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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AIP1_YEAST (P46680)

Summary

This is the summary of UniProt entry AIP1_YEAST (P46680).

Description: Actin-interacting protein 1
Source organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (NCBI taxonomy ID 559292)
Length: 615 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 17 18
disorder n/a 20 22
Pfam WD40 54 93
Pfam WD40 329 363
low_complexity n/a 548 553

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P46680. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSSISLKEII PPQPSTQRNF TTHLSYDPTT NAIAYPCGKS AFVRCLDDGD
50
51
SKVPPVVQFT GHGSSVVTTV KFSPIKGSQY LCSGDESGKV IVWGWTFDKE
100
101
SNSVEVNVKS EFQVLAGPIS DISWDFEGRR LCVVGEGRDN FGVFISWDSG
150
151
NSLGEVSGHS QRINACHLKQ SRPMRSMTVG DDGSVVFYQG PPFKFSASDR
200
201
THHKQGSFVR DVEFSPDSGE FVITVGSDRK ISCFDGKSGE FLKYIEDDQE
250
251
PVQGGIFALS WLDSQKFATV GADATIRVWD VTTSKCVQKW TLDKQQLGNQ
300
301
QVGVVATGNG RIISLSLDGT LNFYELGHDE VLKTISGHNK GITALTVNPL
350
351
ISGSYDGRIM EWSSSSMHQD HSNLIVSLDN SKAQEYSSIS WDDTLKVNGI
400
401
TKHEFGSQPK VASANNDGFT AVLTNDDDLL ILQSFTGDII KSVRLNSPGS
450
451
AVSLSQNYVA VGLEEGNTIQ VFKLSDLEVS FDLKTPLRAK PSYISISPSE
500
501
TYIAAGDVMG KILLYDLQSR EVKTSRWAFH TSKINAISWK PAEKGANEEE
550
551
IEEDLVATGS LDTNIFIYSV KRPMKIIKAL NAHKDGVNNL LWETPSTLVS
600
601
SGADACIKRW NVVLE                                      
615
 

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Checksums:
CRC64:B8340BF68DD08257
MD5:2e5f6b33d570ccfc095ce5f7f2a08a99

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
WD40 329 - 363 1PGU A 329 - 363 Show 3D Structure View in InterPro
B 329 - 363 Show 3D Structure View in InterPro
1PI6 A 329 - 363 Show 3D Structure View in InterPro
54 - 93 1PGU A 54 - 93 Show 3D Structure View in InterPro
B 54 - 93 Show 3D Structure View in InterPro
1PI6 A 54 - 93 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;