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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PACR_HUMAN (P41586)

Summary

This is the summary of UniProt entry PACR_HUMAN (P41586).

Description: Pituitary adenylate cyclase-activating polypeptide type I receptor
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 468 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 23
low_complexity n/a 8 20
Pfam HRM 51 137
Pfam 7tm_2 150 396
transmembrane n/a 155 175
transmembrane n/a 187 205
transmembrane n/a 241 260
transmembrane n/a 267 287
transmembrane n/a 307 331
low_complexity n/a 318 331
transmembrane n/a 351 371
transmembrane n/a 383 403
low_complexity n/a 444 455

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P41586. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAGVVHVSLA ALLLLPMAPA MHSDCIFKKE QAMCLEKIQR ANELMGFNDS
50
51
SPGCPGMWDN ITCWKPAHVG EMVLVSCPEL FRIFNPDQVW ETETIGESDF
100
101
GDSNSLDLSD MGVVSRNCTE DGWSEPFPHY FDACGFDEYE SETGDQDYYY
150
151
LSVKALYTVG YSTSLVTLTT AMVILCRFRK LHCTRNFIHM NLFVSFMLRA
200
201
ISVFIKDWIL YAEQDSNHCF ISTVECKAVM VFFHYCVVSN YFWLFIEGLY
250
251
LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWATLRLY FDDTGCWDMN
300
301
DSTALWWVIK GPVVGSIMVN FVLFIGIIVI LVQKLQSPDM GGNESSIYLR
350
351
LARSTLLLIP LFGIHYTVFA FSPENVSKRE RLVFELGLGS FQGFVVAVLY
400
401
CFLNGEVQAE IKRKWRSWKV NRYFAVDFKH RHPSLASSGV NGGTQLSILS
450
451
KSSSQIRMSG LPADNLAT                                   
468
 

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Checksums:
CRC64:BB515B84E9F28977
MD5:00e62c1aa4dd3755158dfe49d21ffb04

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
HRM 51 - 137 2JOD A 51 - 116 Jmol OpenAstexViewer
3N94 A 51 - 116 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.