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7  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MASP1_HUMAN (P48740)

Summary

This is the summary of UniProt entry MASP1_HUMAN (P48740).

Description: Mannan-binding lectin serine protease 1 EC=3.4.21.-
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 699 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 19
Pfam CUB 20 135
low_complexity n/a 32 43
disorder n/a 101 104
Pfam CUB 185 294
Pfam Sushi 301 362
Pfam Sushi 367 432
Pfam Trypsin 449 691
disorder n/a 534 541
disorder n/a 643 648

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P48740. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRWLLLYYAL CFSLSKASAH TVELNNMFGQ IQSPGYPDSY PSDSEVTWNI
50
51
TVPDGFRIKL YFMHFNLESS YLCEYDYVKV ETEDQVLATF CGRETTDTEQ
100
101
TPGQEVVLSP GSFMSITFRS DFSNEERFTG FDAHYMAVDV DECKEREDEE
150
151
LSCDHYCHNY IGGYYCSCRF GYILHTDNRT CRVECSDNLF TQRTGVITSP
200
201
DFPNPYPKSS ECLYTIELEE GFMVNLQFED IFDIEDHPEV PCPYDYIKIK
250
251
VGPKVLGPFC GEKAPEPIST QSHSVLILFH SDNSGENRGW RLSYRAAGNE
300
301
CPELQPPVHG KIEPSQAKYF FKDQVLVSCD TGYKVLKDNV EMDTFQIECL
350
351
KDGTWSNKIP TCKIVDCRAP GELEHGLITF STRNNLTTYK SEIKYSCQEP
400
401
YYKMLNNNTG IYTCSAQGVW MNKVLGRSLP TCLPVCGLPK FSRKLMARIF
450
451
NGRPAQKGTT PWIAMLSHLN GQPFCGGSLL GSSWIVTAAH CLHQSLDPED
500
501
PTLRDSDLLS PSDFKIILGK HWRLRSDENE QHLGVKHTTL HPQYDPNTFE
550
551
NDVALVELLE SPVLNAFVMP ICLPEGPQQE GAMVIVSGWG KQFLQRFPET
600
601
LMEIEIPIVD HSTCQKAYAP LKKKVTRDMI CAGEKEGGKD ACAGDSGGPM
650
651
VTLNRERGQW YLVGTVSWGD DCGKKDRYGV YSYIHHNKDW IQRVTGVRN 
699
 

Show the unformatted sequence.

Checksums:
CRC64:5B37C7FB9F51FD1D
MD5:954f87b2261e70e226308aa20a9a8342

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
CUB 185 - 294 3DEM A 166 - 275 Jmol OpenAstexViewer
B 166 - 275 Jmol OpenAstexViewer
4AQB A 185 - 294 Jmol OpenAstexViewer
22 - 135 4AQB A 22 - 135 Jmol OpenAstexViewer
26 - 135 3DEM A 7 - 116 Jmol OpenAstexViewer
B 7 - 116 Jmol OpenAstexViewer
Sushi 301 - 362 3GOV A 301 - 362 Jmol OpenAstexViewer
4AQB A 301 - 362 Jmol OpenAstexViewer
4DJZ A 301 - 362 Jmol OpenAstexViewer
C 301 - 362 Jmol OpenAstexViewer
4IGD A 301 - 362 Jmol OpenAstexViewer
4KKD A 301 - 362 Jmol OpenAstexViewer
B 301 - 362 Jmol OpenAstexViewer
367 - 432 3GOV A 367 - 432 Jmol OpenAstexViewer
4DJZ A 367 - 432 Jmol OpenAstexViewer
C 367 - 432 Jmol OpenAstexViewer
4IGD A 367 - 432 Jmol OpenAstexViewer
4KKD A 367 - 432 Jmol OpenAstexViewer
B 367 - 432 Jmol OpenAstexViewer
Trypsin 449 - 691 3GOV B 449 - 691 Jmol OpenAstexViewer
4DJZ B 449 - 691 Jmol OpenAstexViewer
D 449 - 691 Jmol OpenAstexViewer
4IW4 E 431 - 692 Jmol OpenAstexViewer
F 431 - 692 Jmol OpenAstexViewer
4KKD B 450 - 711 Jmol OpenAstexViewer
451 - 691 4IGD A 451 - 691 Jmol OpenAstexViewer
452 - 691 4KKD A 453 - 711 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.