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116  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CASP3_HUMAN (P42574)

Summary

This is the summary of UniProt entry CASP3_HUMAN (P42574).

Description: Caspase-3 EC=3.4.22.56
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 277 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 19
disorder n/a 24 25
Pfam Peptidase_C14 44 274
disorder n/a 59 69
disorder n/a 96 97

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P42574. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MENTENSVDS KSIKNLEPKI IHGSESMDSG ISLDNSYKMD YPEMGLCIII
50
51
NNKNFHKSTG MTSRSGTDVD AANLRETFRN LKYEVRNKND LTREEIVELM
100
101
RDVSKEDHSK RSSFVCVLLS HGEEGIIFGT NGPVDLKKIT NFFRGDRCRS
150
151
LTGKPKLFII QACRGTELDC GIETDSGVDD DMACHKIPVE ADFLYAYSTA
200
201
PGYYSWRNSK DGSWFIQSLC AMLKQYADKL EFMHILTRVN RKVATEFESF
250
251
SFDATFHAKK QIPCIVSMLT KELYFYH                         
277
 

Show the unformatted sequence.

Checksums:
CRC64:2F35CD3BCF7FF64A
MD5:cd9050995bb3aa9f42ca5d1eedd10b2d

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Peptidase_C14 176 - 274 1I3O B 310 - 399 Show 3D Structure View in InterPro
D 310 - 399 Show 3D Structure View in InterPro
2C1E B 176 - 274 Show 3D Structure View in InterPro
2C2K B 176 - 274 Show 3D Structure View in InterPro
2C2M B 176 - 274 Show 3D Structure View in InterPro
2C2O B 176 - 274 Show 3D Structure View in InterPro
2CDR B 176 - 274 Show 3D Structure View in InterPro
2CJY B 176 - 274 Show 3D Structure View in InterPro
2CNK B 176 - 274 Show 3D Structure View in InterPro
2CNL B 176 - 274 Show 3D Structure View in InterPro
2CNN B 176 - 274 Show 3D Structure View in InterPro
2DKO B 176 - 274 Show 3D Structure View in InterPro
3KJF B 176 - 274 Show 3D Structure View in InterPro
6CL0 B 176 - 274 Show 3D Structure View in InterPro
178 - 274 6BGS C 178 - 274 Show 3D Structure View in InterPro
179 - 274 6BHA B 179 - 274 Show 3D Structure View in InterPro
184 - 274 2H5J B 184 - 274 Show 3D Structure View in InterPro
2XZD B 184 - 274 Show 3D Structure View in InterPro
2XZT B 184 - 274 Show 3D Structure View in InterPro
2Y0B B 184 - 274 Show 3D Structure View in InterPro
3GJS B 184 - 274 Show 3D Structure View in InterPro
6BFJ B 184 - 274 Show 3D Structure View in InterPro
185 - 274 1GFW B 185 - 274 Show 3D Structure View in InterPro
2CNO B 185 - 274 Show 3D Structure View in InterPro
2H5I B 185 - 274 Show 3D Structure View in InterPro
2H5J D 185 - 274 Show 3D Structure View in InterPro
2XYG B 185 - 274 Show 3D Structure View in InterPro
2XYH B 185 - 274 Show 3D Structure View in InterPro
2XYP B 185 - 274 Show 3D Structure View in InterPro
2XZD D 185 - 274 Show 3D Structure View in InterPro
2XZT D 185 - 274 Show 3D Structure View in InterPro
2Y0B D 185 - 274 Show 3D Structure View in InterPro
3GJQ B 185 - 274 Show 3D Structure View in InterPro
D 185 - 274 Show 3D Structure View in InterPro
3GJT D 185 - 274 Show 3D Structure View in InterPro
4DCJ B 185 - 274 Show 3D Structure View in InterPro
E 1185 - 1274 Show 3D Structure View in InterPro
4DCO B 185 - 274 Show 3D Structure View in InterPro
E 1185 - 1274 Show 3D Structure View in InterPro
4DCP B 185 - 274 Show 3D Structure View in InterPro
E 1185 - 1274 Show 3D Structure View in InterPro
5IC4 B 185 - 274 Show 3D Structure View in InterPro
H 185 - 274 Show 3D Structure View in InterPro
6BDV B 185 - 274 Show 3D Structure View in InterPro
6BFK C 185 - 274 Show 3D Structure View in InterPro
6BFL B 185 - 274 Show 3D Structure View in InterPro
6BFO B 185 - 274 Show 3D Structure View in InterPro
6BG0 C 185 - 274 Show 3D Structure View in InterPro
D 185 - 274 Show 3D Structure View in InterPro
6BG1 C 185 - 274 Show 3D Structure View in InterPro
6BG4 E 185 - 274 Show 3D Structure View in InterPro
F 185 - 274 Show 3D Structure View in InterPro
6BGK C 185 - 274 Show 3D Structure View in InterPro
D 185 - 274 Show 3D Structure View in InterPro
6BGQ B 185 - 274 Show 3D Structure View in InterPro
D 185 - 274 Show 3D Structure View in InterPro
6BGR B 185 - 274 Show 3D Structure View in InterPro
6BH9 C 185 - 274 Show 3D Structure View in InterPro
E 185 - 274 Show 3D Structure View in InterPro
6CKZ B 185 - 274 Show 3D Structure View in InterPro
186 - 274 1NME B 186 - 274 Show 3D Structure View in InterPro
1PAU B 320 - 399 Show 3D Structure View in InterPro
1RE1 B 320 - 399 Show 3D Structure View in InterPro
1RHJ B 320 - 399 Show 3D Structure View in InterPro
D 820 - 899 Show 3D Structure View in InterPro
1RHK B 320 - 399 Show 3D Structure View in InterPro
1RHM B 320 - 399 Show 3D Structure View in InterPro
D 820 - 899 Show 3D Structure View in InterPro
1RHQ B 320 - 399 Show 3D Structure View in InterPro
E 320 - 399 Show 3D Structure View in InterPro
1RHR B 320 - 399 Show 3D Structure View in InterPro
1RHU B 320 - 399 Show 3D Structure View in InterPro
2CJX B 186 - 274 Show 3D Structure View in InterPro
2H65 B 186 - 274 Show 3D Structure View in InterPro
D 186 - 274 Show 3D Structure View in InterPro
3EDQ B 186 - 274 Show 3D Structure View in InterPro
D 186 - 274 Show 3D Structure View in InterPro
3GJR B 186 - 274 Show 3D Structure View in InterPro
D 186 - 274 Show 3D Structure View in InterPro
3GJS D 186 - 274 Show 3D Structure View in InterPro
3GJT B 186 - 274 Show 3D Structure View in InterPro
5IC4 D 186 - 274 Show 3D Structure View in InterPro
F 186 - 274 Show 3D Structure View in InterPro
6BFK D 186 - 274 Show 3D Structure View in InterPro
44 - 171 6BFK A 44 - 171 Show 3D Structure View in InterPro
B 44 - 171 Show 3D Structure View in InterPro
44 - 173 1GFW A 44 - 173 Show 3D Structure View in InterPro
1PAU A 162 - 295 Show 3D Structure View in InterPro
1RE1 A 162 - 295 Show 3D Structure View in InterPro
1RHJ A 162 - 295 Show 3D Structure View in InterPro
C 662 - 795 Show 3D Structure View in InterPro
1RHK A 162 - 295 Show 3D Structure View in InterPro
1RHM A 162 - 295 Show 3D Structure View in InterPro
C 662 - 795 Show 3D Structure View in InterPro
1RHQ A 162 - 295 Show 3D Structure View in InterPro
D 162 - 295 Show 3D Structure View in InterPro
1RHR A 162 - 295 Show 3D Structure View in InterPro
1RHU A 162 - 295 Show 3D Structure View in InterPro
3KJF A 44 - 173 Show 3D Structure View in InterPro
5IC4 A 44 - 173 Show 3D Structure View in InterPro
C 44 - 173 Show 3D Structure View in InterPro
E 44 - 173 Show 3D Structure View in InterPro
6BFO A 44 - 173 Show 3D Structure View in InterPro
44 - 174 1I3O A 162 - 296 Show 3D Structure View in InterPro
1NME A 44 - 174 Show 3D Structure View in InterPro
2CNK A 44 - 174 Show 3D Structure View in InterPro
2DKO A 44 - 174 Show 3D Structure View in InterPro
2H5I A 44 - 174 Show 3D Structure View in InterPro
2H5J A 44 - 174 Show 3D Structure View in InterPro
C 44 - 174 Show 3D Structure View in InterPro
2H65 A 44 - 174 Show 3D Structure View in InterPro
C 44 - 174 Show 3D Structure View in InterPro
2XYG A 44 - 174 Show 3D Structure View in InterPro
2XYH A 44 - 174 Show 3D Structure View in InterPro
2XYP A 44 - 174 Show 3D Structure View in InterPro
2XZD A 44 - 174 Show 3D Structure View in InterPro
2XZT A 44 - 174 Show 3D Structure View in InterPro
2Y0B A 44 - 174 Show 3D Structure View in InterPro
C 44 - 174 Show 3D Structure View in InterPro
3EDQ A 44 - 174 Show 3D Structure View in InterPro
C 44 - 174 Show 3D Structure View in InterPro
3GJQ A 44 - 174 Show 3D Structure View in InterPro
C 44 - 174 Show 3D Structure View in InterPro
3GJR A 44 - 174 Show 3D Structure View in InterPro
C 44 - 174 Show 3D Structure View in InterPro
3GJS A 44 - 174 Show 3D Structure View in InterPro
C 44 - 174 Show 3D Structure View in InterPro
3GJT A 44 - 174 Show 3D Structure View in InterPro
C 44 - 174 Show 3D Structure View in InterPro
4DCJ A 44 - 174 Show 3D Structure View in InterPro
D 1044 - 1174 Show 3D Structure View in InterPro
4DCO A 44 - 174 Show 3D Structure View in InterPro
D 1044 - 1174 Show 3D Structure View in InterPro
4DCP A 44 - 174 Show 3D Structure View in InterPro
D 1044 - 1174 Show 3D Structure View in InterPro
5IC4 G 44 - 174 Show 3D Structure View in InterPro
6BDV A 44 - 174 Show 3D Structure View in InterPro
6BFJ A 44 - 174 Show 3D Structure View in InterPro
6BFL A 44 - 174 Show 3D Structure View in InterPro
6BG0 A 44 - 174 Show 3D Structure View in InterPro
B 44 - 174 Show 3D Structure View in InterPro
6BG1 A 44 - 174 Show 3D Structure View in InterPro
6BG4 A 44 - 174 Show 3D Structure View in InterPro
B 44 - 174 Show 3D Structure View in InterPro
6BGK A 44 - 174 Show 3D Structure View in InterPro
B 44 - 174 Show 3D Structure View in InterPro
6BGQ A 44 - 174 Show 3D Structure View in InterPro
C 44 - 174 Show 3D Structure View in InterPro
6BGR A 44 - 174 Show 3D Structure View in InterPro
6BGS A 44 - 174 Show 3D Structure View in InterPro
6BH9 A 44 - 174 Show 3D Structure View in InterPro
B 44 - 174 Show 3D Structure View in InterPro
6BHA A 44 - 174 Show 3D Structure View in InterPro
6CKZ A 44 - 174 Show 3D Structure View in InterPro
6CL0 A 44 - 174 Show 3D Structure View in InterPro
44 - 175 1I3O C 162 - 297 Show 3D Structure View in InterPro
2C1E A 44 - 175 Show 3D Structure View in InterPro
2C2K A 44 - 175 Show 3D Structure View in InterPro
2C2M A 44 - 175 Show 3D Structure View in InterPro
2C2O A 44 - 175 Show 3D Structure View in InterPro
2CDR A 44 - 175 Show 3D Structure View in InterPro
2CJX A 44 - 175 Show 3D Structure View in InterPro
2CJY A 44 - 175 Show 3D Structure View in InterPro
2CNL A 44 - 175 Show 3D Structure View in InterPro
2CNN A 44 - 175 Show 3D Structure View in InterPro
2CNO A 44 - 175 Show 3D Structure View in InterPro
2XZD C 44 - 175 Show 3D Structure View in InterPro
2XZT C 44 - 175 Show 3D Structure View in InterPro
44 - 274 1CP3 A 44 - 274 Show 3D Structure View in InterPro
B 44 - 274 Show 3D Structure View in InterPro
1NMQ A 44 - 274 Show 3D Structure View in InterPro
B 44 - 274 Show 3D Structure View in InterPro
1NMS A 44 - 274 Show 3D Structure View in InterPro
B 44 - 274 Show 3D Structure View in InterPro
1QX3 A 44 - 274 Show 3D Structure View in InterPro
2J30 A 44 - 274 Show 3D Structure View in InterPro
2J31 A 44 - 274 Show 3D Structure View in InterPro
2J32 A 44 - 274 Show 3D Structure View in InterPro
2J33 A 44 - 274 Show 3D Structure View in InterPro
3DEH A 44 - 274 Show 3D Structure View in InterPro
B 44 - 274 Show 3D Structure View in InterPro
C 44 - 274 Show 3D Structure View in InterPro
D 44 - 274 Show 3D Structure View in InterPro
3DEI A 44 - 274 Show 3D Structure View in InterPro
B 44 - 274 Show 3D Structure View in InterPro
C 44 - 274 Show 3D Structure View in InterPro
D 44 - 274 Show 3D Structure View in InterPro
3DEJ A 44 - 274 Show 3D Structure View in InterPro
B 44 - 274 Show 3D Structure View in InterPro
C 44 - 274 Show 3D Structure View in InterPro
D 44 - 274 Show 3D Structure View in InterPro
3DEK A 44 - 274 Show 3D Structure View in InterPro
B 44 - 274 Show 3D Structure View in InterPro
C 44 - 274 Show 3D Structure View in InterPro
D 44 - 274 Show 3D Structure View in InterPro
3H0E A 44 - 274 Show 3D Structure View in InterPro
B 44 - 274 Show 3D Structure View in InterPro
3ITN A 44 - 274 Show 3D Structure View in InterPro
3PCX A 44 - 274 Show 3D Structure View in InterPro
3PD0 A 44 - 274 Show 3D Structure View in InterPro
3PD1 A 44 - 274 Show 3D Structure View in InterPro
4EHA A 44 - 274 Show 3D Structure View in InterPro
C 44 - 274 Show 3D Structure View in InterPro
4EHD A 44 - 274 Show 3D Structure View in InterPro
4EHF A 44 - 274 Show 3D Structure View in InterPro
4EHH A 44 - 274 Show 3D Structure View in InterPro
4EHK A 44 - 274 Show 3D Structure View in InterPro
C 44 - 274 Show 3D Structure View in InterPro
4EHL A 44 - 274 Show 3D Structure View in InterPro
C 44 - 274 Show 3D Structure View in InterPro
4EHN A 44 - 274 Show 3D Structure View in InterPro
4JJE A 44 - 274 Show 3D Structure View in InterPro
4JQY A 44 - 274 Show 3D Structure View in InterPro
B 44 - 274 Show 3D Structure View in InterPro
4JQZ A 44 - 274 Show 3D Structure View in InterPro
B 44 - 274 Show 3D Structure View in InterPro
4JR0 A 44 - 274 Show 3D Structure View in InterPro
B 44 - 274 Show 3D Structure View in InterPro
4PRY A 44 - 274 Show 3D Structure View in InterPro
4PS0 A 44 - 274 Show 3D Structure View in InterPro
B 44 - 274 Show 3D Structure View in InterPro
4QTX A 44 - 274 Show 3D Structure View in InterPro
4QTY A 44 - 274 Show 3D Structure View in InterPro
4QU0 A 44 - 274 Show 3D Structure View in InterPro
4QU5 A 44 - 274 Show 3D Structure View in InterPro
4QU8 A 44 - 274 Show 3D Structure View in InterPro
4QU9 A 44 - 274 Show 3D Structure View in InterPro
4QUA A 44 - 274 Show 3D Structure View in InterPro
4QUB A 44 - 274 Show 3D Structure View in InterPro
4QUD A 44 - 274 Show 3D Structure View in InterPro
B 44 - 274 Show 3D Structure View in InterPro
4QUE A 44 - 274 Show 3D Structure View in InterPro
C 44 - 274 Show 3D Structure View in InterPro
4QUG A 44 - 274 Show 3D Structure View in InterPro
C 44 - 274 Show 3D Structure View in InterPro
4QUH A 44 - 274 Show 3D Structure View in InterPro
C 44 - 274 Show 3D Structure View in InterPro
4QUI A 44 - 274 Show 3D Structure View in InterPro
B 44 - 274 Show 3D Structure View in InterPro
4QUJ A 44 - 274 Show 3D Structure View in InterPro
4QUL A 44 - 274 Show 3D Structure View in InterPro
C 44 - 274 Show 3D Structure View in InterPro
5I9B A 44 - 274 Show 3D Structure View in InterPro
5I9T A 44 - 274 Show 3D Structure View in InterPro
C 44 - 274 Show 3D Structure View in InterPro
5IAB A 44 - 274 Show 3D Structure View in InterPro
C 44 - 274 Show 3D Structure View in InterPro
5IAE A 44 - 274 Show 3D Structure View in InterPro
C 44 - 274 Show 3D Structure View in InterPro
5IAG A 44 - 274 Show 3D Structure View in InterPro
5IAJ A 44 - 274 Show 3D Structure View in InterPro
5IAK A 44 - 274 Show 3D Structure View in InterPro
5IAN A 44 - 274 Show 3D Structure View in InterPro
5IAR A 44 - 274 Show 3D Structure View in InterPro
5IAS A 44 - 274 Show 3D Structure View in InterPro
5IBC A 44 - 274 Show 3D Structure View in InterPro
5IBP A 44 - 274 Show 3D Structure View in InterPro
5IBR A 44 - 274 Show 3D Structure View in InterPro
C 44 - 274 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;