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8  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: IL6RB_HUMAN (P40189)

Summary

This is the summary of UniProt entry IL6RB_HUMAN (P40189).

Description: Interleukin-6 receptor subunit beta
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 918 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 22
Pfam Lep_receptor_Ig 26 112
Pfam IL6Ra-bind 131 218
Pfam fn3 223 311
disorder n/a 270 272
disorder n/a 511 517
Pfam fn3 518 605
disorder n/a 523 527
transmembrane n/a 621 641
low_complexity n/a 624 639
disorder n/a 660 681
low_complexity n/a 722 754
disorder n/a 725 764
disorder n/a 773 803
disorder n/a 810 836
disorder n/a 839 840
disorder n/a 842 844
disorder n/a 851 853
disorder n/a 859 861
disorder n/a 863 865
disorder n/a 868 918

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P40189. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLTLQTWLVQ ALFIFLTTES TGELLDPCGY ISPESPVVQL HSNFTAVCVL
50
51
KEKCMDYFHV NANYIVWKTN HFTIPKEQYT IINRTASSVT FTDIASLNIQ
100
101
LTCNILTFGQ LEQNVYGITI ISGLPPEKPK NLSCIVNEGK KMRCEWDGGR
150
151
ETHLETNFTL KSEWATHKFA DCKAKRDTPT SCTVDYSTVY FVNIEVWVEA
200
201
ENALGKVTSD HINFDPVYKV KPNPPHNLSV INSEELSSIL KLTWTNPSIK
250
251
SVIILKYNIQ YRTKDASTWS QIPPEDTAST RSSFTVQDLK PFTEYVFRIR
300
301
CMKEDGKGYW SDWSEEASGI TYEDRPSKAP SFWYKIDPSH TQGYRTVQLV
350
351
WKTLPPFEAN GKILDYEVTL TRWKSHLQNY TVNATKLTVN LTNDRYLATL
400
401
TVRNLVGKSD AAVLTIPACD FQATHPVMDL KAFPKDNMLW VEWTTPRESV
450
451
KKYILEWCVL SDKAPCITDW QQEDGTVHRT YLRGNLAESK CYLITVTPVY
500
501
ADGPGSPESI KAYLKQAPPS KGPTVRTKKV GKNEAVLEWD QLPVDVQNGF
550
551
IRNYTIFYRT IIGNETAVNV DSSHTEYTLS SLTSDTLYMV RMAAYTDEGG
600
601
KDGPEFTFTT PKFAQGEIEA IVVPVCLAFL LTTLLGVLFC FNKRDLIKKH
650
651
IWPNVPDPSK SHIAQWSPHT PPRHNFNSKD QMYSDGNFTD VSVVEIEAND
700
701
KKPFPEDLKS LDLFKKEKIN TEGHSSGIGG SSCMSSSRPS ISSSDENESS
750
751
QNTSSTVQYS TVVHSGYRHQ VPSVQVFSRS ESTQPLLDSE ERPEDLQLVD
800
801
HVDGGDGILP RQQYFKQNCS QHESSPDISH FERSKQVSSV NEEDFVRLKQ
850
851
QISDHISQSC GSGQMKMFQE VSAADAFGPG TEGQVERFET VGMEAATDEG
900
901
MPKSYLPQTV RQGGYMPQ                                   
918
 

Show the unformatted sequence.

Checksums:
CRC64:6510A4409FFCF08C
MD5:fdfe55320e02af4874417e464d822185

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
fn3 223 - 311 1BJ8 A 7 - 95 Jmol OpenAstexViewer
1BQU A 105 - 193 Jmol OpenAstexViewer
B 105 - 193 Jmol OpenAstexViewer
1I1R A 201 - 289 Jmol OpenAstexViewer
1P9M A 201 - 289 Jmol OpenAstexViewer
1PVH A 201 - 289 Jmol OpenAstexViewer
C 201 - 289 Jmol OpenAstexViewer
3L5H A 201 - 289 Jmol OpenAstexViewer
518 - 605 3L5H A 496 - 583 Jmol OpenAstexViewer
3L5I A 496 - 583 Jmol OpenAstexViewer
3L5J A 496 - 583 Jmol OpenAstexViewer
B 496 - 583 Jmol OpenAstexViewer
IL6Ra-bind 131 - 218 1BQU A 13 - 100 Jmol OpenAstexViewer
B 13 - 100 Jmol OpenAstexViewer
1I1R A 109 - 196 Jmol OpenAstexViewer
1P9M A 109 - 196 Jmol OpenAstexViewer
1PVH A 109 - 196 Jmol OpenAstexViewer
C 109 - 196 Jmol OpenAstexViewer
3L5H A 109 - 196 Jmol OpenAstexViewer
Lep_receptor_Ig 26 - 111 3L5H A 4 - 89 Jmol OpenAstexViewer
26 - 112 1I1R A 4 - 90 Jmol OpenAstexViewer
1P9M A 4 - 90 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.