Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: UTRN_HUMAN (P46939)

Summary

This is the summary of UniProt entry UTRN_HUMAN (P46939).

Description: Utrophin {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 3433 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
disorder n/a 1 25
Pfam CH 31 136
low_complexity n/a 58 78
disorder n/a 83 85
Pfam CH 150 256
disorder n/a 279 306
Pfam Spectrin 309 417
disorder n/a 336 345
disorder n/a 381 384
disorder n/a 388 389
Pfam Spectrin 418 526
low_complexity n/a 422 430
coiled_coil n/a 453 476
low_complexity n/a 530 541
coiled_coil n/a 573 593
disorder n/a 587 588
disorder n/a 604 605
disorder n/a 608 609
disorder n/a 611 612
disorder n/a 638 641
disorder n/a 663 685
low_complexity n/a 672 677
disorder n/a 717 719
disorder n/a 721 722
disorder n/a 726 757
low_complexity n/a 728 737
disorder n/a 759 760
disorder n/a 767 768
coiled_coil n/a 773 813
disorder n/a 825 826
disorder n/a 831 837
disorder n/a 861 862
disorder n/a 894 907
coiled_coil n/a 940 960
disorder n/a 968 972
Pfam Spectrin 1016 1122
low_complexity n/a 1042 1051
coiled_coil n/a 1099 1147
disorder n/a 1117 1118
disorder n/a 1120 1122
disorder n/a 1124 1128
Pfam Spectrin 1125 1230
disorder n/a 1131 1132
coiled_coil n/a 1161 1188
disorder n/a 1166 1168
disorder n/a 1260 1261
disorder n/a 1263 1264
low_complexity n/a 1293 1307
coiled_coil n/a 1339 1359
coiled_coil n/a 1377 1397
disorder n/a 1395 1419
disorder n/a 1501 1513
disorder n/a 1515 1516
coiled_coil n/a 1532 1552
disorder n/a 1543 1544
Pfam Spectrin 1544 1649
Pfam Spectrin 1652 1753
coiled_coil n/a 1690 1710
coiled_coil n/a 1730 1750
coiled_coil n/a 1775 1795
disorder n/a 1793 1825
low_complexity n/a 1794 1806
coiled_coil n/a 1910 1930
Pfam Spectrin 1976 2081
disorder n/a 2080 2081
disorder n/a 2083 2084
disorder n/a 2110 2124
coiled_coil n/a 2122 2142
disorder n/a 2193 2194
Pfam Spectrin 2230 2333
coiled_coil n/a 2259 2279
disorder n/a 2270 2271
disorder n/a 2300 2301
disorder n/a 2304 2305
coiled_coil n/a 2345 2365
Pfam Spectrin 2444 2556
coiled_coil n/a 2485 2505
disorder n/a 2520 2521
coiled_coil n/a 2551 2571
disorder n/a 2585 2587
disorder n/a 2628 2662
coiled_coil n/a 2686 2713
Pfam Spectrin 2691 2797
disorder n/a 2704 2705
disorder n/a 2707 2711
Pfam WW 2815 2843
Pfam EF-hand_2 2846 2964
Pfam EF-hand_3 2968 3059
Pfam ZZ 3064 3109
disorder n/a 3180 3190
disorder n/a 3196 3200
disorder n/a 3205 3220
disorder n/a 3222 3224
disorder n/a 3226 3230
disorder n/a 3233 3258
coiled_coil n/a 3253 3287
low_complexity n/a 3256 3265
disorder n/a 3262 3269
disorder n/a 3277 3322
coiled_coil n/a 3325 3359
disorder n/a 3326 3341
disorder n/a 3343 3368
disorder n/a 3371 3414
disorder n/a 3416 3433

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P46939. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAKYGEHEAS PDNGQNEFSD IIKSRSDEHN DVQKKTFTKW INARFSKSGK
50
51
PPINDMFTDL KDGRKLLDLL EGLTGTSLPK ERGSTRVHAL NNVNRVLQVL
100
101
HQNNVELVNI GGTDIVDGNH KLTLGLLWSI ILHWQVKDVM KDVMSDLQQT
150
151
NSEKILLSWV RQTTRPYSQV NVLNFTTSWT DGLAFNAVLH RHKPDLFSWD
200
201
KVVKMSPIER LEHAFSKAQT YLGIEKLLDP EDVAVQLPDK KSIIMYLTSL
250
251
FEVLPQQVTI DAIREVETLP RKYKKECEEE AINIQSTAPE EEHESPRAET
300
301
PSTVTEVDMD LDSYQIALEE VLTWLLSAED TFQEQDDISD DVEEVKDQFA
350
351
THEAFMMELT AHQSSVGSVL QAGNQLITQG TLSDEEEFEI QEQMTLLNAR
400
401
WEALRVESMD RQSRLHDVLM ELQKKQLQQL SAWLTLTEER IQKMETCPLD
450
451
DDVKSLQKLL EEHKSLQSDL EAEQVKVNSL THMVVIVDEN SGESATAILE
500
501
DQLQKLGERW TAVCRWTEER WNRLQEINIL WQELLEEQCL LKAWLTEKEE
550
551
ALNKVQTSNF KDQKELSVSV RRLAILKEDM EMKRQTLDQL SEIGQDVGQL
600
601
LDNSKASKKI NSDSEELTQR WDSLVQRLED SSNQVTQAVA KLGMSQIPQK
650
651
DLLETVRVRE QAITKKSKQE LPPPPPPKKR QIHVDIEAKK KFDAISAELL
700
701
NWILKWKTAI QTTEIKEYMK MQDTSEMKKK LKALEKEQRE RIPRADELNQ
750
751
TGQILVEQMG KEGLPTEEIK NVLEKVSSEW KNVSQHLEDL ERKIQLQEDI
800
801
NAYFKQLDEL EKVIKTKEEW VKHTSISESS RQSLPSLKDS CQRELTNLLG
850
851
LHPKIEMARA SCSALMSQPS APDFVQRGFD SFLGRYQAVQ EAVEDRQQHL
900
901
ENELKGQPGH AYLETLKTLK DVLNDSENKA QVSLNVLNDL AKVEKALQEK
950
951
KTLDEILENQ KPALHKLAEE TKALEKNVHP DVEKLYKQEF DDVQGKWNKL
1000
1001
KVLVSKDLHL LEEIALTLRA FEADSTVIEK WMDGVKDFLM KQQAAQGDDA
1050
1051
GLQRQLDQCS AFVNEIETIE SSLKNMKEIE TNLRSGPVAG IKTWVQTRLG
1100
1101
DYQTQLEKLS KEIATQKSRL SESQEKAANL KKDLAEMQEW MTQAEEEYLE
1150
1151
RDFEYKSPEE LESAVEEMKR AKEDVLQKEV RVKILKDNIK LLAAKVPSGG
1200
1201
QELTSELNVV LENYQLLCNR IRGKCHTLEE VWSCWIELLH YLDLETTWLN
1250
1251
TLEERMKSTE VLPEKTDAVN EALESLESVL RHPADNRTQI RELGQTLIDG
1300
1301
GILDDIISEK LEAFNSRYED LSHLAESKQI SLEKQLQVLR ETDQMLQVLQ
1350
1351
ESLGELDKQL TTYLTDRIDA FQVPQEAQKI QAEISAHELT LEELRRNMRS
1400
1401
QPLTSPESRT ARGGSQMDVL QRKLREVSTK FQLFQKPANF EQRMLDCKRV
1450
1451
LDGVKAELHV LDVKDVDPDV IQTHLDKCMK LYKTLSEVKL EVETVIKTGR
1500
1501
HIVQKQQTDN PKGMDEQLTS LKVLYNDLGA QVTEGKQDLE RASQLARKMK
1550
1551
KEAASLSEWL SATETELVQK STSEGLLGDL DTEISWAKNV LKDLEKRKAD
1600
1601
LNTITESSAA LQNLIEGSEP ILEERLCVLN AGWSRVRTWT EDWCNTLMNH
1650
1651
QNQLEIFDGN VAHISTWLYQ AEALLDEIEK KPTSKQEEIV KRLVSELDDA
1700
1701
NLQVENVRDQ ALILMNARGS SSRELVEPKL AELNRNFEKV SQHIKSAKLL
1750
1751
IAQEPLYQCL VTTETFETGV PFSDLEKLEN DIENMLKFVE KHLESSDEDE
1800
1801
KMDEESAQIE EVLQRGEEML HQPMEDNKKE KIRLQLLLLH TRYNKIKAIP
1850
1851
IQQRKMGQLA SGIRSSLLPT DYLVEINKIL LCMDDVELSL NVPELNTAIY
1900
1901
EDFSFQEDSL KNIKDQLDKL GEQIAVIHEK QPDVILEASG PEAIQIRDTL
1950
1951
TQLNAKWDRI NRMYSDRKGC FDRAMEEWRQ FHCDLNDLTQ WITEAEELLV
2000
2001
DTCAPGGSLD LEKARIHQQE LEVGISSHQP SFAALNRTGD GIVQKLSQAD
2050
2051
GSFLKEKLAG LNQRWDAIVA EVKDRQPRLK GESKQVMKYR HQLDEIICWL
2100
2101
TKAEHAMQKR STTELGENLQ ELRDLTQEME VHAEKLKWLN RTELEMLSDK
2150
2151
SLSLPERDKI SESLRTVNMT WNKICREVPT TLKECIQEPS SVSQTRIAAH
2200
2201
PNVQKVVLVS SASDIPVQSH RTSEISIPAD LDKTITELAD WLVLIDQMLK
2250
2251
SNIVTVGDVE EINKTVSRMK ITKADLEQRH PQLDYVFTLA QNLKNKASSS
2300
2301
DMRTAITEKL ERVKNQWDGT QHGVELRQQQ LEDMIIDSLQ WDDHREETEE
2350
2351
LMRKYEARLY ILQQARRDPL TKQISDNQIL LQELGPGDGI VMAFDNVLQK
2400
2401
LLEEYGSDDT RNVKETTEYL KTSWINLKQS IADRQNALEA EWRTVQASRR
2450
2451
DLENFLKWIQ EAETTVNVLV DASHRENALQ DSILARELKQ QMQDIQAEID
2500
2501
AHNDIFKSID GNRQKMVKAL GNSEEATMLQ HRLDDMNQRW NDLKAKSASI
2550
2551
RAHLEASAEK WNRLLMSLEE LIKWLNMKDE ELKKQMPIGG DVPALQLQYD
2600
2601
HCKALRRELK EKEYSVLNAV DQARVFLADQ PIEAPEEPRR NLQSKTELTP
2650
2651
EERAQKIAKA MRKQSSEVKE KWESLNAVTS NWQKQVDKAL EKLRDLQGAM
2700
2701
DDLDADMKEA ESVRNGWKPV GDLLIDSLQD HIEKIMAFRE EIAPINFKVK
2750
2751
TVNDLSSQLS PLDLHPSLKM SRQLDDLNMR WKLLQVSVDD RLKQLQEAHR
2800
2801
DFGPSSQHFL STSVQLPWQR SISHNKVPYY INHQTQTTCW DHPKMTELFQ
2850
2851
SLADLNNVRF SAYRTAIKIR RLQKALCLDL LELSTTNEIF KQHKLNQNDQ
2900
2901
LLSVPDVINC LTTTYDGLEQ MHKDLVNVPL CVDMCLNWLL NVYDTGRTGK
2950
2951
IRVQSLKIGL MSLSKGLLEE KYRYLFKEVA GPTEMCDQRQ LGLLLHDAIQ
3000
3001
IPRQLGEVAA FGGSNIEPSV RSCFQQNNNK PEISVKEFID WMHLEPQSMV
3050
3051
WLPVLHRVAA AETAKHQAKC NICKECPIVG FRYRSLKHFN YDVCQSCFFS
3100
3101
GRTAKGHKLH YPMVEYCIPT TSGEDVRDFT KVLKNKFRSK KYFAKHPRLG
3150
3151
YLPVQTVLEG DNLETPITLI SMWPEHYDPS QSPQLFHDDT HSRIEQYATR
3200
3201
LAQMERTNGS FLTDSSSTTG SVEDEHALIQ QYCQTLGGES PVSQPQSPAQ
3250
3251
ILKSVEREER GELERIIADL EEEQRNLQVE YEQLKDQHLR RGLPVGSPPE
3300
3301
SIISPHHTSE DSELIAEAKL LRQHKGRLEA RMQILEDHNK QLESQLHRLR
3350
3351
QLLEQPESDS RINGVSPWAS PQHSALSYSL DPDASGPQFH QAAGEDLLAP
3400
3401
PHDTSTDLTE VMEQIHSTFP SCCPNVPSRP QAM                  
3433
 

Show the unformatted sequence.

Checksums:
CRC64:C72CADE8CD666993
MD5:b82b3aa61ace43983819af3a8cd1ebb1

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
CH 150 - 254 1BHD A 150 - 254 Show 3D Structure View in InterPro
150 - 256 1QAG A 150 - 256 Show 3D Structure View in InterPro
B 150 - 256 Show 3D Structure View in InterPro
151 - 256 1BHD B 151 - 256 Show 3D Structure View in InterPro
31 - 135 6M5G F 31 - 135 Show 3D Structure View in InterPro
G 31 - 135 Show 3D Structure View in InterPro
H 31 - 135 Show 3D Structure View in InterPro
31 - 136 1QAG A 31 - 136 Show 3D Structure View in InterPro
B 31 - 136 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.