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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: AL9A1_HUMAN (P49189)

Summary

This is the summary of UniProt entry AL9A1_HUMAN (P49189).

Description: 4-trimethylaminobutyraldehyde dehydrogenase
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 494 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 19 20
Pfam Aldedh 21 483
disorder n/a 25 27
low_complexity n/a 74 91

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P49189. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSTGTFVVSQ PLNYRGGARV EPADASGTEK AFEPATGRVI ATFTCSGEKE
50
51
VNLAVQNAKA AFKIWSQKSG MERCRILLEA ARIIREREDE IATMECINNG
100
101
KSIFEARLDI DISWQCLEYY AGLAASMAGE HIQLPGGSFG YTRREPLGVC
150
151
VGIGAWNYPF QIASWKSAPA LACGNAMVFK PSPFTPVSAL LLAEIYSEAG
200
201
VPPGLFNVVQ GGAATGQFLC QHPDVAKVSF TGSVPTGMKI MEMSAKGIKP
250
251
VTLELGGKSP LIIFSDCDMN NAVKGALMAN FLTQGQVCCN GTRVFVQKEI
300
301
LDKFTEEVVK QTQRIKIGDP LLEDTRMGPL INRPHLERVL GFVKVAKEQG
350
351
AKVLCGGDIY VPEDPKLKDG YYMRPCVLTN CRDDMTCVKE EIFGPVMSIL
400
401
SFDTEAEVLE RANDTTFGLA AGVFTRDIQR AHRVVAELQA GTCFINNYNV
450
451
SPVELPFGGY KKSGFGRENG RVTIEYYSQL KTVCVEMGDV ESAF      
494
 

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Checksums:
CRC64:1E1CDF910D763BA1
MD5:2fbbc5f4762320a581c19b11f02a20a6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Aldedh 21 - 483 6QAK A 21 - 483 Jmol OpenAstexViewer
B 21 - 483 Jmol OpenAstexViewer
C 21 - 483 Jmol OpenAstexViewer
D 21 - 483 Jmol OpenAstexViewer
E 21 - 483 Jmol OpenAstexViewer
F 21 - 483 Jmol OpenAstexViewer
G 21 - 483 Jmol OpenAstexViewer
H 21 - 483 Jmol OpenAstexViewer
6QAO A 21 - 483 Jmol OpenAstexViewer
B 21 - 483 Jmol OpenAstexViewer
C 21 - 483 Jmol OpenAstexViewer
D 21 - 483 Jmol OpenAstexViewer
E 21 - 483 Jmol OpenAstexViewer
F 21 - 483 Jmol OpenAstexViewer
G 21 - 483 Jmol OpenAstexViewer
H 21 - 483 Jmol OpenAstexViewer
6QAP A 21 - 483 Jmol OpenAstexViewer
B 21 - 483 Jmol OpenAstexViewer
C 21 - 483 Jmol OpenAstexViewer
D 21 - 483 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.