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8  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: DNLI3_HUMAN (P49916)

Summary

This is the summary of UniProt entry DNLI3_HUMAN (P49916).

Description: DNA ligase 3
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1009 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
Pfam zf-PARP 96 181
low_complexity n/a 158 175
disorder n/a 163 165
disorder n/a 168 169
disorder n/a 171 172
disorder n/a 174 186
disorder n/a 188 189
disorder n/a 193 205
disorder n/a 212 214
disorder n/a 226 253
low_complexity n/a 240 252
Pfam DNA_ligase_A_N 262 434
coiled_coil n/a 444 464
disorder n/a 455 456
disorder n/a 458 459
disorder n/a 461 463
disorder n/a 465 469
disorder n/a 472 473
Pfam DNA_ligase_A_M 483 677
Pfam DNA_ligase_A_C 704 814
disorder n/a 815 816
disorder n/a 840 917
low_complexity n/a 845 856
low_complexity n/a 863 880
disorder n/a 919 922
Pfam LIG3_BRCT 933 1003
disorder n/a 978 979
disorder n/a 981 984

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P49916. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSLAFKIFFP QTLRALSRKE LCLFRKHHWR DVRQFSQWSE TDLLHGHPLF
50
51
LRRKPVLSFQ GSHLRSRATY LVFLPGLHVG LCSGPCEMAE QRFCVDYAKR
100
101
GTAGCKKCKE KIVKGVCRIG KVVPNPFSES GGDMKEWYHI KCMFEKLERA
150
151
RATTKKIEDL TELEGWEELE DNEKEQITQH IADLSSKAAG TPKKKAVVQA
200
201
KLTTTGQVTS PVKGASFVTS TNPRKFSGFS AKPNNSGEAP SSPTPKRSLS
250
251
SSKCDPRHKD CLLREFRKLC AMVADNPSYN TKTQIIQDFL RKGSAGDGFH
300
301
GDVYLTVKLL LPGVIKTVYN LNDKQIVKLF SRIFNCNPDD MARDLEQGDV
350
351
SETIRVFFEQ SKSFPPAAKS LLTIQEVDEF LLRLSKLTKE DEQQQALQDI
400
401
ASRCTANDLK CIIRLIKHDL KMNSGAKHVL DALDPNAYEA FKASRNLQDV
450
451
VERVLHNAQE VEKEPGQRRA LSVQASLMTP VQPMLAEACK SVEYAMKKCP
500
501
NGMFSEIKYD GERVQVHKNG DHFSYFSRSL KPVLPHKVAH FKDYIPQAFP
550
551
GGHSMILDSE VLLIDNKTGK PLPFGTLGVH KKAAFQDANV CLFVFDCIYF
600
601
NDVSLMDRPL CERRKFLHDN MVEIPNRIMF SEMKRVTKAL DLADMITRVI
650
651
QEGLEGLVLK DVKGTYEPGK RHWLKVKKDY LNEGAMADTA DLVVLGAFYG
700
701
QGSKGGMMSI FLMGCYDPGS QKWCTVTKCA GGHDDATLAR LQNELDMVKI
750
751
SKDPSKIPSW LKVNKIYYPD FIVPDPKKAA VWEITGAEFS KSEAHTADGI
800
801
SIRFPRCTRI RDDKDWKSAT NLPQLKELYQ LSKEKADFTV VAGDEGSSTT
850
851
GGSSEENKGP SGSAVSRKAP SKPSASTKKA EGKLSNSNSK DGNMQTAKPS
900
901
AMKVGEKLAT KSSPVKVGEK RKAADETLCQ TKVLLDIFTG VRLYLPPSTP
950
951
DFSRLRRYFV AFDGDLVQEF DMTSATHVLG SRDKNPAAQQ VSPEWIWACI
1000
1001
RKRRLVAPC                                             
1009
 

Show the unformatted sequence.

Checksums:
CRC64:0E4057E33C3F19A6
MD5:0f75165da923ab4589cf0522a87180d8

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DNA_ligase_A_C 704 - 814 3L2P A 617 - 727 Show 3D Structure View in InterPro
DNA_ligase_A_M 483 - 677 3L2P A 396 - 590 Show 3D Structure View in InterPro
DNA_ligase_A_N 262 - 434 3L2P A 175 - 347 Show 3D Structure View in InterPro
LIG3_BRCT 933 - 1003 1IMO A 846 - 916 Show 3D Structure View in InterPro
1IN1 A 846 - 916 Show 3D Structure View in InterPro
3PC7 A 846 - 916 Show 3D Structure View in InterPro
B 846 - 916 Show 3D Structure View in InterPro
3PC8 C 846 - 916 Show 3D Structure View in InterPro
D 846 - 916 Show 3D Structure View in InterPro
3QVG A 846 - 916 Show 3D Structure View in InterPro
C 846 - 916 Show 3D Structure View in InterPro
6WH1 B 846 - 916 Show 3D Structure View in InterPro
zf-PARP 96 - 181 1UW0 A 9 - 94 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;