Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SO1A2_HUMAN (P46721)

Summary

This is the summary of UniProt entry SO1A2_HUMAN (P46721).

Description: Solute carrier organic anion transporter family member 1A2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 670 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam OATP 21 597
transmembrane n/a 21 40
transmembrane n/a 60 80
transmembrane n/a 87 105
transmembrane n/a 157 183
transmembrane n/a 195 222
low_complexity n/a 202 214
transmembrane n/a 242 266
coiled_coil n/a 272 292
disorder n/a 281 282
low_complexity n/a 283 298
disorder n/a 286 287
transmembrane n/a 317 339
transmembrane n/a 354 376
transmembrane n/a 388 408
low_complexity n/a 394 407
Pfam Kazal_2 440 486
transmembrane n/a 512 536
transmembrane n/a 548 569
transmembrane n/a 600 623

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P46721. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGETEKRIET HRIRCLSKLK MFLLAITCAF VSKTLSGSYM NSMLTQIERQ
50
51
FNIPTSLVGF INGSFEIGNL LLIIFVSYFG TKLHRPIMIG IGCVVMGLGC
100
101
FLKSLPHFLM NQYEYESTVS VSGNLSSNSF LCMENGTQIL RPTQDPSECT
150
151
KEVKSLMWVY VLVGNIVRGM GETPILPLGI SYIEDFAKFE NSPLYIGLVE
200
201
TGAIIGPLIG LLLASFCANV YVDTGFVNTD DLIITPTDTR WVGAWWFGFL
250
251
ICAGVNVLTA IPFFFLPNTL PKEGLETNAD IIKNENEDKQ KEEVKKEKYG
300
301
ITKDFLPFMK SLSCNPIYML FILVSVIQFN AFVNMISFMP KYLEQQYGIS
350
351
SSDAIFLMGI YNLPPICIGY IIGGLIMKKF KITVKQAAHI GCWLSLLEYL
400
401
LYFLSFLMTC ENSSVVGINT SYEGIPQDLY VENDIFADCN VDCNCPSKIW
450
451
DPVCGNNGLS YLSACLAGCE TSIGTGINMV FQNCSCIQTS GNSSAVLGLC
500
501
DKGPDCSLML QYFLILSAMS SFIYSLAAIP GYMVLLRCMK SEEKSLGVGL
550
551
HTFCTRVFAG IPAPIYFGAL MDSTCLHWGT LKCGESGACR IYDSTTFRYI
600
601
YLGLPAALRG SSFVPALIIL ILLRKCHLPG ENASSGTELI ETKVKGKENE
650
651
CKDIYQKSTV LKDDELKTKL                                 
670
 

Show the unformatted sequence.

Checksums:
CRC64:C3A740CEF1E6F129
MD5:14cb94d67aa0da0902c080335a40d67b

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;