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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: EI2BB_HUMAN (P49770)

Summary

This is the summary of UniProt entry EI2BB_HUMAN (P49770).

Description: Translation initiation factor eIF-2B subunit beta
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 351 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 12
disorder n/a 15 34
Pfam IF-2B 27 333
disorder n/a 37 38
disorder n/a 62 76
disorder n/a 99 101
disorder n/a 104 110
coiled_coil n/a 134 154

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P49770. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPGSAAKGSE LSERIESFVE TLKRGGGPRS SEEMARETLG LLRQIITDHR
50
51
WSNAGELMEL IRREGRRMTA AQPSETTVGN MVRRVLKIIR EEYGRLHGRS
100
101
DESDQQESLH KLLTSGGLNE DFSFHYAQLQ SNIIEAINEL LVELEGTMEN
150
151
IAAQALEHIH SNEVIMTIGF SRTVEAFLKE AARKRKFHVI VAECAPFCQG
200
201
HEMAVNLSKA GIETTVMTDA AIFAVMSRVN KVIIGTKTIL ANGALRAVTG
250
251
THTLALAAKH HSTPLIVCAP MFKLSPQFPN EEDSFHKFVA PEEVLPFTEG
300
301
DILEKVSVHC PVFDYVPPEL ITLFISNIGG NAPSYIYRLM SELYHPDDHV
350
351
L                                                     
351
 

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Checksums:
CRC64:C29FE477143F545A
MD5:79573d6a292c7e48b71593b34accf870

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
IF-2B 27 - 333 6CAJ C 27 - 333 Jmol OpenAstexViewer
D 27 - 333 Jmol OpenAstexViewer
6EZO C 27 - 333 Jmol OpenAstexViewer
D 27 - 333 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.