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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: K2C6C_HUMAN (P48668)

Summary

This is the summary of UniProt entry K2C6C_HUMAN (P48668).

Description: Keratin, type II cytoskeletal 6C
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 564 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 16
low_complexity n/a 3 16
Pfam Keratin_2_head 17 159
disorder n/a 19 21
low_complexity n/a 27 60
low_complexity n/a 63 76
low_complexity n/a 70 85
low_complexity n/a 78 128
Pfam Filament 162 475
coiled_coil n/a 167 187
coiled_coil n/a 232 266
coiled_coil n/a 281 301
disorder n/a 367 369
disorder n/a 371 372
disorder n/a 374 376
coiled_coil n/a 374 454
low_complexity n/a 477 491
low_complexity n/a 493 541
low_complexity n/a 536 547
low_complexity n/a 546 563
disorder n/a 553 557
disorder n/a 560 564

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P48668. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MASTSTTIRS HSSSRRGFSA NSARLPGVSR SGFSSISVSR SRGSGGLGGA
50
51
CGGAGFGSRS LYGLGGSKRI SIGGGSCAIS GGYGSRAGGS YGFGGAGSGF
100
101
GFGGGAGIGF GLGGGAGLAG GFGGPGFPVC PPGGIQEVTV NQSLLTPLNL
150
151
QIDPAIQRVR AEEREQIKTL NNKFASFIDK VRFLEQQNKV LDTKWTLLQE
200
201
QGTKTVRQNL EPLFEQYINN LRRQLDSIVG ERGRLDSELR NMQDLVEDLK
250
251
NKYEDEINKR TAAENEFVTL KKDVDAAYMN KVELQAKADT LTDEINFLRA
300
301
LYDAELSQMQ THISDTSVVL SMDNNRNLDL DSIIAEVKAQ YEEIAQRSRA
350
351
EAESWYQTKY EELQVTAGRH GDDLRNTKQE IAEINRMIQR LRSEIDHVKK
400
401
QCASLQAAIA DAEQRGEMAL KDAKNKLEGL EDALQKAKQD LARLLKEYQE
450
451
LMNVKLALDV EIATYRKLLE GEECRLNGEG VGQVNVSVVQ STISSGYGGA
500
501
SGVGSGLGLG GGSSYSYGSG LGIGGGFSSS SGRAIGGGLS SVGGGSSTIK
550
551
YTTTSSSSRK SYKH                                       
564
 

Show the unformatted sequence.

Checksums:
CRC64:FABEABD829A75612
MD5:30a89d78910fd678cf80d84e8bc8bf9d

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;