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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CBPA2_HUMAN (P48052)

Summary

This is the summary of UniProt entry CBPA2_HUMAN (P48052).

Description: Carboxypeptidase A2 EC=3.4.17.15
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 419 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 18
Pfam Propep_M14 28 102
low_complexity n/a 40 51
Pfam Peptidase_M14 129 406
disorder n/a 262 263
disorder n/a 272 274

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P48052. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAMRLILFFG ALFGHIYCLE TFVGDQVLEI VPSNEEQIKN LLQLEAQEHL
50
51
QLDFWKSPTT PGETAHVRVP FVNVQAVKVF LESQGIAYSI MIEDVQVLLD
100
101
KENEEMLFNR RRERSGNFNF GAYHTLEEIS QEMDNLVAEH PGLVSKVNIG
150
151
SSFENRPMNV LKFSTGGDKP AIWLDAGIHA REWVTQATAL WTANKIVSDY
200
201
GKDPSITSIL DALDIFLLPV TNPDGYVFSQ TKNRMWRKTR SKVSGSLCVG
250
251
VDPNRNWDAG FGGPGASSNP CSDSYHGPSA NSEVEVKSIV DFIKSHGKVK
300
301
AFITLHSYSQ LLMFPYGYKC TKLDDFDELS EVAQKAAQSL RSLHGTKYKV
350
351
GPICSVIYQA SGGSIDWSYD YGIKYSFAFE LRDTGRYGFL LPARQILPTA
400
401
EETWLGLKAI MEHVRDHPY                                  
419
 

Show the unformatted sequence.

Checksums:
CRC64:00269F2AE50CA38D
MD5:343fba5904a195ccff975dff3a7b96a5

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Peptidase_M14 129 - 406 1AYE A 18 - 296 Jmol OpenAstexViewer
1DTD A 374 - 652 Jmol OpenAstexViewer
Propep_M14 28 - 102 1AYE A 13 - 89 Jmol OpenAstexViewer
28 - 96 1O6X A 13 - 81 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.