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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: IRAK1_HUMAN (P51617)

Summary

This is the summary of UniProt entry IRAK1_HUMAN (P51617).

Description: Interleukin-1 receptor-associated kinase 1 EC=2.7.11.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 712 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 8
low_complexity n/a 1 14
Pfam Death 27 103
disorder n/a 104 130
low_complexity n/a 114 132
disorder n/a 141 142
disorder n/a 145 148
disorder n/a 153 156
disorder n/a 158 186
low_complexity n/a 161 182
Pfam Pkinase 212 517
low_complexity n/a 438 444
disorder n/a 448 449
low_complexity n/a 457 469
low_complexity n/a 477 495
disorder n/a 484 486
low_complexity n/a 488 500
disorder n/a 511 513
disorder n/a 532 596
low_complexity n/a 561 574
disorder n/a 606 608
disorder n/a 610 664
low_complexity n/a 642 657
disorder n/a 666 667
disorder n/a 672 674
low_complexity n/a 678 696
disorder n/a 687 712

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P51617. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAGGPGPGEP AAPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV
50
51
RDQTELRLCE RSGQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT
100
101
AWHPPAPLPS PGTTAPRPSS IPAPAEAEAW SPRKLPSSAS TFLSPAFPGS
150
151
QTHSGPELGL VPSPASLWPP PPSPAPSSTK PGPESSVSLL QGARPFPFCW
200
201
PLCEISRGTH NFSEELKIGE GGFGCVYRAV MRNTVYAVKR LKENADLEWT
250
251
AVKQSFLTEV EQLSRFRHPN IVDFAGYCAQ NGFYCLVYGF LPNGSLEDRL
300
301
HCQTQACPPL SWPQRLDILL GTARAIQFLH QDSPSLIHGD IKSSNVLLDE
350
351
RLTPKLGDFG LARFSRFAGS SPSQSSMVAR TQTVRGTLAY LPEEYIKTGR
400
401
LAVDTDTFSF GVVVLETLAG QRAVKTHGAR TKYLKDLVEE EAEEAGVALR
450
451
STQSTLQAGL AADAWAAPIA MQIYKKHLDP RPGPCPPELG LGLGQLACCC
500
501
LHRRAKRRPP MTQVYERLEK LQAVVAGVPG HSEAASCIPP SPQENSYVSS
550
551
TGRAHSGAAP WQPLAAPSGA SAQAAEQLQR GPNQPVESDE SLGGLSAALR
600
601
SWHLTPSCPL DPAPLREAGC PQGDTAGESS WGSGPGSRPT AVEGLALGSS
650
651
ASSSSEPPQI IINPARQKMV QKLALYEDGA LDSLQLLSSS SLPGLGLEQD
700
701
RQGPEESDEF QS                                         
712
 

Show the unformatted sequence.

Checksums:
CRC64:A7ADED75D3A3981D
MD5:7c465f9a42dc946204c257c884beda6a

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Pkinase 212 - 517 6BFN A 212 - 517 Jmol OpenAstexViewer
B 212 - 517 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.