Summary
This is the summary of UniProt entry BRCA2_HUMAN (P51587).
| Description: | Breast cancer type 2 susceptibility protein {ECO:0000305} |
| Source organism: |
Homo sapiens (Human)
(NCBI taxonomy ID
9606)
|
| Length: | 3418 amino acids |
| Reference Proteome: |
|
Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.
Pfam domains
Download the data used to generate the domain graphic in JSON format.
Show or hide the data used to generate the graphic in JSON format.
| Source | Domain | Start | End |
|---|---|---|---|
| disorder | n/a | 38 | 68 |
| disorder | n/a | 73 | 74 |
| disorder | n/a | 102 | 104 |
| disorder | n/a | 112 | 123 |
| disorder | n/a | 176 | 187 |
| disorder | n/a | 191 | 197 |
| low_complexity | n/a | 193 | 207 |
| disorder | n/a | 205 | 209 |
| disorder | n/a | 220 | 221 |
| disorder | n/a | 232 | 234 |
| disorder | n/a | 244 | 267 |
| disorder | n/a | 277 | 279 |
| disorder | n/a | 290 | 291 |
| disorder | n/a | 293 | 296 |
| disorder | n/a | 326 | 329 |
| disorder | n/a | 334 | 336 |
| disorder | n/a | 352 | 379 |
| disorder | n/a | 425 | 427 |
| disorder | n/a | 430 | 437 |
| disorder | n/a | 439 | 471 |
| disorder | n/a | 516 | 534 |
| disorder | n/a | 540 | 541 |
| disorder | n/a | 558 | 560 |
| disorder | n/a | 644 | 645 |
| disorder | n/a | 713 | 714 |
| disorder | n/a | 722 | 724 |
| disorder | n/a | 794 | 801 |
| disorder | n/a | 803 | 811 |
| disorder | n/a | 835 | 837 |
| disorder | n/a | 844 | 847 |
| disorder | n/a | 853 | 858 |
| disorder | n/a | 860 | 863 |
| disorder | n/a | 868 | 878 |
| disorder | n/a | 902 | 905 |
| disorder | n/a | 962 | 963 |
| Pfam | BRCA2 | 1005 | 1033 |
| disorder | n/a | 1097 | 1098 |
| disorder | n/a | 1102 | 1105 |
| disorder | n/a | 1108 | 1110 |
| disorder | n/a | 1153 | 1155 |
| Pfam | BRCA2 | 1215 | 1243 |
| disorder | n/a | 1252 | 1253 |
| disorder | n/a | 1255 | 1256 |
| disorder | n/a | 1305 | 1337 |
| disorder | n/a | 1400 | 1416 |
| Pfam | BRCA2 | 1424 | 1452 |
| disorder | n/a | 1461 | 1464 |
| disorder | n/a | 1501 | 1510 |
| disorder | n/a | 1517 | 1520 |
| Pfam | BRCA2 | 1520 | 1548 |
| disorder | n/a | 1602 | 1603 |
| disorder | n/a | 1648 | 1651 |
| Pfam | BRCA2 | 1667 | 1695 |
| disorder | n/a | 1709 | 1711 |
| disorder | n/a | 1722 | 1739 |
| low_complexity | n/a | 1741 | 1753 |
| disorder | n/a | 1743 | 1744 |
| disorder | n/a | 1774 | 1775 |
| Pfam | BRCA2 | 1974 | 2002 |
| disorder | n/a | 2025 | 2033 |
| low_complexity | n/a | 2052 | 2063 |
| Pfam | BRCA2 | 2054 | 2082 |
| disorder | n/a | 2097 | 2100 |
| disorder | n/a | 2102 | 2114 |
| disorder | n/a | 2116 | 2120 |
| disorder | n/a | 2137 | 2139 |
| disorder | n/a | 2141 | 2144 |
| disorder | n/a | 2149 | 2153 |
| disorder | n/a | 2185 | 2188 |
| disorder | n/a | 2190 | 2197 |
| disorder | n/a | 2241 | 2242 |
| disorder | n/a | 2246 | 2252 |
| disorder | n/a | 2256 | 2257 |
| disorder | n/a | 2264 | 2267 |
| disorder | n/a | 2300 | 2311 |
| disorder | n/a | 2336 | 2339 |
| disorder | n/a | 2341 | 2351 |
| disorder | n/a | 2379 | 2384 |
| disorder | n/a | 2388 | 2404 |
| disorder | n/a | 2407 | 2410 |
| disorder | n/a | 2421 | 2425 |
| disorder | n/a | 2427 | 2458 |
| disorder | n/a | 2460 | 2461 |
| disorder | n/a | 2465 | 2466 |
| Pfam | BRCA-2_helical | 2481 | 2667 |
| disorder | n/a | 2491 | 2492 |
| disorder | n/a | 2494 | 2499 |
| Pfam | BRCA-2_OB1 | 2670 | 2796 |
| low_complexity | n/a | 2792 | 2813 |
| Pfam | Tower | 2831 | 2872 |
| low_complexity | n/a | 2844 | 2860 |
| disorder | n/a | 2852 | 2854 |
| coiled_coil | n/a | 2855 | 2879 |
| low_complexity | n/a | 2871 | 2878 |
| disorder | n/a | 2876 | 2886 |
| disorder | n/a | 2932 | 2934 |
| disorder | n/a | 2947 | 2950 |
| Pfam | BRCA-2_OB3 | 3052 | 3186 |
| coiled_coil | n/a | 3159 | 3179 |
| disorder | n/a | 3202 | 3203 |
| disorder | n/a | 3245 | 3247 |
| disorder | n/a | 3250 | 3253 |
| disorder | n/a | 3257 | 3259 |
| low_complexity | n/a | 3274 | 3285 |
| disorder | n/a | 3300 | 3301 |
| disorder | n/a | 3309 | 3313 |
| disorder | n/a | 3315 | 3316 |
| disorder | n/a | 3319 | 3321 |
| disorder | n/a | 3363 | 3368 |
| disorder | n/a | 3373 | 3374 |
| disorder | n/a | 3376 | 3378 |
| disorder | n/a | 3391 | 3408 |
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Sequence information
This is the amino acid sequence of the UniProt sequence database entry with the accession P51587. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.
| Sequence: | 1
MPIGSKERPT FFEIFKTRCN KADLGPISLN WFEELSSEAP PYNSEPAEES
50 51
EHKNNNYEPN LFKTPQRKPS YNQLASTPII FKEQGLTLPL YQSPVKELDK
100 101
FKLDLGRNVP NSRHKSLRTV KTKMDQADDV SCPLLNSCLS ESPVVLQCTH
150 151
VTPQRDKSVV CGSLFHTPKF VKGRQTPKHI SESLGAEVDP DMSWSSSLAT
200 201
PPTLSSTVLI VRNEEASETV FPHDTTANVK SYFSNHDESL KKNDRFIASV
250 251
TDSENTNQRE AASHGFGKTS GNSFKVNSCK DHIGKSMPNV LEDEVYETVV
300 301
DTSEEDSFSL CFSKCRTKNL QKVRTSKTRK KIFHEANADE CEKSKNQVKE
350 351
KYSFVSEVEP NDTDPLDSNV ANQKPFESGS DKISKEVVPS LACEWSQLTL
400 401
SGLNGAQMEK IPLLHISSCD QNISEKDLLD TENKRKKDFL TSENSLPRIS
450 451
SLPKSEKPLN EETVVNKRDE EQHLESHTDC ILAVKQAISG TSPVASSFQG
500 501
IKKSIFRIRE SPKETFNASF SGHMTDPNFK KETEASESGL EIHTVCSQKE
550 551
DSLCPNLIDN GSWPATTTQN SVALKNAGLI STLKKKTNKF IYAIHDETSY
600 601
KGKKIPKDQK SELINCSAQF EANAFEAPLT FANADSGLLH SSVKRSCSQN
650 651
DSEEPTLSLT SSFGTILRKC SRNETCSNNT VISQDLDYKE AKCNKEKLQL
700 701
FITPEADSLS CLQEGQCEND PKSKKVSDIK EEVLAAACHP VQHSKVEYSD
750 751
TDFQSQKSLL YDHENASTLI LTPTSKDVLS NLVMISRGKE SYKMSDKLKG
800 801
NNYESDVELT KNIPMEKNQD VCALNENYKN VELLPPEKYM RVASPSRKVQ
850 851
FNQNTNLRVI QKNQEETTSI SKITVNPDSE ELFSDNENNF VFQVANERNN
900 901
LALGNTKELH ETDLTCVNEP IFKNSTMVLY GDTGDKQATQ VSIKKDLVYV
950 951
LAEENKNSVK QHIKMTLGQD LKSDISLNID KIPEKNNDYM NKWAGLLGPI
1000 1001
SNHSFGGSFR TASNKEIKLS EHNIKKSKMF FKDIEEQYPT SLACVEIVNT
1050 1051
LALDNQKKLS KPQSINTVSA HLQSSVVVSD CKNSHITPQM LFSKQDFNSN
1100 1101
HNLTPSQKAE ITELSTILEE SGSQFEFTQF RKPSYILQKS TFEVPENQMT
1150 1151
ILKTTSEECR DADLHVIMNA PSIGQVDSSK QFEGTVEIKR KFAGLLKNDC
1200 1201
NKSASGYLTD ENEVGFRGFY SAHGTKLNVS TEALQKAVKL FSDIENISEE
1250 1251
TSAEVHPISL SSSKCHDSVV SMFKIENHND KTVSEKNNKC QLILQNNIEM
1300 1301
TTGTFVEEIT ENYKRNTENE DNKYTAASRN SHNLEFDGSD SSKNDTVCIH
1350 1351
KDETDLLFTD QHNICLKLSG QFMKEGNTQI KEDLSDLTFL EVAKAQEACH
1400 1401
GNTSNKEQLT ATKTEQNIKD FETSDTFFQT ASGKNISVAK ESFNKIVNFF
1450 1451
DQKPEELHNF SLNSELHSDI RKNKMDILSY EETDIVKHKI LKESVPVGTG
1500 1501
NQLVTFQGQP ERDEKIKEPT LLGFHTASGK KVKIAKESLD KVKNLFDEKE
1550 1551
QGTSEITSFS HQWAKTLKYR EACKDLELAC ETIEITAAPK CKEMQNSLNN
1600 1601
DKNLVSIETV VPPKLLSDNL CRQTENLKTS KSIFLKVKVH ENVEKETAKS
1650 1651
PATCYTNQSP YSVIENSALA FYTSCSRKTS VSQTSLLEAK KWLREGIFDG
1700 1701
QPERINTADY VGNYLYENNS NSTIAENDKN HLSEKQDTYL SNSSMSNSYS
1750 1751
YHSDEVYNDS GYLSKNKLDS GIEPVLKNVE DQKNTSFSKV ISNVKDANAY
1800 1801
PQTVNEDICV EELVTSSSPC KNKNAAIKLS ISNSNNFEVG PPAFRIASGK
1850 1851
IVCVSHETIK KVKDIFTDSF SKVIKENNEN KSKICQTKIM AGCYEALDDS
1900 1901
EDILHNSLDN DECSTHSHKV FADIQSEEIL QHNQNMSGLE KVSKISPCDV
1950 1951
SLETSDICKC SIGKLHKSVS SANTCGIFST ASGKSVQVSD ASLQNARQVF
2000 2001
SEIEDSTKQV FSKVLFKSNE HSDQLTREEN TAIRTPEHLI SQKGFSYNVV
2050 2051
NSSAFSGFST ASGKQVSILE SSLHKVKGVL EEFDLIRTEH SLHYSPTSRQ
2100 2101
NVSKILPRVD KRNPEHCVNS EMEKTCSKEF KLSNNLNVEG GSSENNHSIK
2150 2151
VSPYLSQFQQ DKQQLVLGTK VSLVENIHVL GKEQASPKNV KMEIGKTETF
2200 2201
SDVPVKTNIE VCSTYSKDSE NYFETEAVEI AKAFMEDDEL TDSKLPSHAT
2250 2251
HSLFTCPENE EMVLSNSRIG KRRGEPLILV GEPSIKRNLL NEFDRIIENQ
2300 2301
EKSLKASKST PDGTIKDRRL FMHHVSLEPI TCVPFRTTKE RQEIQNPNFT
2350 2351
APGQEFLSKS HLYEHLTLEK SSSNLAVSGH PFYQVSATRN EKMRHLITTG
2400 2401
RPTKVFVPPF KTKSHFHRVE QCVRNINLEE NRQKQNIDGH GSDDSKNKIN
2450 2451
DNEIHQFNKN NSNQAAAVTF TKCEEEPLDL ITSLQNARDI QDMRIKKKQR
2500 2501
QRVFPQPGSL YLAKTSTLPR ISLKAAVGGQ VPSACSHKQL YTYGVSKHCI
2550 2551
KINSKNAESF QFHTEDYFGK ESLWTGKGIQ LADGGWLIPS NDGKAGKEEF
2600 2601
YRALCDTPGV DPKLISRIWV YNHYRWIIWK LAAMECAFPK EFANRCLSPE
2650 2651
RVLLQLKYRY DTEIDRSRRS AIKKIMERDD TAAKTLVLCV SDIISLSANI
2700 2701
SETSSNKTSS ADTQKVAIIE LTDGWYAVKA QLDPPLLAVL KNGRLTVGQK
2750 2751
IILHGAELVG SPDACTPLEA PESLMLKISA NSTRPARWYT KLGFFPDPRP
2800 2801
FPLPLSSLFS DGGNVGCVDV IIQRAYPIQW MEKTSSGLYI FRNEREEEKE
2850 2851
AAKYVEAQQK RLEALFTKIQ EEFEEHEENT TKPYLPSRAL TRQQVRALQD
2900 2901
GAELYEAVKN AADPAYLEGY FSEEQLRALN NHRQMLNDKK QAQIQLEIRK
2950 2951
AMESAEQKEQ GLSRDVTTVW KLRIVSYSKK EKDSVILSIW RPSSDLYSLL
3000 3001
TEGKRYRIYH LATSKSKSKS ERANIQLAAT KKTQYQQLPV SDEILFQIYQ
3050 3051
PREPLHFSKF LDPDFQPSCS EVDLIGFVVS VVKKTGLAPF VYLSDECYNL
3100 3101
LAIKFWIDLN EDIIKPHMLI AASNLQWRPE SKSGLLTLFA GDFSVFSASP
3150 3151
KEGHFQETFN KMKNTVENID ILCNEAENKL MHILHANDPK WSTPTKDCTS
3200 3201
GPYTAQIIPG TGNKLLMSSP NCEIYYQSPL SLCMAKRKSV STPVSAQMTS
3250 3251
KSCKGEKEID DQKNCKKRRA LDFLSRLPLP PPVSPICTFV SPAAQKAFQP
3300 3301
PRSCGTKYET PIKKKELNSP QMTPFKKFNE ISLLESNSIA DEELALINTQ
3350 3351
ALLSGSTGEK QFISVSESTR TAPTSSEDYL RLKRRCTTSL IKEQESSQAS
3400 3401
TEECEKNKQD TITTKKYI
3418
Show the unformatted sequence. |
| Checksums: |
CRC64:6A0B3B7B332153EB
MD5:9bddbf031f3963d579b1f1025cabf5e1
|
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.
| Pfam family | UniProt residues | PDB ID | PDB chain ID | PDB residues | View |
|---|---|---|---|---|---|
| BRCA2 | 1226 - 1229 | 6HQU | N | 1226 - 1229 | Show 3D Structure View in InterPro |
| 1226 - 1232 | 6HQU | K | 1226 - 1232 | Show 3D Structure View in InterPro | |
| 1226 - 1243 | 6HQU | I | 1226 - 1243 | Show 3D Structure View in InterPro | |
| J | 1226 - 1243 | Show 3D Structure View in InterPro | |||
| L | 1226 - 1243 | Show 3D Structure View in InterPro | |||
| M | 1226 - 1243 | Show 3D Structure View in InterPro | |||
| 1520 - 1548 | 1N0W | B | 1520 - 1548 | Show 3D Structure View in InterPro | |
| 2054 - 2064 | 6HQU | O | 1230 - 2064 | Show 3D Structure View in InterPro |
×
The parts of the structure corresponding to the Pfam family are highlighted in blue.
Loading Structure Data
TreeFam
Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.
