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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NKX21_HUMAN (P43699)

Summary

This is the summary of UniProt entry NKX21_HUMAN (P43699).

Description: Homeobox protein Nkx-2.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 371 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 5
disorder n/a 10 15
disorder n/a 38 58
low_complexity n/a 55 68
disorder n/a 94 113
disorder n/a 115 116
disorder n/a 125 128
low_complexity n/a 132 146
disorder n/a 139 144
disorder n/a 146 162
Pfam Homeodomain 162 218
disorder n/a 167 168
disorder n/a 180 182
disorder n/a 184 188
disorder n/a 191 197
disorder n/a 211 213
disorder n/a 216 302
low_complexity n/a 225 252
low_complexity n/a 271 279
low_complexity n/a 277 321
disorder n/a 305 350
low_complexity n/a 344 354

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P43699. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSMSPKHTTP FSVSDILSPL EESYKKVGME GGGLGAPLAA YRQGQAAPPT
50
51
AAMQQHAVGH HGAVTAAYHM TAAGVPQLSH SAVGGYCNGN LGNMSELPPY
100
101
QDTMRNSASG PGWYGANPDP RFPAISRFMG PASGMNMSGM GGLGSLGDVS
150
151
KNMAPLPSAP RRKRRVLFSQ AQVYELERRF KQQKYLSAPE REHLASMIHL
200
201
TPTQVKIWFQ NHRYKMKRQA KDKAAQQQLQ QDSGGGGGGG GTGCPQQQQA
250
251
QQQSPRRVAV PVLVKDGKPC QAGAPAPGAA SLQGHAQQQA QHQAQAAQAA
300
301
AAAISVGSGG AGLGAHPGHQ PGSAGQSPDL AHHAASPAAL QGQVSSLSHL
350
351
NSSGSDYGTM SCSTLLYGRT W                               
371
 

Show the unformatted sequence.

Checksums:
CRC64:5F1E3B40A1BBD862
MD5:6c36d759fd6d6ea4291c848b8d1b6a27

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.