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9  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NRIP1_HUMAN (P48552)

Summary

This is the summary of UniProt entry NRIP1_HUMAN (P48552).

Description: Nuclear receptor-interacting protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1158 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 6
Pfam NRIP1_repr_1 27 330
disorder n/a 32 56
disorder n/a 64 66
low_complexity n/a 181 197
disorder n/a 189 230
disorder n/a 247 258
disorder n/a 278 341
low_complexity n/a 331 342
disorder n/a 346 369
disorder n/a 382 433
Pfam NRIP1_repr_2 411 738
disorder n/a 435 437
disorder n/a 439 440
disorder n/a 445 467
disorder n/a 471 495
disorder n/a 498 565
low_complexity n/a 547 559
disorder n/a 568 571
disorder n/a 585 627
disorder n/a 630 631
disorder n/a 636 705
low_complexity n/a 705 716
disorder n/a 709 712
disorder n/a 714 751
Pfam NRIP1_repr_3 753 840
disorder n/a 762 789
disorder n/a 792 801
disorder n/a 805 806
disorder n/a 817 818
disorder n/a 824 843
disorder n/a 845 846
Pfam NRIP1_repr_4 848 1158
disorder n/a 864 866
disorder n/a 872 879
disorder n/a 881 882
disorder n/a 888 889
disorder n/a 912 914
disorder n/a 918 924
disorder n/a 951 974
disorder n/a 997 998
disorder n/a 1005 1006
disorder n/a 1013 1021
disorder n/a 1029 1033
disorder n/a 1041 1042
disorder n/a 1044 1051
disorder n/a 1053 1058
disorder n/a 1080 1096
disorder n/a 1100 1107
disorder n/a 1120 1121
disorder n/a 1123 1141

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P48552. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MTHGEELGSD VHQDSIVLTY LEGLLMHQAA GGSGTAVDKK SAGHNEEDQN
50
51
FNISGSAFPT CQSNGPVLNT HTYQGSGMLH LKKARLLQSS EDWNAAKRKR
100
101
LSDSIMNLNV KKEALLAGMV DSVPKGKQDS TLLASLLQSF SSRLQTVALS
150
151
QQIRQSLKEQ GYALSHDSLK VEKDLRCYGV ASSHLKTLLK KSKVKDQKPD
200
201
TNLPDVTKNL IRDRFAESPH HVGQSGTKVM SEPLSCAARL QAVASMVEKR
250
251
ASPATSPKPS VACSQLALLL SSEAHLQQYS REHALKTQNA NQAASERLAA
300
301
MARLQENGQK DVGSYQLPKG MSSHLNGQAR TSSSKLMASK SSATVFQNPM
350
351
GIIPSSPKNA GYKNSLERNN IKQAANNSLL LHLLKSQTIP KPMNGHSHSE
400
401
RGSIFEESST PTTIDEYSDN NPSFTDDSSG DESSYSNCVP IDLSCKHRTE
450
451
KSESDQPVSL DNFTQSLLNT WDPKVPDVDI KEDQDTSKNS KLNSHQKVTL
500
501
LQLLLGHKNE ENVEKNTSPQ GVHNDVSKFN TQNYARTSVI ESPSTNRTTP
550
551
VSTPPLLTSS KAGSPINLSQ HSLVIKWNSP PYVCSTQSEK LTNTASNHSM
600
601
DLTKSKDPPG EKPAQNEGAQ NSATFSASKL LQNLAQCGMQ SSMSVEEQRP
650
651
SKQLLTGNTD KPIGMIDRLN SPLLSNKTNA VEENKAFSSQ PTGPEPGLSG
700
701
SEIENLLERR TVLQLLLGNP NKGKSEKKEK TPLRDESTQE HSERALSEQI
750
751
LMVKIKSEPC DDLQIPNTNV HLSHDAKSAP FLGMAPAVQR SAPALPVSED
800
801
FKSEPVSPQD FSFSKNGLLS RLLRQNQDSY LADDSDRSHR NNEMALLESK
850
851
NLCMVPKKRK LYTEPLENPF KKMKNNIVDA ANNHSAPEVL YGSLLNQEEL
900
901
KFSRNDLEFK YPAGHGSASE SEHRSWARES KSFNVLKQLL LSENCVRDLS
950
951
PHRSNSVADS KKKGHKNNVT NSKPEFSISS LNGLMYSSTQ PSSCMDNRTF
1000
1001
SYPGVVKTPV SPTFPEHLGC AGSRPESGLL NGCSMPSEKG PIKWVITDAE
1050
1051
KNEYEKDSPR LTKTNPILYY MLQKGGNSVT SRETQDKDIW REASSAESVS
1100
1101
QVTAKEELLP TAETKASFFN LRSPYNSHMG NNASRPHSAN GEVYGLLGSV
1150
1151
LTIKKESE                                              
1158
 

Show the unformatted sequence.

Checksums:
CRC64:81FC424968E9A5F6
MD5:0102132689fc3f3faf541cab2e6969b6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
NRIP1_repr_2 498 - 507 6G07 R 498 - 507 Jmol OpenAstexViewer
S 498 - 507 Jmol OpenAstexViewer
498 - 508 6G07 Q 498 - 508 Jmol OpenAstexViewer
499 - 506 5NTI P 499 - 506 Jmol OpenAstexViewer
Q 499 - 506 Jmol OpenAstexViewer
R 499 - 506 Jmol OpenAstexViewer
5NTN P 499 - 506 Jmol OpenAstexViewer
Q 499 - 506 Jmol OpenAstexViewer
R 499 - 506 Jmol OpenAstexViewer
5NU1 P 499 - 506 Jmol OpenAstexViewer
6G05 P 499 - 506 Jmol OpenAstexViewer
Q 499 - 506 Jmol OpenAstexViewer
499 - 507 4S14 C 498 - 506 Jmol OpenAstexViewer
4S15 C 498 - 506 Jmol OpenAstexViewer
D 498 - 506 Jmol OpenAstexViewer
5NTI S 499 - 507 Jmol OpenAstexViewer
5NTN S 499 - 507 Jmol OpenAstexViewer
5NTW P 499 - 507 Jmol OpenAstexViewer
R 499 - 507 Jmol OpenAstexViewer
S 499 - 507 Jmol OpenAstexViewer
5NU1 Q 499 - 507 Jmol OpenAstexViewer
6FZU P 499 - 507 Jmol OpenAstexViewer
Q 499 - 507 Jmol OpenAstexViewer
6G07 P 499 - 507 Jmol OpenAstexViewer
499 - 508 5NTW Q 499 - 508 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.