Summary
This is the summary of UniProt entry STAT1_HUMAN (P42224).
| Description: | Signal transducer and activator of transcription 1-alpha/beta |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 750 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
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| Source | Domain | Start | End |
|---|---|---|---|
| Pfam | STAT_int | 2 | 120 |
| disorder | n/a | 90 | 91 |
| Pfam | STAT_alpha | 139 | 309 |
| coiled_coil | n/a | 146 | 166 |
| disorder | n/a | 183 | 190 |
| coiled_coil | n/a | 266 | 290 |
| low_complexity | n/a | 274 | 285 |
| Pfam | STAT_bind | 321 | 458 |
| disorder | n/a | 420 | 421 |
| Pfam | SH2 | 573 | 657 |
| disorder | n/a | 615 | 616 |
| disorder | n/a | 627 | 630 |
| disorder | n/a | 679 | 698 |
| Pfam | STAT1_TAZ2bind | 715 | 739 |
| disorder | n/a | 717 | 726 |
| disorder | n/a | 728 | 729 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P42224. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MSQWYELQQL DSKFLEQVHQ LYDDSFPMEI RQYLAQWLEK QDWEHAANDV
50 51
SFATIRFHDL LSQLDDQYSR FSLENNFLLQ HNIRKSKRNL QDNFQEDPIQ
100 101
MSMIIYSCLK EERKILENAQ RFNQAQSGNI QSTVMLDKQK ELDSKVRNVK
150 151
DKVMCIEHEI KSLEDLQDEY DFKCKTLQNR EHETNGVAKS DQKQEQLLLK
200 201
KMYLMLDNKR KEVVHKIIEL LNVTELTQNA LINDELVEWK RRQQSACIGG
250 251
PPNACLDQLQ NWFTIVAESL QQVRQQLKKL EELEQKYTYE HDPITKNKQV
300 301
LWDRTFSLFQ QLIQSSFVVE RQPCMPTHPQ RPLVLKTGVQ FTVKLRLLVK
350 351
LQELNYNLKV KVLFDKDVNE RNTVKGFRKF NILGTHTKVM NMEESTNGSL
400 401
AAEFRHLQLK EQKNAGTRTN EGPLIVTEEL HSLSFETQLC QPGLVIDLET
450 451
TSLPVVVISN VSQLPSGWAS ILWYNMLVAE PRNLSFFLTP PCARWAQLSE
500 501
VLSWQFSSVT KRGLNVDQLN MLGEKLLGPN ASPDGLIPWT RFCKENINDK
550 551
NFPFWLWIES ILELIKKHLL PLWNDGCIMG FISKERERAL LKDQQPGTFL
600 601
LRFSESSREG AITFTWVERS QNGGEPDFHA VEPYTKKELS AVTFPDIIRN
650 651
YKVMAAENIP ENPLKYLYPN IDKDHAFGKY YSRPKEAPEP MELDGPKGTG
700 701
YIKTELISVS EVHPSRLQTT DNLLPMSPEE FDEVSRIVGS VEFDSMMNTV
750 751
750
Show the unformatted sequence. |
| Checksums: |
CRC64:054A813522364BA6
MD5:928d3192950db622b5cc70171385c78d
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| SH2 | 573 - 657 | 1BF5 | A | 573 - 657 | Jmol OpenAstexViewer |
| 1YVL | A | 573 - 657 | Jmol OpenAstexViewer | ||
| B | 1573 - 1657 | Jmol OpenAstexViewer | |||
| STAT1_TAZ2bind | 715 - 739 | 2KA6 | B | 715 - 739 | Jmol OpenAstexViewer |
| STAT_alpha | 139 - 309 | 1BF5 | A | 139 - 309 | Jmol OpenAstexViewer |
| 1YVL | A | 139 - 309 | Jmol OpenAstexViewer | ||
| B | 1139 - 1309 | Jmol OpenAstexViewer | |||
| STAT_bind | 321 - 458 | 1BF5 | A | 321 - 458 | Jmol OpenAstexViewer |
| 1YVL | A | 321 - 458 | Jmol OpenAstexViewer | ||
| B | 1321 - 1458 | Jmol OpenAstexViewer | |||
| STAT_int | 2 - 120 | 1YVL | A | 2 - 120 | Jmol OpenAstexViewer |
| B | 1002 - 1120 | Jmol OpenAstexViewer | |||
| 3WWT | A | 2 - 120 | Jmol OpenAstexViewer |
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
