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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: TRPC1_HUMAN (P48995)

Summary

This is the summary of UniProt entry TRPC1_HUMAN (P48995).

Description: Short transient receptor potential channel 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 793 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 15 28
low_complexity n/a 15 28
disorder n/a 30 34
disorder n/a 36 38
disorder n/a 141 142
Pfam TRP_2 193 255
transmembrane n/a 351 371
transmembrane n/a 387 407
Pfam Ion_trans 391 657
low_complexity n/a 398 409
transmembrane n/a 419 437
transmembrane n/a 457 476
transmembrane n/a 496 517
transmembrane n/a 537 559
transmembrane n/a 587 608
transmembrane n/a 620 642
low_complexity n/a 621 643
disorder n/a 754 756

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P48995. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MMAALYPSTD LSGASSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL
50
51
FLLACDKGDY YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENENLDIL
100
101
QLLLDYGCQS ADALLVAIDS EVVGAVDILL NHRPKRSSRP TIVKLMERIQ
150
151
NPEYSTTMDV APVILAAHRN NYEILTMLLK QDVSLPKPHA VGCECTLCSA
200
201
KNKKDSLRHS RFRLDIYRCL ASPALIMLTE EDPILRAFEL SADLKELSLV
250
251
EVEFRNDYEE LARQCKMFAK DLLAQARNSR ELEVILNHTS SDEPLDKRGL
300
301
LEERMNLSRL KLAIKYNQKE FVSQSNCQQF LNTVWFGQMS GYRRKPTCKK
350
351
IMTVLTVGIF WPVLSLCYLI APKSQFGRII HTPFMKFIIH GASYFTFLLL
400
401
LNLYSLVYNE DKKNTMGPAL ERIDYLLILW IIGMIWSDIK RLWYEGLEDF
450
451
LEESRNQLSF VMNSLYLATF ALKVVAHNKF HDFADRKDWD AFHPTLVAEG
500
501
LFAFANVLSY LRLFFMYTTS SILGPLQISM GQMLQDFGKF LGMFLLVLFS
550
551
FTIGLTQLYD KGYTSKEQKD CVGIFCEQQS NDTFHSFIGT CFALFWYIFS
600
601
LAHVAIFVTR FSYGEELQSF VGAVIVGTYN VVVVIVLTKL LVAMLHKSFQ
650
651
LIANHEDKEW KFARAKLWLS YFDDKCTLPP PFNIIPSPKT ICYMISSLSK
700
701
WICSHTSKGK VKRQNSLKEW RNLKQKRDEN YQKVMCCLVH RYLTSMRQKM
750
751
QSTDQATVEN LNELRQDLSK FRNEIRDLLG FRTSKYAMFY PRN       
793
 

Show the unformatted sequence.

Checksums:
CRC64:F4CC57ADDFA320AE
MD5:3179f1d1be72e3c807755e35f4256509

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;