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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CBX5_HUMAN (P45973)

Summary

This is the summary of UniProt entry CBX5_HUMAN (P45973).

Description: Chromobox protein homolog 5
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 191 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 19
low_complexity n/a 10 19
Pfam Chromo 20 69
disorder n/a 73 109
disorder n/a 112 115
Pfam Chromo_shadow 123 174
disorder n/a 178 191

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P45973. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGKKTKRTAD SSSSEDEEEY VVEKVLDRRV VKGQVEYLLK WKGFSEEHNT
50
51
WEPEKNLDCP ELISEFMKKY KKMKEGENNK PREKSESNKR KSNFSNSADD
100
101
IKSKKKREQS NDIARGFERG LEPEKIIGAT DSCGDLMFLM KWKDTDEADL
150
151
VLAKEANVKC PQIVIAFYEE RLTWHAYPED AENKEKETAK S         
191
 

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Checksums:
CRC64:16FFC476367093B1
MD5:54c128b4135582d57ee07b0ac0798bf7

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Chromo 20 - 68 3FDT A 4 - 52 Show 3D Structure View in InterPro
Chromo_shadow 123 - 170 3I3C A 25 - 72 Show 3D Structure View in InterPro
C 25 - 72 Show 3D Structure View in InterPro
D 25 - 72 Show 3D Structure View in InterPro
123 - 171 3I3C B 25 - 73 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;