Summary
This is the summary of UniProt entry UTRN_HUMAN (P46939).
| Description: | Utrophin {ECO:0000305} |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 3433 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
Show or hide the data used to generate the graphic in JSON format.
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 1 | 25 |
| Pfam | CH | 31 | 136 |
| low_complexity | n/a | 58 | 78 |
| disorder | n/a | 83 | 85 |
| Pfam | CH | 150 | 256 |
| disorder | n/a | 279 | 306 |
| Pfam | Spectrin | 309 | 417 |
| disorder | n/a | 336 | 345 |
| disorder | n/a | 381 | 384 |
| disorder | n/a | 388 | 389 |
| Pfam | Spectrin | 418 | 526 |
| low_complexity | n/a | 422 | 430 |
| coiled_coil | n/a | 453 | 476 |
| low_complexity | n/a | 530 | 541 |
| coiled_coil | n/a | 573 | 593 |
| disorder | n/a | 587 | 588 |
| disorder | n/a | 604 | 605 |
| disorder | n/a | 608 | 609 |
| disorder | n/a | 611 | 612 |
| disorder | n/a | 638 | 641 |
| disorder | n/a | 663 | 685 |
| low_complexity | n/a | 672 | 677 |
| disorder | n/a | 717 | 719 |
| disorder | n/a | 721 | 722 |
| disorder | n/a | 726 | 757 |
| low_complexity | n/a | 728 | 737 |
| disorder | n/a | 759 | 760 |
| disorder | n/a | 767 | 768 |
| coiled_coil | n/a | 773 | 813 |
| disorder | n/a | 825 | 826 |
| disorder | n/a | 831 | 837 |
| disorder | n/a | 861 | 862 |
| disorder | n/a | 894 | 907 |
| coiled_coil | n/a | 940 | 960 |
| disorder | n/a | 968 | 972 |
| Pfam | Spectrin | 1016 | 1122 |
| low_complexity | n/a | 1042 | 1051 |
| coiled_coil | n/a | 1099 | 1147 |
| disorder | n/a | 1117 | 1118 |
| disorder | n/a | 1120 | 1122 |
| disorder | n/a | 1124 | 1128 |
| Pfam | Spectrin | 1125 | 1230 |
| disorder | n/a | 1131 | 1132 |
| coiled_coil | n/a | 1161 | 1188 |
| disorder | n/a | 1166 | 1168 |
| disorder | n/a | 1260 | 1261 |
| disorder | n/a | 1263 | 1264 |
| low_complexity | n/a | 1293 | 1307 |
| coiled_coil | n/a | 1339 | 1359 |
| coiled_coil | n/a | 1377 | 1397 |
| disorder | n/a | 1395 | 1419 |
| disorder | n/a | 1501 | 1513 |
| disorder | n/a | 1515 | 1516 |
| coiled_coil | n/a | 1532 | 1552 |
| disorder | n/a | 1543 | 1544 |
| Pfam | Spectrin | 1544 | 1649 |
| Pfam | Spectrin | 1652 | 1753 |
| coiled_coil | n/a | 1690 | 1710 |
| coiled_coil | n/a | 1730 | 1750 |
| coiled_coil | n/a | 1775 | 1795 |
| disorder | n/a | 1793 | 1825 |
| low_complexity | n/a | 1794 | 1806 |
| coiled_coil | n/a | 1910 | 1930 |
| Pfam | Spectrin | 1976 | 2081 |
| disorder | n/a | 2080 | 2081 |
| disorder | n/a | 2083 | 2084 |
| disorder | n/a | 2110 | 2124 |
| coiled_coil | n/a | 2122 | 2142 |
| disorder | n/a | 2193 | 2194 |
| Pfam | Spectrin | 2230 | 2333 |
| coiled_coil | n/a | 2259 | 2279 |
| disorder | n/a | 2270 | 2271 |
| disorder | n/a | 2300 | 2301 |
| disorder | n/a | 2304 | 2305 |
| coiled_coil | n/a | 2345 | 2365 |
| Pfam | Spectrin | 2444 | 2556 |
| coiled_coil | n/a | 2485 | 2505 |
| disorder | n/a | 2520 | 2521 |
| coiled_coil | n/a | 2551 | 2571 |
| disorder | n/a | 2585 | 2587 |
| disorder | n/a | 2628 | 2662 |
| coiled_coil | n/a | 2686 | 2713 |
| Pfam | Spectrin | 2691 | 2797 |
| disorder | n/a | 2704 | 2705 |
| disorder | n/a | 2707 | 2711 |
| Pfam | WW | 2815 | 2843 |
| Pfam | EF-hand_2 | 2846 | 2964 |
| Pfam | EF-hand_3 | 2968 | 3059 |
| Pfam | ZZ | 3064 | 3109 |
| disorder | n/a | 3180 | 3190 |
| disorder | n/a | 3196 | 3200 |
| disorder | n/a | 3205 | 3220 |
| disorder | n/a | 3222 | 3224 |
| disorder | n/a | 3226 | 3230 |
| disorder | n/a | 3233 | 3258 |
| coiled_coil | n/a | 3253 | 3287 |
| low_complexity | n/a | 3256 | 3265 |
| disorder | n/a | 3262 | 3269 |
| disorder | n/a | 3277 | 3322 |
| coiled_coil | n/a | 3325 | 3359 |
| disorder | n/a | 3326 | 3341 |
| disorder | n/a | 3343 | 3368 |
| disorder | n/a | 3371 | 3414 |
| disorder | n/a | 3416 | 3433 |
Show or hide domain scores.
Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P46939. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MAKYGEHEAS PDNGQNEFSD IIKSRSDEHN DVQKKTFTKW INARFSKSGK
50 51
PPINDMFTDL KDGRKLLDLL EGLTGTSLPK ERGSTRVHAL NNVNRVLQVL
100 101
HQNNVELVNI GGTDIVDGNH KLTLGLLWSI ILHWQVKDVM KDVMSDLQQT
150 151
NSEKILLSWV RQTTRPYSQV NVLNFTTSWT DGLAFNAVLH RHKPDLFSWD
200 201
KVVKMSPIER LEHAFSKAQT YLGIEKLLDP EDVAVQLPDK KSIIMYLTSL
250 251
FEVLPQQVTI DAIREVETLP RKYKKECEEE AINIQSTAPE EEHESPRAET
300 301
PSTVTEVDMD LDSYQIALEE VLTWLLSAED TFQEQDDISD DVEEVKDQFA
350 351
THEAFMMELT AHQSSVGSVL QAGNQLITQG TLSDEEEFEI QEQMTLLNAR
400 401
WEALRVESMD RQSRLHDVLM ELQKKQLQQL SAWLTLTEER IQKMETCPLD
450 451
DDVKSLQKLL EEHKSLQSDL EAEQVKVNSL THMVVIVDEN SGESATAILE
500 501
DQLQKLGERW TAVCRWTEER WNRLQEINIL WQELLEEQCL LKAWLTEKEE
550 551
ALNKVQTSNF KDQKELSVSV RRLAILKEDM EMKRQTLDQL SEIGQDVGQL
600 601
LDNSKASKKI NSDSEELTQR WDSLVQRLED SSNQVTQAVA KLGMSQIPQK
650 651
DLLETVRVRE QAITKKSKQE LPPPPPPKKR QIHVDIEAKK KFDAISAELL
700 701
NWILKWKTAI QTTEIKEYMK MQDTSEMKKK LKALEKEQRE RIPRADELNQ
750 751
TGQILVEQMG KEGLPTEEIK NVLEKVSSEW KNVSQHLEDL ERKIQLQEDI
800 801
NAYFKQLDEL EKVIKTKEEW VKHTSISESS RQSLPSLKDS CQRELTNLLG
850 851
LHPKIEMARA SCSALMSQPS APDFVQRGFD SFLGRYQAVQ EAVEDRQQHL
900 901
ENELKGQPGH AYLETLKTLK DVLNDSENKA QVSLNVLNDL AKVEKALQEK
950 951
KTLDEILENQ KPALHKLAEE TKALEKNVHP DVEKLYKQEF DDVQGKWNKL
1000 1001
KVLVSKDLHL LEEIALTLRA FEADSTVIEK WMDGVKDFLM KQQAAQGDDA
1050 1051
GLQRQLDQCS AFVNEIETIE SSLKNMKEIE TNLRSGPVAG IKTWVQTRLG
1100 1101
DYQTQLEKLS KEIATQKSRL SESQEKAANL KKDLAEMQEW MTQAEEEYLE
1150 1151
RDFEYKSPEE LESAVEEMKR AKEDVLQKEV RVKILKDNIK LLAAKVPSGG
1200 1201
QELTSELNVV LENYQLLCNR IRGKCHTLEE VWSCWIELLH YLDLETTWLN
1250 1251
TLEERMKSTE VLPEKTDAVN EALESLESVL RHPADNRTQI RELGQTLIDG
1300 1301
GILDDIISEK LEAFNSRYED LSHLAESKQI SLEKQLQVLR ETDQMLQVLQ
1350 1351
ESLGELDKQL TTYLTDRIDA FQVPQEAQKI QAEISAHELT LEELRRNMRS
1400 1401
QPLTSPESRT ARGGSQMDVL QRKLREVSTK FQLFQKPANF EQRMLDCKRV
1450 1451
LDGVKAELHV LDVKDVDPDV IQTHLDKCMK LYKTLSEVKL EVETVIKTGR
1500 1501
HIVQKQQTDN PKGMDEQLTS LKVLYNDLGA QVTEGKQDLE RASQLARKMK
1550 1551
KEAASLSEWL SATETELVQK STSEGLLGDL DTEISWAKNV LKDLEKRKAD
1600 1601
LNTITESSAA LQNLIEGSEP ILEERLCVLN AGWSRVRTWT EDWCNTLMNH
1650 1651
QNQLEIFDGN VAHISTWLYQ AEALLDEIEK KPTSKQEEIV KRLVSELDDA
1700 1701
NLQVENVRDQ ALILMNARGS SSRELVEPKL AELNRNFEKV SQHIKSAKLL
1750 1751
IAQEPLYQCL VTTETFETGV PFSDLEKLEN DIENMLKFVE KHLESSDEDE
1800 1801
KMDEESAQIE EVLQRGEEML HQPMEDNKKE KIRLQLLLLH TRYNKIKAIP
1850 1851
IQQRKMGQLA SGIRSSLLPT DYLVEINKIL LCMDDVELSL NVPELNTAIY
1900 1901
EDFSFQEDSL KNIKDQLDKL GEQIAVIHEK QPDVILEASG PEAIQIRDTL
1950 1951
TQLNAKWDRI NRMYSDRKGC FDRAMEEWRQ FHCDLNDLTQ WITEAEELLV
2000 2001
DTCAPGGSLD LEKARIHQQE LEVGISSHQP SFAALNRTGD GIVQKLSQAD
2050 2051
GSFLKEKLAG LNQRWDAIVA EVKDRQPRLK GESKQVMKYR HQLDEIICWL
2100 2101
TKAEHAMQKR STTELGENLQ ELRDLTQEME VHAEKLKWLN RTELEMLSDK
2150 2151
SLSLPERDKI SESLRTVNMT WNKICREVPT TLKECIQEPS SVSQTRIAAH
2200 2201
PNVQKVVLVS SASDIPVQSH RTSEISIPAD LDKTITELAD WLVLIDQMLK
2250 2251
SNIVTVGDVE EINKTVSRMK ITKADLEQRH PQLDYVFTLA QNLKNKASSS
2300 2301
DMRTAITEKL ERVKNQWDGT QHGVELRQQQ LEDMIIDSLQ WDDHREETEE
2350 2351
LMRKYEARLY ILQQARRDPL TKQISDNQIL LQELGPGDGI VMAFDNVLQK
2400 2401
LLEEYGSDDT RNVKETTEYL KTSWINLKQS IADRQNALEA EWRTVQASRR
2450 2451
DLENFLKWIQ EAETTVNVLV DASHRENALQ DSILARELKQ QMQDIQAEID
2500 2501
AHNDIFKSID GNRQKMVKAL GNSEEATMLQ HRLDDMNQRW NDLKAKSASI
2550 2551
RAHLEASAEK WNRLLMSLEE LIKWLNMKDE ELKKQMPIGG DVPALQLQYD
2600 2601
HCKALRRELK EKEYSVLNAV DQARVFLADQ PIEAPEEPRR NLQSKTELTP
2650 2651
EERAQKIAKA MRKQSSEVKE KWESLNAVTS NWQKQVDKAL EKLRDLQGAM
2700 2701
DDLDADMKEA ESVRNGWKPV GDLLIDSLQD HIEKIMAFRE EIAPINFKVK
2750 2751
TVNDLSSQLS PLDLHPSLKM SRQLDDLNMR WKLLQVSVDD RLKQLQEAHR
2800 2801
DFGPSSQHFL STSVQLPWQR SISHNKVPYY INHQTQTTCW DHPKMTELFQ
2850 2851
SLADLNNVRF SAYRTAIKIR RLQKALCLDL LELSTTNEIF KQHKLNQNDQ
2900 2901
LLSVPDVINC LTTTYDGLEQ MHKDLVNVPL CVDMCLNWLL NVYDTGRTGK
2950 2951
IRVQSLKIGL MSLSKGLLEE KYRYLFKEVA GPTEMCDQRQ LGLLLHDAIQ
3000 3001
IPRQLGEVAA FGGSNIEPSV RSCFQQNNNK PEISVKEFID WMHLEPQSMV
3050 3051
WLPVLHRVAA AETAKHQAKC NICKECPIVG FRYRSLKHFN YDVCQSCFFS
3100 3101
GRTAKGHKLH YPMVEYCIPT TSGEDVRDFT KVLKNKFRSK KYFAKHPRLG
3150 3151
YLPVQTVLEG DNLETPITLI SMWPEHYDPS QSPQLFHDDT HSRIEQYATR
3200 3201
LAQMERTNGS FLTDSSSTTG SVEDEHALIQ QYCQTLGGES PVSQPQSPAQ
3250 3251
ILKSVEREER GELERIIADL EEEQRNLQVE YEQLKDQHLR RGLPVGSPPE
3300 3301
SIISPHHTSE DSELIAEAKL LRQHKGRLEA RMQILEDHNK QLESQLHRLR
3350 3351
QLLEQPESDS RINGVSPWAS PQHSALSYSL DPDASGPQFH QAAGEDLLAP
3400 3401
PHDTSTDLTE VMEQIHSTFP SCCPNVPSRP QAM
3433
Show the unformatted sequence. |
| Checksums: |
CRC64:C72CADE8CD666993
MD5:b82b3aa61ace43983819af3a8cd1ebb1
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| CH | 150 - 254 | 1BHD | A | 150 - 254 | Show 3D Structure View in InterPro |
| 150 - 256 | 1QAG | A | 150 - 256 | Show 3D Structure View in InterPro | |
| B | 150 - 256 | Show 3D Structure View in InterPro | |||
| 151 - 256 | 1BHD | B | 151 - 256 | Show 3D Structure View in InterPro | |
| 31 - 135 | 6M5G | F | 31 - 135 | Show 3D Structure View in InterPro | |
| G | 31 - 135 | Show 3D Structure View in InterPro | |||
| H | 31 - 135 | Show 3D Structure View in InterPro | |||
| 31 - 136 | 1QAG | A | 31 - 136 | Show 3D Structure View in InterPro | |
| B | 31 - 136 | Show 3D Structure View in InterPro |
×
The parts of the structure corresponding to the Pfam family are highlighted in blue.
Loading Structure Data
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
