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0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MA2A2_HUMAN (P49641)

Summary

This is the summary of UniProt entry MA2A2_HUMAN (P49641).

Description: Alpha-mannosidase 2x
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1150 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
transmembrane n/a 7 26
disorder n/a 34 42
coiled_coil n/a 47 67
low_complexity n/a 50 68
Pfam Glyco_hydro_38N 167 497
Pfam Alpha-mann_mid 502 606
low_complexity n/a 713 726
Pfam Glyco_hydro_38C 765 970
disorder n/a 970 976

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P49641. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MKLKKQVTVC GAAIFCVAVF SLYLMLDRVQ HDPTRHQNGG NFPRSQISVL
50
51
QNRIEQLEQL LEENHEIISH IKDSVLELTA NAEGPPAMLP YYTVNGSWVV
100
101
PPEPRPSFFS ISPQDCQFAL GGRGQKPELQ MLTVSEELPF DNVDGGVWRQ
150
151
GFDISYDPHD WDAEDLQVFV VPHSHNDPGW IKTFDKYYTE QTQHILNSMV
200
201
SKLQEDPRRR FLWAEVSFFA KWWDNINVQK RAAVRRLVGN GQLEIATGGW
250
251
VMPDEANSHY FALIDQLIEG HQWLERNLGA TPRSGWAVDP FGYSSTMPYL
300
301
LRRANLTSML IQRVHYAIKK HFAATHSLEF MWRQTWDSDS STDIFCHMMP
350
351
FYSYDVPHTC GPDPKICCQF DFKRLPGGRI NCPWKVPPRA ITEANVAERA
400
401
ALLLDQYRKK SQLFRSNVLL VPLGDDFRYD KPQEWDAQFF NYQRLFDFFN
450
451
SRPNLHVQAQ FGTLSDYFDA LYKRTGVEPG ARPPGFPVLS GDFFSYADRE
500
501
DHYWTGYYTS RPFYKSLDRV LEAHLRGAEV LYSLAAAHAR RSGLAGRYPL
550
551
SDFTLLTEAR RTLGLFQHHD AITGTAKEAV VVDYGVRLLR SLVNLKQVII
600
601
HAAHYLVLGD KETYHFDPEA PFLQVDDTRL SHDALPERTV IQLDSSPRFV
650
651
VLFNPLEQER FSMVSLLVNS PRVRVLSEEG QPLAVQISAH WSSATEAVPD
700
701
VYQVSVPVRL PALGLGVLQL QLGLDGHRTL PSSVRIYLHG RQLSVSRHEA
750
751
FPLRVIDSGT SDFALSNRYM QVWFSGLTGL LKSIRRVDEE HEQQVDMQVL
800
801
VYGTRTSKDK SGAYLFLPDG EAKPYVPKEP PVLRVTEGPF FSEVVAYYEH
850
851
IHQAVRLYNL PGVEGLSLDI SSLVDIRDYV NKELALHIHT DIDSQGIFFT
900
901
DLNGFQVQPR RYLKKLPLQA NFYPMPVMAY IQDAQKRLTL HTAQALGVSS
950
951
LKDGQLEVIL DRRLMQDDNR GLGQGLKDNK RTCNRFRLLL ERRTVGSEVQ
1000
1001
DSHSTSYPSL LSHLTSMYLN APALALPVAR MQLPGPGLRS FHPLASSLPC
1050
1051
DFHLLNLRTL QAEEDTLPSA ETALILHRKG FDCGLEAKNL GFNCTTSQGK
1100
1101
VALGSLFHGL DVVFLQPTSL TLLYPLASPS NSTDVYLEPM EIATFRLRLG
1150
1151
                                                      
1150
 

Show the unformatted sequence.

Checksums:
CRC64:BFB3D763A6A55444
MD5:f8fe3a1ac6e91e89f4844f7caac82563

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;