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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: SMCA2_HUMAN (P51531)

Summary

This is the summary of UniProt entry SMCA2_HUMAN (P51531).

Description: Probable global transcription activator SNF2L2 EC=3.6.4.-
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 1590 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 346
low_complexity n/a 6 57
low_complexity n/a 95 112
low_complexity n/a 134 153
Pfam QLQ 173 207
coiled_coil n/a 212 238
low_complexity n/a 215 253
low_complexity n/a 261 274
low_complexity n/a 278 317
disorder n/a 354 356
disorder n/a 358 376
low_complexity n/a 382 393
disorder n/a 408 450
low_complexity n/a 429 449
Pfam HSA 437 507
disorder n/a 480 506
coiled_coil n/a 484 504
disorder n/a 509 515
disorder n/a 547 681
coiled_coil n/a 547 570
low_complexity n/a 547 567
Pfam BRK 589 632
low_complexity n/a 632 657
disorder n/a 688 690
Pfam SNF2_N 710 1022
low_complexity n/a 993 1002
disorder n/a 999 1000
Pfam Helicase_C 1050 1164
disorder n/a 1155 1160
disorder n/a 1215 1241
low_complexity n/a 1221 1236
Pfam SnAC 1244 1326
low_complexity n/a 1246 1263
disorder n/a 1257 1259
disorder n/a 1261 1279
disorder n/a 1281 1282
low_complexity n/a 1289 1300
disorder n/a 1296 1313
disorder n/a 1315 1317
disorder n/a 1327 1329
low_complexity n/a 1332 1354
coiled_coil n/a 1334 1354
disorder n/a 1337 1385
disorder n/a 1387 1389
disorder n/a 1406 1417
Pfam Bromodomain 1411 1493
disorder n/a 1426 1427
coiled_coil n/a 1499 1529
disorder n/a 1504 1590
low_complexity n/a 1508 1530
low_complexity n/a 1532 1546
low_complexity n/a 1542 1563
low_complexity n/a 1567 1585

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P51531. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSTPTDPGAM PHPGPSPGPG PSPGPILGPS PGPGPSPGSV HSMMGPSPGP
50
51
PSVSHPMPTM GSTDFPQEGM HQMHKPIDGI HDKGIVEDIH CGSMKGTGMR
100
101
PPHPGMGPPQ SPMDQHSQGY MSPHPSPLGA PEHVSSPMSG GGPTPPQMPP
150
151
SQPGALIPGD PQAMSQPNRG PSPFSPVQLH QLRAQILAYK MLARGQPLPE
200
201
TLQLAVQGKR TLPGLQQQQQ QQQQQQQQQQ QQQQQQQQPQ QQPPQPQTQQ
250
251
QQQPALVNYN RPSGPGPELS GPSTPQKLPV PAPGGRPSPA PPAAAQPPAA
300
301
AVPGPSVPQP APGQPSPVLQ LQQKQSRISP IQKPQGLDPV EILQEREYRL
350
351
QARIAHRIQE LENLPGSLPP DLRTKATVEL KALRLLNFQR QLRQEVVACM
400
401
RRDTTLETAL NSKAYKRSKR QTLREARMTE KLEKQQKIEQ ERKRRQKHQE
450
451
YLNSILQHAK DFKEYHRSVA GKIQKLSKAV ATWHANTERE QKKETERIEK
500
501
ERMRRLMAED EEGYRKLIDQ KKDRRLAYLL QQTDEYVANL TNLVWEHKQA
550
551
QAAKEKKKRR RRKKKAEENA EGGESALGPD GEPIDESSQM SDLPVKVTHT
600
601
ETGKVLFGPE APKASQLDAW LEMNPGYEVA PRSDSEESDS DYEEEDEEEE
650
651
SSRQETEEKI LLDPNSEEVS EKDAKQIIET AKQDVDDEYS MQYSARGSQS
700
701
YYTVAHAISE RVEKQSALLI NGTLKHYQLQ GLEWMVSLYN NNLNGILADE
750
751
MGLGKTIQTI ALITYLMEHK RLNGPYLIIV PLSTLSNWTY EFDKWAPSVV
800
801
KISYKGTPAM RRSLVPQLRS GKFNVLLTTY EYIIKDKHIL AKIRWKYMIV
850
851
DEGHRMKNHH CKLTQVLNTH YVAPRRILLT GTPLQNKLPE LWALLNFLLP
900
901
TIFKSCSTFE QWFNAPFAMT GERVDLNEEE TILIIRRLHK VLRPFLLRRL
950
951
KKEVESQLPE KVEYVIKCDM SALQKILYRH MQAKGILLTD GSEKDKKGKG
1000
1001
GAKTLMNTIM QLRKICNHPY MFQHIEESFA EHLGYSNGVI NGAELYRASG
1050
1051
KFELLDRILP KLRATNHRVL LFCQMTSLMT IMEDYFAFRN FLYLRLDGTT
1100
1101
KSEDRAALLK KFNEPGSQYF IFLLSTRAGG LGLNLQAADT VVIFDSDWNP
1150
1151
HQDLQAQDRA HRIGQQNEVR VLRLCTVNSV EEKILAAAKY KLNVDQKVIQ
1200
1201
AGMFDQKSSS HERRAFLQAI LEHEEENEEE DEVPDDETLN QMIARREEEF
1250
1251
DLFMRMDMDR RREDARNPKR KPRLMEEDEL PSWIIKDDAE VERLTCEEEE
1300
1301
EKIFGRGSRQ RRDVDYSDAL TEKQWLRAIE DGNLEEMEEE VRLKKRKRRR
1350
1351
NVDKDPAKED VEKAKKRRGR PPAEKLSPNP PKLTKQMNAI IDTVINYKDR
1400
1401
CNVEKVPSNS QLEIEGNSSG RQLSEVFIQL PSRKELPEYY ELIRKPVDFK
1450
1451
KIKERIRNHK YRSLGDLEKD VMLLCHNAQT FNLEGSQIYE DSIVLQSVFK
1500
1501
SARQKIAKEE ESEDESNEEE EEEDEEESES EAKSVKVKIK LNKKDDKGRD
1550
1551
KGKGKKRPNR GKAKPVVSDF DSDEEQDERE QSEGSGTDDE           
1590
 

Show the unformatted sequence.

Checksums:
CRC64:CE69BBB287D35AB5
MD5:d783e303e9d6e5e8268c96ed215b3263

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Bromodomain 1418 - 1493 2DAT A 31 - 106 Jmol OpenAstexViewer
4QY4 A 1400 - 1475 Jmol OpenAstexViewer
B 1400 - 1475 Jmol OpenAstexViewer
C 1400 - 1475 Jmol OpenAstexViewer
5DKC A 1400 - 1475 Jmol OpenAstexViewer
5DKH A 1400 - 1475 Jmol OpenAstexViewer
B 1400 - 1475 Jmol OpenAstexViewer
C 1400 - 1475 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.