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9  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: KPCI_HUMAN (P41743)

Summary

This is the summary of UniProt entry KPCI_HUMAN (P41743).

Description: Protein kinase C iota type EC=2.7.11.13
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 596 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 19
Pfam PB1 25 107
Pfam C1_1 141 193
low_complexity n/a 173 185
disorder n/a 199 219
disorder n/a 221 225
disorder n/a 227 242
Pfam Pkinase 254 522
disorder n/a 455 458
disorder n/a 508 509
Pfam Pkinase_C 544 584
disorder n/a 558 560
disorder n/a 563 570

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P41743. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPTQRDSSTM SHTVAGGGSG DHSHQVRVKA YYRGDIMITH FEPSISFEGL
50
51
CNEVRDMCSF DNEQLFTMKW IDEEGDPCTV SSQLELEEAF RLYELNKDSE
100
101
LLIHVFPCVP ERPGMPCPGE DKSIYRRGAR RWRKLYCANG HTFQAKRFNR
150
151
RAHCAICTDR IWGLGRQGYK CINCKLLVHK KCHKLVTIEC GRHSLPQEPV
200
201
MPMDQSSMHS DHAQTVIPYN PSSHESLDQV GEEKEAMNTR ESGKASSSLG
250
251
LQDFDLLRVI GRGSYAKVLL VRLKKTDRIY AMKVVKKELV NDDEDIDWVQ
300
301
TEKHVFEQAS NHPFLVGLHS CFQTESRLFF VIEYVNGGDL MFHMQRQRKL
350
351
PEEHARFYSA EISLALNYLH ERGIIYRDLK LDNVLLDSEG HIKLTDYGMC
400
401
KEGLRPGDTT STFCGTPNYI APEILRGEDY GFSVDWWALG VLMFEMMAGR
450
451
SPFDIVGSSD NPDQNTEDYL FQVILEKQIR IPRSLSVKAA SVLKSFLNKD
500
501
PKERLGCHPQ TGFADIQGHP FFRNVDWDMM EQKQVVPPFK PNISGEFGLD
550
551
NFDSQFTNEP VQLTPDDDDI VRKIDQSEFE GFEYINPLLM SAEECV    
596
 

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Checksums:
CRC64:1E3F8C1D4BFC734F
MD5:955a0b1f912681537125328f43c515c6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
PB1 25 - 107 1VD2 A 16 - 98 Jmol OpenAstexViewer
1WMH A 16 - 98 Jmol OpenAstexViewer
Pkinase 254 - 522 1ZRZ A 245 - 513 Jmol OpenAstexViewer
3A8W A 245 - 513 Jmol OpenAstexViewer
B 245 - 513 Jmol OpenAstexViewer
3A8X A 245 - 513 Jmol OpenAstexViewer
B 245 - 513 Jmol OpenAstexViewer
3ZH8 A 245 - 513 Jmol OpenAstexViewer
B 245 - 513 Jmol OpenAstexViewer
C 245 - 513 Jmol OpenAstexViewer
5LI1 A 254 - 522 Jmol OpenAstexViewer
5LI9 A 254 - 522 Jmol OpenAstexViewer
5LIH A 254 - 522 Jmol OpenAstexViewer
B 254 - 522 Jmol OpenAstexViewer
Pkinase_C 544 - 584 3A8W A 535 - 575 Jmol OpenAstexViewer
B 535 - 575 Jmol OpenAstexViewer
3A8X A 535 - 575 Jmol OpenAstexViewer
B 535 - 575 Jmol OpenAstexViewer
3ZH8 A 535 - 575 Jmol OpenAstexViewer
B 535 - 575 Jmol OpenAstexViewer
5LI1 A 544 - 584 Jmol OpenAstexViewer
5LI9 A 544 - 584 Jmol OpenAstexViewer
5LIH A 544 - 584 Jmol OpenAstexViewer
B 544 - 584 Jmol OpenAstexViewer
561 - 584 1ZRZ A 552 - 575 Jmol OpenAstexViewer
562 - 584 3ZH8 C 553 - 575 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.