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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: RECQ1_HUMAN (P46063)

Summary

This is the summary of UniProt entry RECQ1_HUMAN (P46063).

Description: ATP-dependent DNA helicase Q1 EC=3.6.4.12
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 649 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
coiled_coil n/a 4 45
low_complexity n/a 34 47
disorder n/a 60 61
Pfam DEAD 93 264
Pfam Helicase_C 299 409
Pfam RecQ_Zn_bind 420 479
coiled_coil n/a 489 509
disorder n/a 590 594
disorder n/a 596 649

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P46063. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASVSALTEE LDSITSELHA VEIQIQELTE RQQELIQKKK VLTKKIKQCL
50
51
EDSDAGASNE YDSSPAAWNK EDFPWSGKVK DILQNVFKLE KFRPLQLETI
100
101
NVTMAGKEVF LVMPTGGGKS LCYQLPALCS DGFTLVICPL ISLMEDQLMV
150
151
LKQLGISATM LNASSSKEHV KWVHAEMVNK NSELKLIYVT PEKIAKSKMF
200
201
MSRLEKAYEA RRFTRIAVDE VHCCSQWGHD FRPDYKALGI LKRQFPNASL
250
251
IGLTATATNH VLTDAQKILC IEKCFTFTAS FNRPNLYYEV RQKPSNTEDF
300
301
IEDIVKLING RYKGQSGIIY CFSQKDSEQV TVSLQNLGIH AGAYHANLEP
350
351
EDKTTVHRKW SANEIQVVVA TVAFGMGIDK PDVRFVIHHS MSKSMENYYQ
400
401
ESGRAGRDDM KADCILYYGF GDIFRISSMV VMENVGQQKL YEMVSYCQNI
450
451
SKCRRVLMAQ HFDEVWNSEA CNKMCDNCCK DSAFERKNIT EYCRDLIKIL
500
501
KQAEELNEKL TPLKLIDSWM GKGAAKLRVA GVVAPTLPRE DLEKIIAHFL
550
551
IQQYLKEDYS FTAYATISYL KIGPKANLLN NEAHAITMQV TKSTQNSFRA
600
601
ESSQTCHSEQ GDKKMEEKNS GNFQKKAANM LQQSGSKNTG AKKRKIDDA 
649
 

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Checksums:
CRC64:F616DC3191F79391
MD5:8e64f7f6c47911ee21d4056a5b1b794c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DEAD 93 - 264 2V1X A 93 - 264 Jmol OpenAstexViewer
B 93 - 264 Jmol OpenAstexViewer
2WWY A 93 - 264 Jmol OpenAstexViewer
B 93 - 264 Jmol OpenAstexViewer
4U7D A 93 - 264 Jmol OpenAstexViewer
B 93 - 264 Jmol OpenAstexViewer
C 93 - 264 Jmol OpenAstexViewer
D 93 - 264 Jmol OpenAstexViewer
Helicase_C 299 - 409 2V1X A 299 - 409 Jmol OpenAstexViewer
B 299 - 409 Jmol OpenAstexViewer
2WWY A 299 - 409 Jmol OpenAstexViewer
B 299 - 409 Jmol OpenAstexViewer
4U7D A 299 - 409 Jmol OpenAstexViewer
B 299 - 409 Jmol OpenAstexViewer
C 299 - 409 Jmol OpenAstexViewer
D 299 - 409 Jmol OpenAstexViewer
RecQ_Zn_bind 420 - 479 2V1X A 420 - 479 Jmol OpenAstexViewer
B 420 - 479 Jmol OpenAstexViewer
2WWY A 420 - 479 Jmol OpenAstexViewer
B 420 - 479 Jmol OpenAstexViewer
4U7D A 420 - 479 Jmol OpenAstexViewer
B 420 - 479 Jmol OpenAstexViewer
C 420 - 479 Jmol OpenAstexViewer
D 420 - 479 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.