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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: BRCA2_HUMAN (P51587)

Summary

This is the summary of UniProt entry BRCA2_HUMAN (P51587).

Description: Breast cancer type 2 susceptibility protein {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 3418 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 38 68
disorder n/a 73 74
disorder n/a 102 104
disorder n/a 112 123
disorder n/a 176 187
disorder n/a 191 197
low_complexity n/a 193 207
disorder n/a 205 209
disorder n/a 220 221
disorder n/a 232 234
disorder n/a 244 267
disorder n/a 277 279
disorder n/a 290 291
disorder n/a 293 296
disorder n/a 326 329
disorder n/a 334 336
disorder n/a 352 379
disorder n/a 425 427
disorder n/a 430 437
disorder n/a 439 471
disorder n/a 516 534
disorder n/a 540 541
disorder n/a 558 560
disorder n/a 644 645
disorder n/a 713 714
disorder n/a 722 724
disorder n/a 794 801
disorder n/a 803 811
disorder n/a 835 837
disorder n/a 844 847
disorder n/a 853 858
disorder n/a 860 863
disorder n/a 868 878
disorder n/a 902 905
disorder n/a 962 963
Pfam BRCA2 1005 1033
disorder n/a 1097 1098
disorder n/a 1102 1105
disorder n/a 1108 1110
disorder n/a 1153 1155
Pfam BRCA2 1215 1243
disorder n/a 1252 1253
disorder n/a 1255 1256
disorder n/a 1305 1337
disorder n/a 1400 1416
Pfam BRCA2 1424 1452
disorder n/a 1461 1464
disorder n/a 1501 1510
disorder n/a 1517 1520
Pfam BRCA2 1520 1548
disorder n/a 1602 1603
disorder n/a 1648 1651
Pfam BRCA2 1667 1695
disorder n/a 1709 1711
disorder n/a 1722 1739
low_complexity n/a 1741 1753
disorder n/a 1743 1744
disorder n/a 1774 1775
Pfam BRCA2 1974 2002
disorder n/a 2025 2033
low_complexity n/a 2052 2063
Pfam BRCA2 2054 2082
disorder n/a 2097 2100
disorder n/a 2102 2114
disorder n/a 2116 2120
disorder n/a 2137 2139
disorder n/a 2141 2144
disorder n/a 2149 2153
disorder n/a 2185 2188
disorder n/a 2190 2197
disorder n/a 2241 2242
disorder n/a 2246 2252
disorder n/a 2256 2257
disorder n/a 2264 2267
disorder n/a 2300 2311
disorder n/a 2336 2339
disorder n/a 2341 2351
disorder n/a 2379 2384
disorder n/a 2388 2404
disorder n/a 2407 2410
disorder n/a 2421 2425
disorder n/a 2427 2458
disorder n/a 2460 2461
disorder n/a 2465 2466
Pfam BRCA-2_helical 2481 2667
disorder n/a 2491 2492
disorder n/a 2494 2499
Pfam BRCA-2_OB1 2670 2796
low_complexity n/a 2792 2813
Pfam Tower 2831 2872
low_complexity n/a 2844 2860
disorder n/a 2852 2854
coiled_coil n/a 2855 2879
low_complexity n/a 2871 2878
disorder n/a 2876 2886
disorder n/a 2932 2934
disorder n/a 2947 2950
Pfam BRCA-2_OB3 3052 3186
coiled_coil n/a 3159 3179
disorder n/a 3202 3203
disorder n/a 3245 3247
disorder n/a 3250 3253
disorder n/a 3257 3259
low_complexity n/a 3274 3285
disorder n/a 3300 3301
disorder n/a 3309 3313
disorder n/a 3315 3316
disorder n/a 3319 3321
disorder n/a 3363 3368
disorder n/a 3373 3374
disorder n/a 3376 3378
disorder n/a 3391 3408

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P51587. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPIGSKERPT FFEIFKTRCN KADLGPISLN WFEELSSEAP PYNSEPAEES
50
51
EHKNNNYEPN LFKTPQRKPS YNQLASTPII FKEQGLTLPL YQSPVKELDK
100
101
FKLDLGRNVP NSRHKSLRTV KTKMDQADDV SCPLLNSCLS ESPVVLQCTH
150
151
VTPQRDKSVV CGSLFHTPKF VKGRQTPKHI SESLGAEVDP DMSWSSSLAT
200
201
PPTLSSTVLI VRNEEASETV FPHDTTANVK SYFSNHDESL KKNDRFIASV
250
251
TDSENTNQRE AASHGFGKTS GNSFKVNSCK DHIGKSMPNV LEDEVYETVV
300
301
DTSEEDSFSL CFSKCRTKNL QKVRTSKTRK KIFHEANADE CEKSKNQVKE
350
351
KYSFVSEVEP NDTDPLDSNV ANQKPFESGS DKISKEVVPS LACEWSQLTL
400
401
SGLNGAQMEK IPLLHISSCD QNISEKDLLD TENKRKKDFL TSENSLPRIS
450
451
SLPKSEKPLN EETVVNKRDE EQHLESHTDC ILAVKQAISG TSPVASSFQG
500
501
IKKSIFRIRE SPKETFNASF SGHMTDPNFK KETEASESGL EIHTVCSQKE
550
551
DSLCPNLIDN GSWPATTTQN SVALKNAGLI STLKKKTNKF IYAIHDETSY
600
601
KGKKIPKDQK SELINCSAQF EANAFEAPLT FANADSGLLH SSVKRSCSQN
650
651
DSEEPTLSLT SSFGTILRKC SRNETCSNNT VISQDLDYKE AKCNKEKLQL
700
701
FITPEADSLS CLQEGQCEND PKSKKVSDIK EEVLAAACHP VQHSKVEYSD
750
751
TDFQSQKSLL YDHENASTLI LTPTSKDVLS NLVMISRGKE SYKMSDKLKG
800
801
NNYESDVELT KNIPMEKNQD VCALNENYKN VELLPPEKYM RVASPSRKVQ
850
851
FNQNTNLRVI QKNQEETTSI SKITVNPDSE ELFSDNENNF VFQVANERNN
900
901
LALGNTKELH ETDLTCVNEP IFKNSTMVLY GDTGDKQATQ VSIKKDLVYV
950
951
LAEENKNSVK QHIKMTLGQD LKSDISLNID KIPEKNNDYM NKWAGLLGPI
1000
1001
SNHSFGGSFR TASNKEIKLS EHNIKKSKMF FKDIEEQYPT SLACVEIVNT
1050
1051
LALDNQKKLS KPQSINTVSA HLQSSVVVSD CKNSHITPQM LFSKQDFNSN
1100
1101
HNLTPSQKAE ITELSTILEE SGSQFEFTQF RKPSYILQKS TFEVPENQMT
1150
1151
ILKTTSEECR DADLHVIMNA PSIGQVDSSK QFEGTVEIKR KFAGLLKNDC
1200
1201
NKSASGYLTD ENEVGFRGFY SAHGTKLNVS TEALQKAVKL FSDIENISEE
1250
1251
TSAEVHPISL SSSKCHDSVV SMFKIENHND KTVSEKNNKC QLILQNNIEM
1300
1301
TTGTFVEEIT ENYKRNTENE DNKYTAASRN SHNLEFDGSD SSKNDTVCIH
1350
1351
KDETDLLFTD QHNICLKLSG QFMKEGNTQI KEDLSDLTFL EVAKAQEACH
1400
1401
GNTSNKEQLT ATKTEQNIKD FETSDTFFQT ASGKNISVAK ESFNKIVNFF
1450
1451
DQKPEELHNF SLNSELHSDI RKNKMDILSY EETDIVKHKI LKESVPVGTG
1500
1501
NQLVTFQGQP ERDEKIKEPT LLGFHTASGK KVKIAKESLD KVKNLFDEKE
1550
1551
QGTSEITSFS HQWAKTLKYR EACKDLELAC ETIEITAAPK CKEMQNSLNN
1600
1601
DKNLVSIETV VPPKLLSDNL CRQTENLKTS KSIFLKVKVH ENVEKETAKS
1650
1651
PATCYTNQSP YSVIENSALA FYTSCSRKTS VSQTSLLEAK KWLREGIFDG
1700
1701
QPERINTADY VGNYLYENNS NSTIAENDKN HLSEKQDTYL SNSSMSNSYS
1750
1751
YHSDEVYNDS GYLSKNKLDS GIEPVLKNVE DQKNTSFSKV ISNVKDANAY
1800
1801
PQTVNEDICV EELVTSSSPC KNKNAAIKLS ISNSNNFEVG PPAFRIASGK
1850
1851
IVCVSHETIK KVKDIFTDSF SKVIKENNEN KSKICQTKIM AGCYEALDDS
1900
1901
EDILHNSLDN DECSTHSHKV FADIQSEEIL QHNQNMSGLE KVSKISPCDV
1950
1951
SLETSDICKC SIGKLHKSVS SANTCGIFST ASGKSVQVSD ASLQNARQVF
2000
2001
SEIEDSTKQV FSKVLFKSNE HSDQLTREEN TAIRTPEHLI SQKGFSYNVV
2050
2051
NSSAFSGFST ASGKQVSILE SSLHKVKGVL EEFDLIRTEH SLHYSPTSRQ
2100
2101
NVSKILPRVD KRNPEHCVNS EMEKTCSKEF KLSNNLNVEG GSSENNHSIK
2150
2151
VSPYLSQFQQ DKQQLVLGTK VSLVENIHVL GKEQASPKNV KMEIGKTETF
2200
2201
SDVPVKTNIE VCSTYSKDSE NYFETEAVEI AKAFMEDDEL TDSKLPSHAT
2250
2251
HSLFTCPENE EMVLSNSRIG KRRGEPLILV GEPSIKRNLL NEFDRIIENQ
2300
2301
EKSLKASKST PDGTIKDRRL FMHHVSLEPI TCVPFRTTKE RQEIQNPNFT
2350
2351
APGQEFLSKS HLYEHLTLEK SSSNLAVSGH PFYQVSATRN EKMRHLITTG
2400
2401
RPTKVFVPPF KTKSHFHRVE QCVRNINLEE NRQKQNIDGH GSDDSKNKIN
2450
2451
DNEIHQFNKN NSNQAAAVTF TKCEEEPLDL ITSLQNARDI QDMRIKKKQR
2500
2501
QRVFPQPGSL YLAKTSTLPR ISLKAAVGGQ VPSACSHKQL YTYGVSKHCI
2550
2551
KINSKNAESF QFHTEDYFGK ESLWTGKGIQ LADGGWLIPS NDGKAGKEEF
2600
2601
YRALCDTPGV DPKLISRIWV YNHYRWIIWK LAAMECAFPK EFANRCLSPE
2650
2651
RVLLQLKYRY DTEIDRSRRS AIKKIMERDD TAAKTLVLCV SDIISLSANI
2700
2701
SETSSNKTSS ADTQKVAIIE LTDGWYAVKA QLDPPLLAVL KNGRLTVGQK
2750
2751
IILHGAELVG SPDACTPLEA PESLMLKISA NSTRPARWYT KLGFFPDPRP
2800
2801
FPLPLSSLFS DGGNVGCVDV IIQRAYPIQW MEKTSSGLYI FRNEREEEKE
2850
2851
AAKYVEAQQK RLEALFTKIQ EEFEEHEENT TKPYLPSRAL TRQQVRALQD
2900
2901
GAELYEAVKN AADPAYLEGY FSEEQLRALN NHRQMLNDKK QAQIQLEIRK
2950
2951
AMESAEQKEQ GLSRDVTTVW KLRIVSYSKK EKDSVILSIW RPSSDLYSLL
3000
3001
TEGKRYRIYH LATSKSKSKS ERANIQLAAT KKTQYQQLPV SDEILFQIYQ
3050
3051
PREPLHFSKF LDPDFQPSCS EVDLIGFVVS VVKKTGLAPF VYLSDECYNL
3100
3101
LAIKFWIDLN EDIIKPHMLI AASNLQWRPE SKSGLLTLFA GDFSVFSASP
3150
3151
KEGHFQETFN KMKNTVENID ILCNEAENKL MHILHANDPK WSTPTKDCTS
3200
3201
GPYTAQIIPG TGNKLLMSSP NCEIYYQSPL SLCMAKRKSV STPVSAQMTS
3250
3251
KSCKGEKEID DQKNCKKRRA LDFLSRLPLP PPVSPICTFV SPAAQKAFQP
3300
3301
PRSCGTKYET PIKKKELNSP QMTPFKKFNE ISLLESNSIA DEELALINTQ
3350
3351
ALLSGSTGEK QFISVSESTR TAPTSSEDYL RLKRRCTTSL IKEQESSQAS
3400
3401
TEECEKNKQD TITTKKYI                                   
3418
 

Show the unformatted sequence.

Checksums:
CRC64:6A0B3B7B332153EB
MD5:9bddbf031f3963d579b1f1025cabf5e1

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
BRCA2 1226 - 1229 6HQU N 1226 - 1229 Show 3D Structure View in InterPro
1226 - 1232 6HQU K 1226 - 1232 Show 3D Structure View in InterPro
1226 - 1243 6HQU I 1226 - 1243 Show 3D Structure View in InterPro
J 1226 - 1243 Show 3D Structure View in InterPro
L 1226 - 1243 Show 3D Structure View in InterPro
M 1226 - 1243 Show 3D Structure View in InterPro
1520 - 1548 1N0W B 1520 - 1548 Show 3D Structure View in InterPro
2054 - 2064 6HQU O 1230 - 2064 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.