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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MCM2_HUMAN (P49736)

Summary

This is the summary of UniProt entry MCM2_HUMAN (P49736).

Description: DNA replication licensing factor MCM2 EC=3.6.4.12
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 904 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 125
Pfam MCM2_N 51 182
low_complexity n/a 51 77
low_complexity n/a 106 123
low_complexity n/a 124 135
disorder n/a 127 173
coiled_coil n/a 154 174
low_complexity n/a 154 175
Pfam MCM_N 196 291
Pfam MCM_OB 293 422
Pfam MCM 460 683
disorder n/a 596 604
disorder n/a 682 683
disorder n/a 687 703
disorder n/a 706 708
Pfam MCM_lid 718 802

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P49736. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAESSESFTM ASSPAQRRRG NDPLTSSPGR SSRRTDALTS SPGRDLPPFE
50
51
DESEGLLGTE GPLEEEEDGE ELIGDGMERD YRAIPELDAY EAEGLALDDE
100
101
DVEELTASQR EAAERAMRQR DREAGRGLGR MRRGLLYDSD EEDEERPARK
150
151
RRQVERATED GEEDEEMIES IENLEDLKGH SVREWVSMAG PRLEIHHRFK
200
201
NFLRTHVDSH GHNVFKERIS DMCKENRESL VVNYEDLAAR EHVLAYFLPE
250
251
APAELLQIFD EAALEVVLAM YPKYDRITNH IHVRISHLPL VEELRSLRQL
300
301
HLNQLIRTSG VVTSCTGVLP QLSMVKYNCN KCNFVLGPFC QSQNQEVKPG
350
351
SCPECQSAGP FEVNMEETIY QNYQRIRIQE SPGKVAAGRL PRSKDAILLA
400
401
DLVDSCKPGD EIELTGIYHN NYDGSLNTAN GFPVFATVIL ANHVAKKDNK
450
451
VAVGELTDED VKMITSLSKD QQIGEKIFAS IAPSIYGHED IKRGLALALF
500
501
GGEPKNPGGK HKVRGDINVL LCGDPGTAKS QFLKYIEKVS SRAIFTTGQG
550
551
ASAVGLTAYV QRHPVSREWT LEAGALVLAD RGVCLIDEFD KMNDQDRTSI
600
601
HEAMEQQSIS ISKAGIVTSL QARCTVIAAA NPIGGRYDPS LTFSENVDLT
650
651
EPIISRFDIL CVVRDTVDPV QDEMLARFVV GSHVRHHPSN KEEEGLANGS
700
701
AAEPAMPNTY GVEPLPQEVL KKYIIYAKER VHPKLNQMDQ DKVAKMYSDL
750
751
RKESMATGSI PITVRHIESM IRMAEAHARI HLRDYVIEDD VNMAIRVMLE
800
801
SFIDTQKFSV MRSMRKTFAR YLSFRRDNNE LLLFILKQLV AEQVTYQRNR
850
851
FGAQQDTIEV PEKDLVDKAR QINIHNLSAF YDSELFRMNK FSHDLKRKMI
900
901
LQQF                                                  
904
 

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Checksums:
CRC64:52C6DC61F128B404
MD5:bb5d90539c536b36b294e50bddd8a7b9

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
MCM2_N 68 - 123 5C3I D 68 - 123 Jmol OpenAstexViewer
H 68 - 123 Jmol OpenAstexViewer
L 68 - 123 Jmol OpenAstexViewer
X 68 - 123 Jmol OpenAstexViewer
68 - 124 5BNV C 68 - 124 Jmol OpenAstexViewer
5BNX C 68 - 124 Jmol OpenAstexViewer
5BO0 C 68 - 124 Jmol OpenAstexViewer
5JA4 C 68 - 124 Jmol OpenAstexViewer
68 - 125 5BNV F 68 - 125 Jmol OpenAstexViewer
69 - 116 5C3I P 69 - 116 Jmol OpenAstexViewer
69 - 122 4UUZ C 69 - 122 Jmol OpenAstexViewer
69 - 124 5C3I T 69 - 124 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.