Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: FADH_ECOLI (P42593)

Summary

This is the summary of UniProt entry FADH_ECOLI (P42593).

Description: 2,4-dienoyl-CoA reductase [NADPH] EC=1.3.1.34
Source organism: Escherichia coli (strain K12) (NCBI taxonomy ID 83333)
View Pfam proteome data.
Length: 672 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam Oxidored_FMN 5 331
disorder n/a 84 87
low_complexity n/a 190 205
Pfam Pyr_redox_2 375 656
low_complexity n/a 376 389
disorder n/a 543 547
disorder n/a 555 560
disorder n/a 562 565

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P42593. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSYPSLFAPL DLGFTTLKNR VLMGSMHTGL EEYPDGAERL AAFYAERARH
50
51
GVALIVSGGI APDLTGVGME GGAMLNDASQ IPHHRTITEA VHQEGGKIAL
100
101
QILHTGRYSY QPHLVAPSAL QAPINRFVPH ELSHEEILQL IDNFARCAQL
150
151
AREAGYDGVE VMGSEGYLIN EFLTLRTNQR SDQWGGDYRN RMRFAVEVVR
200
201
AVRERVGNDF IIIYRLSMLD LVEDGGTFAE TVELAQAIEA AGATIINTGI
250
251
GWHEARIPTI ATPVPRGAFS WVTRKLKGHV SLPLVTTNRI NDPQVADDIL
300
301
SRGDADMVSM ARPFLADAEL LSKAQSGRAD EINTCIGCNQ ACLDQIFVGK
350
351
VTSCLVNPRA CHETKMPILP AVQKKNLAVV GAGPAGLAFA INAAARGHQV
400
401
TLFDAHSEIG GQFNIAKQIP GKEEFYETLR YYRRMIEVTG VTLKLNHTVT
450
451
ADQLQAFDET ILASGIVPRT PPIDGIDHPK VLSYLDVLRD KAPVGNKVAI
500
501
IGCGGIGFDT AMYLSQPGES TSQNIAGFCN EWGIDSSLQQ AGGLSPQGMQ
550
551
IPRSPRQIVM LQRKASKPGQ GLGKTTGWIH RTTLLSRGVK MIPGVSYQKI
600
601
DDDGLHVVIN GETQVLAVDN VVICAGQEPN RALAQPLIDS GKTVHLIGGC
650
651
DVAMELDARR AIAQGTRLAL EI                              
672
 

Show the unformatted sequence.

Checksums:
CRC64:B26C7CAAACE760C3
MD5:2afeca3cbb17b27e3b293646b2d8ece8

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
FAD_binding_2 376 - 417 1PS9 A 375 - 416 Jmol OpenAstexViewer
HI0933_like 375 - 418 1PS9 A 374 - 417 Jmol OpenAstexViewer
NAD_binding_8 379 - 432 1PS9 A 378 - 431 Jmol OpenAstexViewer
Oxidored_FMN 5 - 331 1PS9 A 4 - 330 Jmol OpenAstexViewer
Pyr_redox_2 375 - 656 1PS9 A 374 - 655 Jmol OpenAstexViewer