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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: STAT1_HUMAN (P42224)

Summary

This is the summary of UniProt entry STAT1_HUMAN (P42224).

Description: Signal transducer and activator of transcription 1-alpha/beta
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 750 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam STAT_int 2 120
disorder n/a 90 91
Pfam STAT_alpha 139 309
coiled_coil n/a 146 166
disorder n/a 183 190
coiled_coil n/a 266 290
low_complexity n/a 274 285
Pfam STAT_bind 321 458
disorder n/a 420 421
Pfam SH2 573 657
disorder n/a 615 616
disorder n/a 627 630
disorder n/a 679 698
Pfam STAT1_TAZ2bind 715 739
disorder n/a 717 726
disorder n/a 728 729

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P42224. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSQWYELQQL DSKFLEQVHQ LYDDSFPMEI RQYLAQWLEK QDWEHAANDV
50
51
SFATIRFHDL LSQLDDQYSR FSLENNFLLQ HNIRKSKRNL QDNFQEDPIQ
100
101
MSMIIYSCLK EERKILENAQ RFNQAQSGNI QSTVMLDKQK ELDSKVRNVK
150
151
DKVMCIEHEI KSLEDLQDEY DFKCKTLQNR EHETNGVAKS DQKQEQLLLK
200
201
KMYLMLDNKR KEVVHKIIEL LNVTELTQNA LINDELVEWK RRQQSACIGG
250
251
PPNACLDQLQ NWFTIVAESL QQVRQQLKKL EELEQKYTYE HDPITKNKQV
300
301
LWDRTFSLFQ QLIQSSFVVE RQPCMPTHPQ RPLVLKTGVQ FTVKLRLLVK
350
351
LQELNYNLKV KVLFDKDVNE RNTVKGFRKF NILGTHTKVM NMEESTNGSL
400
401
AAEFRHLQLK EQKNAGTRTN EGPLIVTEEL HSLSFETQLC QPGLVIDLET
450
451
TSLPVVVISN VSQLPSGWAS ILWYNMLVAE PRNLSFFLTP PCARWAQLSE
500
501
VLSWQFSSVT KRGLNVDQLN MLGEKLLGPN ASPDGLIPWT RFCKENINDK
550
551
NFPFWLWIES ILELIKKHLL PLWNDGCIMG FISKERERAL LKDQQPGTFL
600
601
LRFSESSREG AITFTWVERS QNGGEPDFHA VEPYTKKELS AVTFPDIIRN
650
651
YKVMAAENIP ENPLKYLYPN IDKDHAFGKY YSRPKEAPEP MELDGPKGTG
700
701
YIKTELISVS EVHPSRLQTT DNLLPMSPEE FDEVSRIVGS VEFDSMMNTV
750
751
                                                      
750
 

Show the unformatted sequence.

Checksums:
CRC64:054A813522364BA6
MD5:928d3192950db622b5cc70171385c78d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SH2 573 - 657 1BF5 A 573 - 657 Jmol OpenAstexViewer
1YVL A 573 - 657 Jmol OpenAstexViewer
B 1573 - 1657 Jmol OpenAstexViewer
STAT1_TAZ2bind 715 - 739 2KA6 B 715 - 739 Jmol OpenAstexViewer
STAT_alpha 139 - 309 1BF5 A 139 - 309 Jmol OpenAstexViewer
1YVL A 139 - 309 Jmol OpenAstexViewer
B 1139 - 1309 Jmol OpenAstexViewer
STAT_bind 321 - 458 1BF5 A 321 - 458 Jmol OpenAstexViewer
1YVL A 321 - 458 Jmol OpenAstexViewer
B 1321 - 1458 Jmol OpenAstexViewer
STAT_int 2 - 120 1YVL A 2 - 120 Jmol OpenAstexViewer
B 1002 - 1120 Jmol OpenAstexViewer
3WWT A 2 - 120 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.