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14  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AF9_HUMAN (P42568)

Summary

This is the summary of UniProt entry AF9_HUMAN (P42568).

Description: Protein AF-9 {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 568 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam YEATS 27 108
disorder n/a 116 123
disorder n/a 130 308
low_complexity n/a 149 190
low_complexity n/a 226 246
low_complexity n/a 254 265
low_complexity n/a 290 306
low_complexity n/a 299 313
disorder n/a 318 498
low_complexity n/a 341 351
low_complexity n/a 371 395
low_complexity n/a 412 430
low_complexity n/a 437 453
low_complexity n/a 446 471
Pfam AHD 503 563

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P42568. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASSCAVQVK LELGHRAQVR KKPTVEGFTH DWMVFVRGPE HSNIQHFVEK
50
51
VVFHLHESFP RPKRVCKDPP YKVEESGYAG FILPIEVYFK NKEEPRKVRF
100
101
DYDLFLHLEG HPPVNHLRCE KLTFNNPTED FRRKLLKAGG DPNRSIHTSS
150
151
SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS TSFSKPHKLM
200
201
KEHKEKPSKD SREHKSAFKE PSRDHNKSSK ESSKKPKENK PLKEEKIVPK
250
251
MAFKEPKPMS KEPKPDSNLL TITSGQDKKA PSKRPPISDS EELSAKKRKK
300
301
SSSEALFKSF SSAPPLILTC SADKKQIKDK SHVKMGKVKI ESETSEKKKS
350
351
TLPPFDDIVD PNDSDVEENI SSKSDSEQPS PASSSSSSSS SFTPSQTRQQ
400
401
GPLRSIMKDL HSDDNEEESD EVEDNDNDSE MERPVNRGGS RSRRVSLSDG
450
451
SDSESSSASS PLHHEPPPPL LKTNNNQILE VKSPIKQSKS DKQIKNGECD
500
501
KAYLDELVEL HRRLMTLRER HILQQIVNLI EETGHFHITN TTFDFDLCSL
550
551
DKTTVRKLQS YLETSGTS                                   
568
 

Show the unformatted sequence.

Checksums:
CRC64:0A020B7FB34132F9
MD5:ba05abf472c72920b0d36db229b3d33b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
AHD 503 - 563 2LM0 A 1503 - 1563 Show 3D Structure View in InterPro
2MV7 A 503 - 563 Show 3D Structure View in InterPro
2N4Q B 503 - 563 Show 3D Structure View in InterPro
6B7G A 503 - 563 Show 3D Structure View in InterPro
YEATS 27 - 108 2NDF A 30 - 111 Show 3D Structure View in InterPro
2NDG A 30 - 111 Show 3D Structure View in InterPro
4TMP A 27 - 108 Show 3D Structure View in InterPro
C 27 - 108 Show 3D Structure View in InterPro
5HJB A 27 - 108 Show 3D Structure View in InterPro
5HJD A 27 - 108 Show 3D Structure View in InterPro
C 27 - 108 Show 3D Structure View in InterPro
E 27 - 108 Show 3D Structure View in InterPro
G 27 - 108 Show 3D Structure View in InterPro
K 27 - 108 Show 3D Structure View in InterPro
N 27 - 108 Show 3D Structure View in InterPro
Q 27 - 108 Show 3D Structure View in InterPro
T 27 - 108 Show 3D Structure View in InterPro
5YYF A 27 - 108 Show 3D Structure View in InterPro
C 27 - 108 Show 3D Structure View in InterPro
6L5Z A 27 - 108 Show 3D Structure View in InterPro
6LS6 A 30 - 111 Show 3D Structure View in InterPro
B 30 - 111 Show 3D Structure View in InterPro
6MIL A 27 - 108 Show 3D Structure View in InterPro
C 27 - 108 Show 3D Structure View in InterPro
6MIM A 27 - 108 Show 3D Structure View in InterPro
C 27 - 108 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;