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9  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MSH2_HUMAN (P43246)

Summary

This is the summary of UniProt entry MSH2_HUMAN (P43246).

Description: DNA mismatch repair protein Msh2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 934 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam MutS_I 17 132
Pfam MutS_II 145 290
Pfam MutS_III 305 609
coiled_coil n/a 353 373
Pfam MutS_IV 473 569
coiled_coil n/a 478 498
coiled_coil n/a 553 576
low_complexity n/a 559 571
disorder n/a 562 565
Pfam MutS_V 665 852
low_complexity n/a 802 811

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P43246. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAVQPKETLQ LESAAEVGFV RFFQGMPEKP TTTVRLFDRG DFYTAHGEDA
50
51
LLAAREVFKT QGVIKYMGPA GAKNLQSVVL SKMNFESFVK DLLLVRQYRV
100
101
EVYKNRAGNK ASKENDWYLA YKASPGNLSQ FEDILFGNND MSASIGVVGV
150
151
KMSAVDGQRQ VGVGYVDSIQ RKLGLCEFPD NDQFSNLEAL LIQIGPKECV
200
201
LPGGETAGDM GKLRQIIQRG GILITERKKA DFSTKDIYQD LNRLLKGKKG
250
251
EQMNSAVLPE MENQVAVSSL SAVIKFLELL SDDSNFGQFE LTTFDFSQYM
300
301
KLDIAAVRAL NLFQGSVEDT TGSQSLAALL NKCKTPQGQR LVNQWIKQPL
350
351
MDKNRIEERL NLVEAFVEDA ELRQTLQEDL LRRFPDLNRL AKKFQRQAAN
400
401
LQDCYRLYQG INQLPNVIQA LEKHEGKHQK LLLAVFVTPL TDLRSDFSKF
450
451
QEMIETTLDM DQVENHEFLV KPSFDPNLSE LREIMNDLEK KMQSTLISAA
500
501
RDLGLDPGKQ IKLDSSAQFG YYFRVTCKEE KVLRNNKNFS TVDIQKNGVK
550
551
FTNSKLTSLN EEYTKNKTEY EEAQDAIVKE IVNISSGYVE PMQTLNDVLA
600
601
QLDAVVSFAH VSNGAPVPYV RPAILEKGQG RIILKASRHA CVEVQDEIAF
650
651
IPNDVYFEKD KQMFHIITGP NMGGKSTYIR QTGVIVLMAQ IGCFVPCESA
700
701
EVSIVDCILA RVGAGDSQLK GVSTFMAEML ETASILRSAT KDSLIIIDEL
750
751
GRGTSTYDGF GLAWAISEYI ATKIGAFCMF ATHFHELTAL ANQIPTVNNL
800
801
HVTALTTEET LTMLYQVKKG VCDQSFGIHV AELANFPKHV IECAKQKALE
850
851
LEEFQYIGES QGYDIMEPAA KKCYLEREQG EKIIQEFLSK VKQMPFTEMS
900
901
EENITIKLKQ LKAEVIAKNN SFVNEIISRI KVTT                 
934
 

Show the unformatted sequence.

Checksums:
CRC64:664A058C78242E05
MD5:45045a79989737b2ca578a5b3e2f049c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
MutS_I 17 - 132 2O8B A 17 - 132 Jmol OpenAstexViewer
2O8C A 17 - 132 Jmol OpenAstexViewer
2O8D A 17 - 132 Jmol OpenAstexViewer
2O8E A 17 - 132 Jmol OpenAstexViewer
2O8F A 17 - 132 Jmol OpenAstexViewer
3THW A 17 - 132 Jmol OpenAstexViewer
3THX A 17 - 132 Jmol OpenAstexViewer
3THY A 17 - 132 Jmol OpenAstexViewer
3THZ A 17 - 132 Jmol OpenAstexViewer
MutS_II 145 - 290 2O8B A 145 - 290 Jmol OpenAstexViewer
2O8C A 145 - 290 Jmol OpenAstexViewer
2O8D A 145 - 290 Jmol OpenAstexViewer
2O8E A 145 - 290 Jmol OpenAstexViewer
2O8F A 145 - 290 Jmol OpenAstexViewer
3THW A 145 - 290 Jmol OpenAstexViewer
3THX A 145 - 290 Jmol OpenAstexViewer
3THY A 145 - 290 Jmol OpenAstexViewer
3THZ A 145 - 290 Jmol OpenAstexViewer
MutS_III 305 - 609 2O8B A 305 - 609 Jmol OpenAstexViewer
2O8C A 305 - 609 Jmol OpenAstexViewer
2O8D A 305 - 609 Jmol OpenAstexViewer
2O8E A 305 - 609 Jmol OpenAstexViewer
2O8F A 305 - 609 Jmol OpenAstexViewer
3THW A 305 - 609 Jmol OpenAstexViewer
3THX A 305 - 609 Jmol OpenAstexViewer
3THY A 305 - 609 Jmol OpenAstexViewer
3THZ A 305 - 609 Jmol OpenAstexViewer
MutS_IV 473 - 569 2O8B A 473 - 569 Jmol OpenAstexViewer
2O8C A 473 - 569 Jmol OpenAstexViewer
2O8D A 473 - 569 Jmol OpenAstexViewer
2O8E A 473 - 569 Jmol OpenAstexViewer
2O8F A 473 - 569 Jmol OpenAstexViewer
3THW A 473 - 569 Jmol OpenAstexViewer
3THX A 473 - 569 Jmol OpenAstexViewer
3THY A 473 - 569 Jmol OpenAstexViewer
3THZ A 473 - 569 Jmol OpenAstexViewer
MutS_V 665 - 852 2O8B A 665 - 852 Jmol OpenAstexViewer
2O8C A 665 - 852 Jmol OpenAstexViewer
2O8D A 665 - 852 Jmol OpenAstexViewer
2O8E A 665 - 852 Jmol OpenAstexViewer
2O8F A 665 - 852 Jmol OpenAstexViewer
3THW A 665 - 852 Jmol OpenAstexViewer
3THX A 665 - 852 Jmol OpenAstexViewer
3THY A 665 - 852 Jmol OpenAstexViewer
3THZ A 665 - 852 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.