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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: FXR1_HUMAN (P51114)

Summary

This is the summary of UniProt entry FXR1_HUMAN (P51114).

Description: Fragile X mental retardation syndrome-related protein 1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 621 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam Tudor_FRX1 4 52
disorder n/a 42 45
disorder n/a 47 48
disorder n/a 55 56
disorder n/a 60 61
Pfam Agenet 62 117
Pfam KH_9 123 207
Pfam KH_1 220 280
Pfam KH_1 283 353
disorder n/a 319 321
Pfam FXMRP1_C_core 354 380
disorder n/a 375 621
low_complexity n/a 378 391
Pfam FXMRP1_C_core 379 456
low_complexity n/a 427 466
Pfam FXR_C1 460 535
low_complexity n/a 501 509
Pfam FXR_C3 554 620

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P51114. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAELTVEVRG SNGAFYKGFI KDVHEDSLTV VFENNWQPER QVPFNEVRLP
50
51
PPPDIKKEIS EGDEVEVYSR ANDQEPCGWW LAKVRMMKGE FYVIEYAACD
100
101
ATYNEIVTFE RLRPVNQNKT VKKNTFFKCT VDVPEDLREA CANENAHKDF
150
151
KKAVGACRIF YHPETTQLMI LSASEATVKR VNILSDMHLR SIRTKLMLMS
200
201
RNEEATKHLE CTKQLAAAFH EEFVVREDLM GLAIGTHGSN IQQARKVPGV
250
251
TAIELDEDTG TFRIYGESAD AVKKARGFLE FVEDFIQVPR NLVGKVIGKN
300
301
GKVIQEIVDK SGVVRVRIEG DNENKLPRED GMVPFVFVGT KESIGNVQVL
350
351
LEYHIAYLKE VEQLRMERLQ IDEQLRQIGS RSYSGRGRGR RGPNYTSGYG
400
401
TNSELSNPSE TESERKDELS DWSLAGEDDR DSRHQRDSRR RPGGRGRSVS
450
451
GGRGRGGPRG GKSSISSVLK DPDSNPYSLL DNTESDQTAD TDASESHHST
500
501
NRRRRSRRRR TDEDAVLMDG MTESDTASVN ENGLVTVADY ISRAESQSRQ
550
551
RNLPRETLAK NKKEMAKDVI EEHGPSEKAI NGPTSASGDD ISKLQRTPGE
600
601
EKINTLKEEN TQEAAVLNGV S                               
621
 

Show the unformatted sequence.

Checksums:
CRC64:0474A9B593C7C228
MD5:5b6c9c9dfb486961181d2cbd6733c403

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Agenet 62 - 117 3KUF A 61 - 116 Jmol OpenAstexViewer
3O8V A 61 - 116 Jmol OpenAstexViewer
KH_1 283 - 289 2CPQ A 283 - 289 Jmol OpenAstexViewer
Tudor_FRX1 4 - 52 3KUF A 3 - 51 Jmol OpenAstexViewer
3O8V A 3 - 51 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.