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26  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MAPK2_HUMAN (P49137)

Summary

This is the summary of UniProt entry MAPK2_HUMAN (P49137).

Description: MAP kinase-activated protein kinase 2 EC=2.7.11.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 400 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 47
low_complexity n/a 10 46
Pfam Pkinase 64 325
disorder n/a 336 340
disorder n/a 342 344
disorder n/a 347 348
low_complexity n/a 382 399

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P49137. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MLSNSQGQSP PVPFPAPAPP PQPPTPALPH PPAQPPPPPP QQFPQFHVKS
50
51
GLQIKKNAII DDYKVTSQVL GLGINGKVLQ IFNKRTQEKF ALKMLQDCPK
100
101
ARREVELHWR ASQCPHIVRI VDVYENLYAG RKCLLIVMEC LDGGELFSRI
150
151
QDRGDQAFTE REASEIMKSI GEAIQYLHSI NIAHRDVKPE NLLYTSKRPN
200
201
AILKLTDFGF AKETTSHNSL TTPCYTPYYV APEVLGPEKY DKSCDMWSLG
250
251
VIMYILLCGY PPFYSNHGLA ISPGMKTRIR MGQYEFPNPE WSEVSEEVKM
300
301
LIRNLLKTEP TQRMTITEFM NHPWIMQSTK VPQTPLHTSR VLKEDKERWE
350
351
DVKEEMTSAL ATMRVDYEQI KIKKIEDASN PLLLKRRKKA RALEAAALAH
400
401
                                                      
400
 

Show the unformatted sequence.

Checksums:
CRC64:E4EFFF11CCF288DC
MD5:159c047122396b5e4be8f9058d812929

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 64 - 325 1KWP A 64 - 325 Show 3D Structure View in InterPro
B 64 - 325 Show 3D Structure View in InterPro
1NXK A 64 - 325 Show 3D Structure View in InterPro
B 64 - 325 Show 3D Structure View in InterPro
C 64 - 325 Show 3D Structure View in InterPro
D 64 - 325 Show 3D Structure View in InterPro
1NY3 A 64 - 325 Show 3D Structure View in InterPro
2JBO A 64 - 325 Show 3D Structure View in InterPro
2JBP A 64 - 325 Show 3D Structure View in InterPro
B 64 - 325 Show 3D Structure View in InterPro
C 64 - 325 Show 3D Structure View in InterPro
D 64 - 325 Show 3D Structure View in InterPro
E 64 - 325 Show 3D Structure View in InterPro
F 64 - 325 Show 3D Structure View in InterPro
G 64 - 325 Show 3D Structure View in InterPro
H 64 - 325 Show 3D Structure View in InterPro
I 64 - 325 Show 3D Structure View in InterPro
J 64 - 325 Show 3D Structure View in InterPro
K 64 - 325 Show 3D Structure View in InterPro
L 64 - 325 Show 3D Structure View in InterPro
2ONL C 64 - 325 Show 3D Structure View in InterPro
2OZA A 64 - 325 Show 3D Structure View in InterPro
2P3G X 64 - 325 Show 3D Structure View in InterPro
2PZY A 64 - 325 Show 3D Structure View in InterPro
B 64 - 325 Show 3D Structure View in InterPro
C 64 - 325 Show 3D Structure View in InterPro
D 64 - 325 Show 3D Structure View in InterPro
3A2C A 64 - 325 Show 3D Structure View in InterPro
B 64 - 325 Show 3D Structure View in InterPro
C 64 - 325 Show 3D Structure View in InterPro
D 64 - 325 Show 3D Structure View in InterPro
E 64 - 325 Show 3D Structure View in InterPro
F 64 - 325 Show 3D Structure View in InterPro
G 64 - 325 Show 3D Structure View in InterPro
H 64 - 325 Show 3D Structure View in InterPro
I 64 - 325 Show 3D Structure View in InterPro
J 64 - 325 Show 3D Structure View in InterPro
K 64 - 325 Show 3D Structure View in InterPro
L 64 - 325 Show 3D Structure View in InterPro
3FPM A 64 - 325 Show 3D Structure View in InterPro
3FYJ X 64 - 325 Show 3D Structure View in InterPro
3FYK X 64 - 325 Show 3D Structure View in InterPro
3GOK A 64 - 325 Show 3D Structure View in InterPro
B 64 - 325 Show 3D Structure View in InterPro
C 64 - 325 Show 3D Structure View in InterPro
D 64 - 325 Show 3D Structure View in InterPro
E 64 - 325 Show 3D Structure View in InterPro
F 64 - 325 Show 3D Structure View in InterPro
G 64 - 325 Show 3D Structure View in InterPro
H 64 - 325 Show 3D Structure View in InterPro
I 64 - 325 Show 3D Structure View in InterPro
J 64 - 325 Show 3D Structure View in InterPro
K 64 - 325 Show 3D Structure View in InterPro
L 64 - 325 Show 3D Structure View in InterPro
3KA0 A 64 - 325 Show 3D Structure View in InterPro
3KC3 A 64 - 325 Show 3D Structure View in InterPro
B 64 - 325 Show 3D Structure View in InterPro
C 64 - 325 Show 3D Structure View in InterPro
D 64 - 325 Show 3D Structure View in InterPro
E 64 - 325 Show 3D Structure View in InterPro
F 64 - 325 Show 3D Structure View in InterPro
G 64 - 325 Show 3D Structure View in InterPro
H 64 - 325 Show 3D Structure View in InterPro
I 64 - 325 Show 3D Structure View in InterPro
J 64 - 325 Show 3D Structure View in InterPro
K 64 - 325 Show 3D Structure View in InterPro
L 64 - 325 Show 3D Structure View in InterPro
3KGA A 64 - 325 Show 3D Structure View in InterPro
3M2W A 64 - 325 Show 3D Structure View in InterPro
3M42 A 64 - 325 Show 3D Structure View in InterPro
3R2B A 64 - 325 Show 3D Structure View in InterPro
B 64 - 325 Show 3D Structure View in InterPro
C 64 - 325 Show 3D Structure View in InterPro
D 64 - 325 Show 3D Structure View in InterPro
E 64 - 325 Show 3D Structure View in InterPro
F 64 - 325 Show 3D Structure View in InterPro
G 64 - 325 Show 3D Structure View in InterPro
H 64 - 325 Show 3D Structure View in InterPro
I 64 - 325 Show 3D Structure View in InterPro
J 64 - 325 Show 3D Structure View in InterPro
K 64 - 325 Show 3D Structure View in InterPro
L 64 - 325 Show 3D Structure View in InterPro
3R2Y A 64 - 325 Show 3D Structure View in InterPro
3R30 A 64 - 325 Show 3D Structure View in InterPro
3WI6 A 64 - 325 Show 3D Structure View in InterPro
B 64 - 325 Show 3D Structure View in InterPro
C 64 - 325 Show 3D Structure View in InterPro
D 64 - 325 Show 3D Structure View in InterPro
E 64 - 325 Show 3D Structure View in InterPro
F 64 - 325 Show 3D Structure View in InterPro
4TYH A 64 - 325 Show 3D Structure View in InterPro
6T8X A 64 - 325 Show 3D Structure View in InterPro
B 64 - 325 Show 3D Structure View in InterPro
C 64 - 325 Show 3D Structure View in InterPro
D 64 - 325 Show 3D Structure View in InterPro
E 64 - 325 Show 3D Structure View in InterPro
F 64 - 325 Show 3D Structure View in InterPro
6TCA A 64 - 325 Show 3D Structure View in InterPro
C 64 - 325 Show 3D Structure View in InterPro
E 64 - 325 Show 3D Structure View in InterPro
G 64 - 325 Show 3D Structure View in InterPro
78 - 325 2ONL D 78 - 325 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;