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43  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: 5NTC_HUMAN (P49902)

Summary

This is the summary of UniProt entry 5NTC_HUMAN (P49902).

Description: Cytosolic purine 5'-nucleotidase EC=3.1.3.5
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 561 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam 5_nucleotid 35 489
disorder n/a 491 502
disorder n/a 506 509
disorder n/a 511 512
disorder n/a 539 561
low_complexity n/a 548 560

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P49902. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSTSWSDRLQ NAADMPANMD KHALKKYRRE AYHRVFVNRS LAMEKIKCFG
50
51
FDMDYTLAVY KSPEYESLGF ELTVERLVSI GYPQELLSFA YDSTFPTRGL
100
101
VFDTLYGNLL KVDAYGNLLV CAHGFNFIRG PETREQYPNK FIQRDDTERF
150
151
YILNTLFNLP ETYLLACLVD FFTNCPRYTS CETGFKDGDL FMSYRSMFQD
200
201
VRDAVDWVHY KGSLKEKTVE NLEKYVVKDG KLPLLLSRMK EVGKVFLATN
250
251
SDYKYTDKIM TYLFDFPHGP KPGSSHRPWQ SYFDLILVDA RKPLFFGEGT
300
301
VLRQVDTKTG KLKIGTYTGP LQHGIVYSGG SSDTICDLLG AKGKDILYIG
350
351
DHIFGDILKS KKRQGWRTFL VIPELAQELH VWTDKSSLFE ELQSLDIFLA
400
401
ELYKHLDSSS NERPDISSIQ RRIKKVTHDM DMCYGMMGSL FRSGSRQTLF
450
451
ASQVMRYADL YAASFINLLY YPFSYLFRAA HVLMPHESTV EHTHVDINEM
500
501
ESPLATRNRT SVDFKDTDYK RHQLTRSISE IKPPNLFPLA PQEITHCHDE
550
551
DDDEEEEEEE E                                          
561
 

Show the unformatted sequence.

Checksums:
CRC64:4C27D762575E0EA2
MD5:d55f1b18f1a031a7a26d1f13f85e31fc

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
5_nucleotid 35 - 488 2J2C A 35 - 488 Jmol OpenAstexViewer
2JC9 A 35 - 488 Jmol OpenAstexViewer
2JCM A 35 - 488 Jmol OpenAstexViewer
2XCV A 35 - 488 Jmol OpenAstexViewer
2XCW A 35 - 488 Jmol OpenAstexViewer
2XCX A 35 - 488 Jmol OpenAstexViewer
2XJB A 35 - 488 Jmol OpenAstexViewer
2XJC A 35 - 488 Jmol OpenAstexViewer
2XJD A 35 - 488 Jmol OpenAstexViewer
2XJE A 35 - 488 Jmol OpenAstexViewer
2XJF A 35 - 488 Jmol OpenAstexViewer
4H4B A 35 - 488 Jmol OpenAstexViewer
5K7Y A 35 - 488 Jmol OpenAstexViewer
5L4Z A 35 - 488 Jmol OpenAstexViewer
5L50 A 35 - 488 Jmol OpenAstexViewer
5OPK A 35 - 488 Jmol OpenAstexViewer
5OPL A 35 - 488 Jmol OpenAstexViewer
5OPM A 35 - 488 Jmol OpenAstexViewer
5OPN A 35 - 488 Jmol OpenAstexViewer
5OPO A 35 - 488 Jmol OpenAstexViewer
5OPP A 35 - 488 Jmol OpenAstexViewer
6DD3 A 35 - 488 Jmol OpenAstexViewer
6DDH A 35 - 488 Jmol OpenAstexViewer
6DDX A 35 - 488 Jmol OpenAstexViewer
6DDY A 35 - 488 Jmol OpenAstexViewer
6DDZ A 35 - 488 Jmol OpenAstexViewer
6DE0 A 35 - 488 Jmol OpenAstexViewer
6DE1 A 35 - 488 Jmol OpenAstexViewer
6DE2 A 35 - 488 Jmol OpenAstexViewer
6DE3 A 35 - 488 Jmol OpenAstexViewer
6FIS A 35 - 488 Jmol OpenAstexViewer
6FIU A 35 - 488 Jmol OpenAstexViewer
6FIW A 35 - 488 Jmol OpenAstexViewer
35 - 489 5CQZ A 35 - 489 Jmol OpenAstexViewer
B 35 - 489 Jmol OpenAstexViewer
5CR7 A 35 - 489 Jmol OpenAstexViewer
B 35 - 489 Jmol OpenAstexViewer
6DDB A 35 - 489 Jmol OpenAstexViewer
B 35 - 489 Jmol OpenAstexViewer
6DDC A 35 - 489 Jmol OpenAstexViewer
B 35 - 489 Jmol OpenAstexViewer
6DDK A 35 - 489 Jmol OpenAstexViewer
B 35 - 489 Jmol OpenAstexViewer
6DDL A 35 - 489 Jmol OpenAstexViewer
B 35 - 489 Jmol OpenAstexViewer
6DDO A 35 - 489 Jmol OpenAstexViewer
B 35 - 489 Jmol OpenAstexViewer
6DDQ A 35 - 489 Jmol OpenAstexViewer
B 35 - 489 Jmol OpenAstexViewer
6FIR A 35 - 489 Jmol OpenAstexViewer
6FXH A 35 - 489 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.