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10  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: MMP14_HUMAN (P50281)

Summary

This is the summary of UniProt entry MMP14_HUMAN (P50281).

Description: Matrix metalloproteinase-14 EC=3.4.24.80
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 582 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 28
low_complexity n/a 1 34
Pfam PG_binding_1 36 88
disorder n/a 49 51
disorder n/a 55 56
disorder n/a 85 87
Pfam Peptidase_M10 118 284
disorder n/a 215 222
disorder n/a 281 316
Pfam Hemopexin 323 366
Pfam Hemopexin 368 412
low_complexity n/a 374 385
Pfam Hemopexin 415 461
Pfam Hemopexin 465 510
disorder n/a 508 514
Pfam DUF3377 512 582
low_complexity n/a 514 534
disorder n/a 521 524
low_complexity n/a 532 558
transmembrane n/a 539 562

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P50281. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSPAPRPPRC LLLPLLTLGT ALASLGSAQS SSFSPEAWLQ QYGYLPPGDL
50
51
RTHTQRSPQS LSAAIAAMQK FYGLQVTGKA DADTMKAMRR PRCGVPDKFG
100
101
AEIKANVRRK RYAIQGLKWQ HNEITFCIQN YTPKVGEYAT YEAIRKAFRV
150
151
WESATPLRFR EVPYAYIREG HEKQADIMIF FAEGFHGDST PFDGEGGFLA
200
201
HAYFPGPNIG GDTHFDSAEP WTVRNEDLNG NDIFLVAVHE LGHALGLEHS
250
251
SDPSAIMAPF YQWMDTENFV LPDDDRRGIQ QLYGGESGFP TKMPPQPRTT
300
301
SRPSVPDKPK NPTYGPNICD GNFDTVAMLR GEMFVFKERW FWRVRNNQVM
350
351
DGYPMPIGQF WRGLPASINT AYERKDGKFV FFKGDKHWVF DEASLEPGYP
400
401
KHIKELGRGL PTDKIDAALF WMPNGKTYFF RGNKYYRFNE ELRAVDSEYP
450
451
KNIKVWEGIP ESPRGSFMGS DEVFTYFYKG NKYWKFNNQK LKVEPGYPKS
500
501
ALRDWMGCPS GGRPDEGTEE ETEVIIIEVD EEGGGAVSAA AVVLPVLLLL
550
551
LVLAVGLAVF FFRRHGTPRR LLYCQRSLLD KV                   
582
 

Show the unformatted sequence.

Checksums:
CRC64:3722DE286A4BBCDE
MD5:4d7824ddaaa164b7e53fa388b6e606d9

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
DUF3377 566 - 576 3X23 B 566 - 576 Jmol OpenAstexViewer
Hemopexin 323 - 366 2MQS A 323 - 366 Jmol OpenAstexViewer
3C7X A 323 - 366 Jmol OpenAstexViewer
368 - 412 2MQS A 368 - 412 Jmol OpenAstexViewer
3C7X A 368 - 412 Jmol OpenAstexViewer
415 - 461 2MQS A 415 - 461 Jmol OpenAstexViewer
3C7X A 415 - 461 Jmol OpenAstexViewer
465 - 510 2MQS A 465 - 510 Jmol OpenAstexViewer
3C7X A 465 - 510 Jmol OpenAstexViewer
Peptidase_M10 118 - 284 1BQQ M 118 - 284 Jmol OpenAstexViewer
1BUV M 118 - 284 Jmol OpenAstexViewer
3MA2 A 118 - 284 Jmol OpenAstexViewer
D 118 - 284 Jmol OpenAstexViewer
5H0U A 118 - 284 Jmol OpenAstexViewer
215 - 227 4P3C M 215 - 227 Jmol OpenAstexViewer
4P3D C 215 - 227 Jmol OpenAstexViewer
M 215 - 227 Jmol OpenAstexViewer
218 - 228 4QXU K 218 - 228 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.