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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PE2R3_HUMAN (P43115)

Summary

This is the summary of UniProt entry PE2R3_HUMAN (P43115).

Description: Prostaglandin E2 receptor EP3 subtype
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 390 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 32 40
transmembrane n/a 52 75
Pfam 7tm_1 65 346
low_complexity n/a 74 87
transmembrane n/a 87 112
transmembrane n/a 132 153
transmembrane n/a 173 194
low_complexity n/a 176 197
low_complexity n/a 211 222
transmembrane n/a 228 253
low_complexity n/a 228 242
transmembrane n/a 284 307
transmembrane n/a 327 349
low_complexity n/a 369 382

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P43115. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKETRGYGGD APFCTRLNHS YTGMWAPERS AEARGNLTRP PGSGEDCGSV
50
51
SVAFPITMLL TGFVGNALAM LLVSRSYRRR ESKRKKSFLL CIGWLALTDL
100
101
VGQLLTTPVV IVVYLSKQRW EHIDPSGRLC TFFGLTMTVF GLSSLFIASA
150
151
MAVERALAIR APHWYASHMK TRATRAVLLG VWLAVLAFAL LPVLGVGQYT
200
201
VQWPGTWCFI STGRGGNGTS SSHNWGNLFF ASAFAFLGLL ALTVTFSCNL
250
251
ATIKALVSRC RAKATASQSS AQWGRITTET AIQLMGIMCV LSVCWSPLLI
300
301
MMLKMIFNQT SVEHCKTHTE KQKECNFFLI AVRLASLNQI LDPWVYLLLR
350
351
KILLRKFCQI RYHTNNYASS STSLPCQCSS TLMWSDHLER           
390
 

Show the unformatted sequence.

Checksums:
CRC64:BC76EAC78FDF5420
MD5:022c9b2dea070dd99eb79f592112a551

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
7tm_1 65 - 346 6AK3 A 65 - 346 Show 3D Structure View in InterPro
B 65 - 346 Show 3D Structure View in InterPro
6M9T A 65 - 346 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;