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10  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: GRIA2_HUMAN (P42262)

Summary

This is the summary of UniProt entry GRIA2_HUMAN (P42262).

Description: Glutamate receptor 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 883 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 24
Pfam ANF_receptor 44 382
Pfam Lig_chan-Glu_bd 414 529
transmembrane n/a 542 564
Pfam Lig_chan 543 824
low_complexity n/a 556 567
disorder n/a 578 583
transmembrane n/a 625 647
transmembrane n/a 815 837
low_complexity n/a 819 831
disorder n/a 851 854
low_complexity n/a 852 864

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P42262. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MQKIMHISVL LSPVLWGLIF GVSSNSIQIG GLFPRGADQE YSAFRVGMVQ
50
51
FSTSEFRLTP HIDNLEVANS FAVTNAFCSQ FSRGVYAIFG FYDKKSVNTI
100
101
TSFCGTLHVS FITPSFPTDG THPFVIQMRP DLKGALLSLI EYYQWDKFAY
150
151
LYDSDRGLST LQAVLDSAAE KKWQVTAINV GNINNDKKDE MYRSLFQDLE
200
201
LKKERRVILD CERDKVNDIV DQVITIGKHV KGYHYIIANL GFTDGDLLKI
250
251
QFGGANVSGF QIVDYDDSLV SKFIERWSTL EEKEYPGAHT TTIKYTSALT
300
301
YDAVQVMTEA FRNLRKQRIE ISRRGNAGDC LANPAVPWGQ GVEIERALKQ
350
351
VQVEGLSGNI KFDQNGKRIN YTINIMELKT NGPRKIGYWS EVDKMVVTLT
400
401
ELPSGNDTSG LENKTVVVTT ILESPYVMMK KNHEMLEGNE RYEGYCVDLA
450
451
AEIAKHCGFK YKLTIVGDGK YGARDADTKI WNGMVGELVY GKADIAIAPL
500
501
TITLVREEVI DFSKPFMSLG ISIMIKKPQK SKPGVFSFLD PLAYEIWMCI
550
551
VFAYIGVSVV LFLVSRFSPY EWHTEEFEDG RETQSSESTN EFGIFNSLWF
600
601
SLGAFMQQGC DISPRSLSGR IVGGVWWFFT LIIISSYTAN LAAFLTVERM
650
651
VSPIESAEDL SKQTEIAYGT LDSGSTKEFF RRSKIAVFDK MWTYMRSAEP
700
701
SVFVRTTAEG VARVRKSKGK YAYLLESTMN EYIEQRKPCD TMKVGGNLDS
750
751
KGYGIATPKG SSLRNAVNLA VLKLNEQGLL DKLKNKWWYD KGECGSGGGD
800
801
SKEKTSALSL SNVAGVFYIL VGGLGLAMLV ALIEFCYKSR AEAKRMKVAK
850
851
NAQNINPSSS QNSQNFATYK EGYNVYGIES VKI                  
883
 

Show the unformatted sequence.

Checksums:
CRC64:6DAB96C76D1D8448
MD5:eefe3d9635a4130e00044c5dcbc19a79

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ANF_receptor 44 - 382 2WJW A 44 - 382 Jmol OpenAstexViewer
2WJX A 44 - 382 Jmol OpenAstexViewer
B 44 - 382 Jmol OpenAstexViewer
C 44 - 382 Jmol OpenAstexViewer
Lig_chan 603 - 795 2XHD B 118 - 262 Jmol OpenAstexViewer
603 - 796 2XHD A 118 - 263 Jmol OpenAstexViewer
653 - 794 3R7X A 120 - 261 Jmol OpenAstexViewer
B 120 - 261 Jmol OpenAstexViewer
3RN8 A 120 - 261 Jmol OpenAstexViewer
B 120 - 261 Jmol OpenAstexViewer
C 120 - 261 Jmol OpenAstexViewer
3RNN A 120 - 261 Jmol OpenAstexViewer
B 120 - 261 Jmol OpenAstexViewer
C 120 - 261 Jmol OpenAstexViewer
3UA8 A 120 - 261 Jmol OpenAstexViewer
5H8S A 120 - 261 Jmol OpenAstexViewer
B 120 - 261 Jmol OpenAstexViewer
5YBG C 653 - 794 Jmol OpenAstexViewer
653 - 795 5H8S C 120 - 262 Jmol OpenAstexViewer
5YBF A 653 - 795 Jmol OpenAstexViewer
B 653 - 795 Jmol OpenAstexViewer
C 653 - 795 Jmol OpenAstexViewer
D 653 - 795 Jmol OpenAstexViewer
E 653 - 795 Jmol OpenAstexViewer
F 653 - 795 Jmol OpenAstexViewer
5YBG A 653 - 795 Jmol OpenAstexViewer
B 653 - 795 Jmol OpenAstexViewer
D 653 - 795 Jmol OpenAstexViewer
F 653 - 795 Jmol OpenAstexViewer
653 - 796 5YBG E 653 - 796 Jmol OpenAstexViewer
Lig_chan-Glu_bd 414 - 527 2XHD A 4 - 117 Jmol OpenAstexViewer
B 4 - 117 Jmol OpenAstexViewer
3R7X A 4 - 117 Jmol OpenAstexViewer
3RN8 A 4 - 117 Jmol OpenAstexViewer
B 4 - 117 Jmol OpenAstexViewer
C 4 - 117 Jmol OpenAstexViewer
3RNN A 4 - 117 Jmol OpenAstexViewer
B 4 - 117 Jmol OpenAstexViewer
C 4 - 117 Jmol OpenAstexViewer
5H8S A 4 - 117 Jmol OpenAstexViewer
B 4 - 117 Jmol OpenAstexViewer
C 4 - 117 Jmol OpenAstexViewer
5YBF A 414 - 527 Jmol OpenAstexViewer
B 414 - 527 Jmol OpenAstexViewer
C 414 - 527 Jmol OpenAstexViewer
D 414 - 527 Jmol OpenAstexViewer
E 414 - 527 Jmol OpenAstexViewer
F 414 - 527 Jmol OpenAstexViewer
5YBG A 414 - 527 Jmol OpenAstexViewer
B 414 - 527 Jmol OpenAstexViewer
C 414 - 527 Jmol OpenAstexViewer
D 414 - 527 Jmol OpenAstexViewer
E 414 - 527 Jmol OpenAstexViewer
F 414 - 527 Jmol OpenAstexViewer
415 - 527 3R7X B 5 - 117 Jmol OpenAstexViewer
3UA8 A 5 - 117 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.