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7  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TCPZ_HUMAN (P40227)

Summary

This is the summary of UniProt entry TCPZ_HUMAN (P40227).

Description: T-complex protein 1 subunit zeta
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 531 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 10 20
Pfam Cpn60_TCP1 30 526
coiled_coil n/a 250 270
low_complexity n/a 406 420

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P40227. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAAVKTLNPK AEVARAQAAL AVNISAARGL QDVLRTNLGP KGTMKMLVSG
50
51
AGDIKLTKDG NVLLHEMQIQ HPTASLIAKV ATAQDDITGD GTTSNVLIIG
100
101
ELLKQADLYI SEGLHPRIIT EGFEAAKEKA LQFLEEVKVS REMDRETLID
150
151
VARTSLRTKV HAELADVLTE AVVDSILAIK KQDEPIDLFM IEIMEMKHKS
200
201
ETDTSLIRGL VLDHGARHPD MKKRVEDAYI LTCNVSLEYE KTEVNSGFFY
250
251
KSAEEREKLV KAERKFIEDR VKKIIELKRK VCGDSDKGFV VINQKGIDPF
300
301
SLDALSKEGI VALRRAKRRN MERLTLACGG VALNSFDDLS PDCLGHAGLV
350
351
YEYTLGEEKF TFIEKCNNPR SVTLLIKGPN KHTLTQIKDA VRDGLRAVKN
400
401
AIDDGCVVPG AGAVEVAMAE ALIKHKPSVK GRAQLGVQAF ADALLIIPKV
450
451
LAQNSGFDLQ ETLVKIQAEH SESGQLVGVD LNTGEPMVAA EVGVWDNYCV
500
501
KKQLLHSCTV IATNILLVDE IMRAGMSSLK G                    
531
 

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Checksums:
CRC64:43ABCF548CC82B81
MD5:2ab58a59dea1721a4bee676f2ee6968a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Cpn60_TCP1 30 - 522 6QB8 z 30 - 522 Jmol OpenAstexViewer
30 - 523 6NR8 N 30 - 523 Jmol OpenAstexViewer
6NR9 N 30 - 523 Jmol OpenAstexViewer
6NRA N 30 - 523 Jmol OpenAstexViewer
6NRB N 30 - 523 Jmol OpenAstexViewer
6NRC N 30 - 523 Jmol OpenAstexViewer
6NRD N 30 - 523 Jmol OpenAstexViewer
6QB8 Z 30 - 523 Jmol OpenAstexViewer
30 - 525 6NR8 F 30 - 525 Jmol OpenAstexViewer
6NR9 F 30 - 525 Jmol OpenAstexViewer
6NRA F 30 - 525 Jmol OpenAstexViewer
6NRB F 30 - 525 Jmol OpenAstexViewer
6NRC F 30 - 525 Jmol OpenAstexViewer
6NRD F 30 - 525 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.