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5  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: EAA3_HUMAN (P43005)

Summary

This is the summary of UniProt entry EAA3_HUMAN (P43005).

Description: Excitatory amino acid transporter 3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 524 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam SDF 20 465
transmembrane n/a 20 38
transmembrane n/a 58 82
low_complexity n/a 58 76
transmembrane n/a 94 116
low_complexity n/a 103 116
disorder n/a 169 176
transmembrane n/a 210 229
transmembrane n/a 250 271
transmembrane n/a 283 308
transmembrane n/a 320 341
low_complexity n/a 390 410

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P43005. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGKPARKGCE WKRFLKNNWV LLSTVAAVVL GITTGVLVRE HSNLSTLEKF
50
51
YFAFPGEILM RMLKLIILPL IISSMITGVA ALDSNVSGKI GLRAVVYYFC
100
101
TTLIAVILGI VLVVSIKPGV TQKVGEIART GSTPEVSTVD AMLDLIRNMF
150
151
PENLVQACFQ QYKTKREEVK PPSDPEMNMT EESFTAVMTT AISKNKTKEY
200
201
KIVGMYSDGI NVLGLIVFCL VFGLVIGKMG EKGQILVDFF NALSDATMKI
250
251
VQIIMCYMPL GILFLIAGKI IEVEDWEIFR KLGLYMATVL TGLAIHSIVI
300
301
LPLIYFIVVR KNPFRFAMGM AQALLTALMI SSSSATLPVT FRCAEENNQV
350
351
DKRITRFVLP VGATINMDGT ALYEAVAAVF IAQLNDLDLG IGQIITISIT
400
401
ATSASIGAAG VPQAGLVTMV IVLSAVGLPA EDVTLIIAVD WLLDRFRTMV
450
451
NVLGDAFGTG IVEKLSKKEL EQMDVSSEVN IVNPFALEST ILDNEDSDTK
500
501
KSYVNGGFAV DKSDTISFTQ TSQF                            
524
 

Show the unformatted sequence.

Checksums:
CRC64:FC6244ADC9EA228F
MD5:d3924a6c6c23942e8ae7383f0c991d9a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
SDF 20 - 465 6S3Q A 20 - 465 Show 3D Structure View in InterPro
B 20 - 465 Show 3D Structure View in InterPro
C 20 - 465 Show 3D Structure View in InterPro
6X2L A 20 - 465 Show 3D Structure View in InterPro
B 20 - 465 Show 3D Structure View in InterPro
C 20 - 465 Show 3D Structure View in InterPro
6X2Z A 20 - 465 Show 3D Structure View in InterPro
6X3E A 20 - 465 Show 3D Structure View in InterPro
B 20 - 465 Show 3D Structure View in InterPro
C 20 - 465 Show 3D Structure View in InterPro
6X3F A 20 - 465 Show 3D Structure View in InterPro
B 20 - 465 Show 3D Structure View in InterPro
C 20 - 465 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;