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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CDN1B_HUMAN (P46527)

Summary

This is the summary of UniProt entry CDN1B_HUMAN (P46527).

Description: Cyclin-dependent kinase inhibitor 1B
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 198 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 37
Pfam CDI 31 79
coiled_coil n/a 38 58
disorder n/a 40 64
disorder n/a 66 67
disorder n/a 71 77
disorder n/a 81 198

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P46527. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSNVRVSNGS PSLERMDARQ AEHPKPSACR NLFGPVDHEE LTRDLEKHCR
50
51
DMEEASQRKW NFDFQNHKPL EGKYEWQEVE KGSLPEFYYR PPRPPKGACK
100
101
VPAQESQDVS GSRPAAPLIG APANSEDTHL VDPKTDPSDS QTGLAEQCAG
150
151
IRKRPATDDS STQNKRANRT EENVSDGSPN AGSVEQTPKK PGLRRRQT  
198
 

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Checksums:
CRC64:1118D58901CDF3FC
MD5:6f7ef22c357ff0479884f9fe0d100a19

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
CDI 31 - 35 1H27 E 31 - 35 Jmol OpenAstexViewer
31 - 79 1JSU C 31 - 79 Jmol OpenAstexViewer
51 - 79 5UQ3 C 557 - 585 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.