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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: DHE4_HUMAN (P49448)

Summary

This is the summary of UniProt entry DHE4_HUMAN (P49448).

Description: Glutamate dehydrogenase 2, mitochondrial EC=1.4.1.3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 558 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
low_complexity n/a 17 31
disorder n/a 30 34
low_complexity n/a 35 49
disorder n/a 89 94
disorder n/a 96 97
Pfam ELFV_dehydrog_N 112 242
disorder n/a 133 134
disorder n/a 143 144
disorder n/a 148 149
disorder n/a 221 223
Pfam ELFV_dehydrog 263 463
disorder n/a 399 404

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P49448. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MYRYLAKALL PSRAGPAALG SAANHSAALL GRGRGQPAAA SQPGLALAAR
50
51
RHYSELVADR EDDPNFFKMV EGFFDRGASI VEDKLVKDLR TQESEEQKRN
100
101
RVRGILRIIK PCNHVLSLSF PIRRDDGSWE VIEGYRAQHS QHRTPCKGGI
150
151
RYSTDVSVDE VKALASLMTY KCAVVDVPFG GAKAGVKINP KNYTENELEK
200
201
ITRRFTMELA KKGFIGPGVD VPAPDMNTGE REMSWIADTY ASTIGHYDIN
250
251
AHACVTGKPI SQGGIHGRIS ATGRGVFHGI ENFINEASYM SILGMTPGFR
300
301
DKTFVVQGFG NVGLHSMRYL HRFGAKCIAV GESDGSIWNP DGIDPKELED
350
351
FKLQHGSILG FPKAKPYEGS ILEVDCDILI PAATEKQLTK SNAPRVKAKI
400
401
IAEGANGPTT PEADKIFLER NILVIPDLYL NAGGVTVSYF EWLKNLNHVS
450
451
YGRLTFKYER DSNYHLLLSV QESLERKFGK HGGTIPIVPT AEFQDSISGA
500
501
SEKDIVHSAL AYTMERSARQ IMHTAMKYNL GLDLRTAAYV NAIEKVFKVY
550
551
SEAGVTFT                                              
558
 

Show the unformatted sequence.

Checksums:
CRC64:F222B1B2CB74A6EA
MD5:38f411982166a70abf777062d750ad4c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
ELFV_dehydrog 263 - 463 6G2U A 210 - 410 Show 3D Structure View in InterPro
B 210 - 410 Show 3D Structure View in InterPro
C 210 - 410 Show 3D Structure View in InterPro
D 210 - 410 Show 3D Structure View in InterPro
E 210 - 410 Show 3D Structure View in InterPro
F 210 - 410 Show 3D Structure View in InterPro
ELFV_dehydrog_N 112 - 242 6G2U A 59 - 189 Show 3D Structure View in InterPro
B 59 - 189 Show 3D Structure View in InterPro
C 59 - 189 Show 3D Structure View in InterPro
D 59 - 189 Show 3D Structure View in InterPro
E 59 - 189 Show 3D Structure View in InterPro
F 59 - 189 Show 3D Structure View in InterPro
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The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;