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7  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: ZAP70_HUMAN (P43403)

Summary

This is the summary of UniProt entry ZAP70_HUMAN (P43403).

Description: Tyrosine-protein kinase ZAP-70 EC=2.7.10.2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 619 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam SH2 10 87
disorder n/a 98 102
Pfam SH2 163 239
low_complexity n/a 255 266
disorder n/a 260 319
Pfam Pkinase_Tyr 338 593
disorder n/a 380 386
disorder n/a 615 616

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P43403. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPDPAAHLPF FYGSISRAEA EEHLKLAGMA DGLFLLRQCL RSLGGYVLSL
50
51
VHDVRFHHFP IERQLNGTYA IAGGKAHCGP AELCEFYSRD PDGLPCNLRK
100
101
PCNRPSGLEP QPGVFDCLRD AMVRDYVRQT WKLEGEALEQ AIISQAPQVE
150
151
KLIATTAHER MPWYHSSLTR EEAERKLYSG AQTDGKFLLR PRKEQGTYAL
200
201
SLIYGKTVYH YLISQDKAGK YCIPEGTKFD TLWQLVEYLK LKADGLIYCL
250
251
KEACPNSSAS NASGAAAPTL PAHPSTLTHP QRRIDTLNSD GYTPEPARIT
300
301
SPDKPRPMPM DTSVYESPYS DPEELKDKKL FLKRDNLLIA DIELGCGNFG
350
351
SVRQGVYRMR KKQIDVAIKV LKQGTEKADT EEMMREAQIM HQLDNPYIVR
400
401
LIGVCQAEAL MLVMEMAGGG PLHKFLVGKR EEIPVSNVAE LLHQVSMGMK
450
451
YLEEKNFVHR DLAARNVLLV NRHYAKISDF GLSKALGADD SYYTARSAGK
500
501
WPLKWYAPEC INFRKFSSRS DVWSYGVTMW EALSYGQKPY KKMKGPEVMA
550
551
FIEQGKRMEC PPECPPELYA LMSDCWIYKW EDRPDFLTVE QRMRACYYSL
600
601
ASKVEGPPGS TQKAEAACA                                  
619
 

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Checksums:
CRC64:D1E1A8EC66FA116F
MD5:e3b2d80f9b7f4b32b0d58fa7a52e2d11

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase_Tyr 338 - 593 1U59 A 338 - 593 Jmol OpenAstexViewer
2OZO A 338 - 593 Jmol OpenAstexViewer
4K2R A 338 - 593 Jmol OpenAstexViewer
SH2 10 - 87 1M61 A 10 - 87 Jmol OpenAstexViewer
2OQ1 A 12 - 89 Jmol OpenAstexViewer
2OZO A 10 - 87 Jmol OpenAstexViewer
4K2R A 10 - 87 Jmol OpenAstexViewer
4XZ0 A 10 - 87 Jmol OpenAstexViewer
4XZ1 A 10 - 87 Jmol OpenAstexViewer
163 - 239 1M61 A 163 - 239 Jmol OpenAstexViewer
2OQ1 A 165 - 241 Jmol OpenAstexViewer
2OZO A 163 - 239 Jmol OpenAstexViewer
4K2R A 163 - 239 Jmol OpenAstexViewer
4XZ0 A 163 - 239 Jmol OpenAstexViewer
4XZ1 A 163 - 239 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.