ELDAQYLQNT FKVSKRQSFA PFSNPGNAEE ECATFSAHSG SLKKQSPKVT
900
901
FECEQKEENQ GKNESNIKPV QTVNITAGFP VVGQKDKPVD NAKCSIKGGS
950
951
RFCLSSQFRG NETGLITPNK HGLLQNPYRI PPLFPIKSFV KTKCKKNLLE
1000
1001
ENFEEHSMSP EREMGNENIP STVSTISRNN IRENVFKEAS SSNINEVGSS
1050
1051
TNEVGSSINE IGSSDENIQA ELGRNRGPKL NAMLRLGVLQ PEVYKQSLPG
1100
1101
SNCKHPEIKK QEYEEVVQTV NTDFSPYLIS DNLEQPMGSS HASQVCSETP
1150
1151
DDLLDDGEIK EDTSFAENDI KESSAVFSKS VQKGELSRSP SPFTHTHLAQ
1200
1201
GYRRGAKKLE SSEENLSSED EELPCFQHLL FGKVNNIPSQ STRHSTVATE
1250
1251
CLSKNTEENL LSLKNSLNDC SNQVILAKAS QEHHLSEETK CSASLFSSQC
1300
1301
SELEDLTANT NTQDPFLIGS SKQMRHQSES QGVGLSDKEL VSDDEERGTG
1350
1351
LEENNQEEQS MDSNLGEAAS GCESETSVSE DCSGLSSQSD ILTTQQRDTM
1400
1401
QHNLIKLQQE MAELEAVLEQ HGSQPSNSYP SIISDSSALE DLRNPEQSTS
1450
1451
EKAVLTSQKS SEYPISQNPE GLSADKFEVS ADSSTSKNKE PGVERSSPSK
1500
1501
CPSLDDRWYM HSCSGSLQNR NYPSQEELIK VVDVEEQQLE ESGPHDLTET
1550
1551
SYLPRQDLEG TPYLESGISL FSDDPESDPS EDRAPESARV GNIPSSTSAL
1600
1601
KVPQLKVAES AQSPAAAHTT DTAGYNAMEE SVSREKPELT ASTERVNKRM
1650
1651
SMVVSGLTPE EFMLVYKFAR KHHITLTNLI TEETTHVVMK TDAEFVCERT
1700
1701
LKYFLGIAGG KWVVSYFWVT QSIKERKMLN EHDFEVRGDV VNGRNHQGPK
1750
1751
RARESQDRKI FRGLEICCYG PFTNMPTDQL EWMVQLCGAS VVKELSSFTL
1800
1801
GTGVHPIVVV QPDAWTEDNG FHAIGQMCEA PVVTREWVLD SVALYQCQEL
1850
1851
DTYLIPQIPH SHY                                        
1863
 

Show the unformatted sequence.

Checksums:
CRC64:89C6D83FF56312AF
MD5:e40f752dedf675e2f7c99142ebb2607a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
BRCT 1646 - 1723 1T2V B 1646 - 1723 Show 3D Structure View in InterPro
4IGK A 1646 - 1723 Show 3D Structure View in InterPro
B 1646 - 1723 Show 3D Structure View in InterPro
4U4A A 1646 - 1723 Show 3D Structure View in InterPro
B 1646 - 1723 Show 3D Structure View in InterPro
4Y18 A 1646 - 1723 Show 3D Structure View in InterPro
B 1646 - 1723 Show 3D Structure View in InterPro
C 1646 - 1723 Show 3D Structure View in InterPro
D 1646 - 1723 Show 3D Structure View in InterPro
E 1646 - 1723 Show 3D Structure View in InterPro
F 1646 - 1723 Show 3D Structure View in InterPro
4Y2G A 1646 - 1723 Show 3D Structure View in InterPro
6G2I H 1646 - 1723 Show 3D Structure View in InterPro
K 1646 - 1723 Show 3D Structure View in InterPro
M 1646 - 1723 Show 3D Structure View in InterPro
O 1646 - 1723 Show 3D Structure View in InterPro
S 1646 - 1723 Show 3D Structure View in InterPro
U 1646 - 1723 Show 3D Structure View in InterPro
W 1646 - 1723 Show 3D Structure View in InterPro
Y 1646 - 1723 Show 3D Structure View in InterPro
1647 - 1723 1T2V D 1647 - 1723 Show 3D Structure View in InterPro
3PXE A 1647 - 1723 Show 3D Structure View in InterPro
B 1647 - 1723 Show 3D Structure View in InterPro
C 1647 - 1723 Show 3D Structure View in InterPro
1648 - 1723 3COJ A 1648 - 1723 Show 3D Structure View in InterPro
B 1648 - 1723 Show 3D Structure View in InterPro
C 1648 - 1723 Show 3D Structure View in InterPro
G 1648 - 1723 Show 3D Structure View in InterPro
X 1648 - 1723 Show 3D Structure View in InterPro
4U4A C 1648 - 1723 Show 3D Structure View in InterPro
1649 - 1723 1JNX X 1649 - 1723 Show 3D Structure View in InterPro
1N5O X 1649 - 1723 Show 3D Structure View in InterPro
1T15 A 1649 - 1723 Show 3D Structure View in InterPro
1T29 A 1649 - 1723 Show 3D Structure View in InterPro
1T2U A 1649 - 1723 Show 3D Structure View in InterPro
1T2V A 1649 - 1723 Show 3D Structure View in InterPro
C 1649 - 1723 Show 3D Structure View in InterPro
E 1649 - 1723 Show 3D Structure View in InterPro
1Y98 A 1649 - 1723 Show 3D Structure View in InterPro
2ING X 1649 - 1723 Show 3D Structure View in InterPro
3COJ D 1649 - 1723 Show 3D Structure View in InterPro
E 1649 - 1723 Show 3D Structure View in InterPro
F 1649 - 1723 Show 3D Structure View in InterPro
3K0H A 1649 - 1723 Show 3D Structure View in InterPro
3K0K A 1649 - 1723 Show 3D Structure View in InterPro
3K15 A 1649 - 1723 Show 3D Structure View in InterPro
3K16 A 1649 - 1723 Show 3D Structure View in InterPro
3PXA A 1649 - 1723 Show 3D Structure View in InterPro
3PXB A 1649 - 1723 Show 3D Structure View in InterPro
3PXC X 1649 - 1723 Show 3D Structure View in InterPro
3PXD A 1649 - 1723 Show 3D Structure View in InterPro
3PXE D 1649 - 1723 Show 3D Structure View in InterPro
4IFI A 1649 - 1723 Show 3D Structure View in InterPro
4JLU A 1649 - 1723 Show 3D Structure View in InterPro
4OFB A 1649 - 1723 Show 3D Structure View in InterPro
4Y18 G 1649 - 1723 Show 3D Structure View in InterPro
H 1649 - 1723 Show 3D Structure View in InterPro
1756 - 1842 1JNX X 1756 - 1842 Show 3D Structure View in InterPro
1N5O X 1756 - 1842 Show 3D Structure View in InterPro
1OQA A 3 - 89 Show 3D Structure View in InterPro
1T15 A 1756 - 1842 Show 3D Structure View in InterPro
1T29 A 1756 - 1842 Show 3D Structure View in InterPro
1T2U A 1756 - 1842 Show 3D Structure View in InterPro
1T2V A 1756 - 1842 Show 3D Structure View in InterPro
B 1756 - 1842 Show 3D Structure View in InterPro
C 1756 - 1842 Show 3D Structure View in InterPro
D 1756 - 1842 Show 3D Structure View in InterPro
E 1756 - 1842 Show 3D Structure View in InterPro
1Y98 A 1756 - 1842 Show 3D Structure View in InterPro
2ING X 1756 - 1842 Show 3D Structure View in InterPro
3COJ A 1756 - 1842 Show 3D Structure View in InterPro
B 1756 - 1842 Show 3D Structure View in InterPro
C 1756 - 1842 Show 3D Structure View in InterPro
D 1756 - 1842 Show 3D Structure View in InterPro
E 1756 - 1842 Show 3D Structure View in InterPro
F 1756 - 1842 Show 3D Structure View in InterPro
G 1756 - 1842 Show 3D Structure View in InterPro
X 1756 - 1842 Show 3D Structure View in InterPro
3K0H A 1756 - 1842 Show 3D Structure View in InterPro
3K0K A 1756 - 1842 Show 3D Structure View in InterPro
3K15 A 1756 - 1842 Show 3D Structure View in InterPro
3K16 A 1756 - 1842 Show 3D Structure View in InterPro
3PXA A 1756 - 1842 Show 3D Structure View in InterPro
3PXB A 1756 - 1842 Show 3D Structure View in InterPro
3PXC X 1756 - 1842 Show 3D Structure View in InterPro
3PXD A 1756 - 1842 Show 3D Structure View in InterPro
3PXE A 1756 - 1842 Show 3D Structure View in InterPro
B 1756 - 1842 Show 3D Structure View in InterPro
C 1756 - 1842 Show 3D Structure View in InterPro
D 1756 - 1842 Show 3D Structure View in InterPro
4IFI A 1756 - 1842 Show 3D Structure View in InterPro
4IGK A 1756 - 1842 Show 3D Structure View in InterPro
B 1756 - 1842 Show 3D Structure View in InterPro
4JLU A 1756 - 1842 Show 3D Structure View in InterPro
4OFB A 1756 - 1842 Show 3D Structure View in InterPro
4U4A A 1756 - 1842 Show 3D Structure View in InterPro
B 1756 - 1842 Show 3D Structure View in InterPro
C 1756 - 1842 Show 3D Structure View in InterPro
4Y18 A 1756 - 1842 Show 3D Structure View in InterPro
B 1756 - 1842 Show 3D Structure View in InterPro
C 1756 - 1842 Show 3D Structure View in InterPro
D 1756 - 1842 Show 3D Structure View in InterPro
E 1756 - 1842 Show 3D Structure View in InterPro
F 1756 - 1842 Show 3D Structure View in InterPro
G 1756 - 1842 Show 3D Structure View in InterPro
H 1756 - 1842 Show 3D Structure View in InterPro
4Y2G A 1756 - 1842 Show 3D Structure View in InterPro
6G2I H 1756 - 1842 Show 3D Structure View in InterPro
K 1756 - 1842 Show 3D Structure View in InterPro
M 1756 - 1842 Show 3D Structure View in InterPro
O 1756 - 1842 Show 3D Structure View in InterPro
S 1756 - 1842 Show 3D Structure View in InterPro
U 1756 - 1842 Show 3D Structure View in InterPro
W 1756 - 1842 Show 3D Structure View in InterPro
Y 1756 - 1842 Show 3D Structure View in InterPro
zf-C3HC4 24 - 64 1JM7 A 24 - 64 Show 3D Structure View in InterPro
7JZV A 24 - 64 Show 3D Structure View in InterPro
7LYB M 24 - 64 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;