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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CSK_HUMAN (P41240)

Summary

This is the summary of UniProt entry CSK_HUMAN (P41240).

Description: Tyrosine-protein kinase CSK
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 450 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam SH3_1 15 62
Pfam SH2 82 156
Pfam Pkinase_Tyr 195 440

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P41240. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA
50
51
KNKVGREGII PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE
100
101
TGLFLVREST NYPGDYTLCV SCDGKVEHYR IMYHASKLSI DEEVYFENLM
150
151
QLVEHYTSDA DGLCTRLIKP KVMEGTVAAQ DEFYRSGWAL NMKELKLLQT
200
201
IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM TQLRHSNLVQ
250
251
LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE
300
301
AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV
350
351
KWTAPEALRE KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE
400
401
KGYKMDAPDG CPPAVYEVMK NCWHLDAAMR PSFLQLREQL EHIKTHELHL
450
451
                                                      
450
 

Show the unformatted sequence.

Checksums:
CRC64:431023A88C54E00C
MD5:64016a73cb830d06c4225bede18f3ee5

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase_Tyr 195 - 440 1BYG A 195 - 440 Jmol OpenAstexViewer
3D7T A 195 - 440 Jmol OpenAstexViewer
3D7U A 195 - 440 Jmol OpenAstexViewer
C 195 - 440 Jmol OpenAstexViewer
SH2 82 - 156 3EAC A 82 - 156 Jmol OpenAstexViewer
3EAZ A 82 - 156 Jmol OpenAstexViewer
SH3_1 15 - 62 1CSK A 15 - 62 Jmol OpenAstexViewer
B 15 - 62 Jmol OpenAstexViewer
C 15 - 62 Jmol OpenAstexViewer
D 15 - 62 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.