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2  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CLCN5_HUMAN (P51795)

Summary

This is the summary of UniProt entry CLCN5_HUMAN (P51795).

Description: H(+)/Cl(-) exchange transporter 5
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 746 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 33 34
transmembrane n/a 55 75
low_complexity n/a 55 77
transmembrane n/a 133 155
low_complexity n/a 143 161
Pfam Voltage_CLC 149 551
transmembrane n/a 161 182
transmembrane n/a 189 208
low_complexity n/a 197 208
transmembrane n/a 242 266
low_complexity n/a 243 256
transmembrane n/a 278 296
transmembrane n/a 316 337
low_complexity n/a 321 336
transmembrane n/a 357 374
transmembrane n/a 427 447
transmembrane n/a 454 473
transmembrane n/a 501 526
Pfam CBS 582 646
low_complexity n/a 666 676
Pfam CBS 679 734

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P51795. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MDFLEEPIPG VGTYDDFNTI DWVREKSRDR DRHREITNKS KESTWALIHS
50
51
VSDAFSGWLL MLLIGLLSGS LAGLIDISAH WMTDLKEGIC TGGFWFNHEH
100
101
CCWNSEHVTF EERDKCPEWN SWSQLIISTD EGAFAYIVNY FMYVLWALLF
150
151
AFLAVSLVKV FAPYACGSGI PEIKTILSGF IIRGYLGKWT LVIKTITLVL
200
201
AVSSGLSLGK EGPLVHVACC CGNILCHCFN KYRKNEAKRR EVLSAAAAAG
250
251
VSVAFGAPIG GVLFSLEEVS YYFPLKTLWR SFFAALVAAF TLRSINPFGN
300
301
SRLVLFYVEF HTPWHLFELV PFILLGIFGG LWGALFIRTN IAWCRKRKTT
350
351
QLGKYPVIEV LVVTAITAIL AFPNEYTRMS TSELISELFN DCGLLDSSKL
400
401
CDYENRFNTS KGGELPDRPA GVGVYSAMWQ LALTLILKIV ITIFTFGMKI
450
451
PSGLFIPSMA VGAIAGRLLG VGMEQLAYYH QEWTVFNSWC SQGADCITPG
500
501
LYAMVGAAAC LGGVTRMTVS LVVIMFELTG GLEYIVPLMA AAMTSKWVAD
550
551
ALGREGIYDA HIRLNGYPFL EAKEEFAHKT LAMDVMKPRR NDPLLTVLTQ
600
601
DSMTVEDVET IISETTYSGF PVVVSRESQR LVGFVLRRDL IISIENARKK
650
651
QDGVVSTSII YFTEHSPPLP PYTPPTLKLR NILDLSPFTV TDLTPMEIVV
700
701
DIFRKLGLRQ CLVTHNGRLL GIITKKDVLK HIAQMANQDP DSILFN    
746
 

Show the unformatted sequence.

Checksums:
CRC64:EF913C5BA40C85D8
MD5:7806f3d8418bb20918b8df8066883498

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
CBS 582 - 646 2J9L A 582 - 646 Jmol OpenAstexViewer
B 582 - 646 Jmol OpenAstexViewer
C 582 - 646 Jmol OpenAstexViewer
D 582 - 646 Jmol OpenAstexViewer
E 582 - 646 Jmol OpenAstexViewer
F 582 - 646 Jmol OpenAstexViewer
2JA3 A 582 - 646 Jmol OpenAstexViewer
B 582 - 646 Jmol OpenAstexViewer
C 582 - 646 Jmol OpenAstexViewer
D 582 - 646 Jmol OpenAstexViewer
E 582 - 646 Jmol OpenAstexViewer
F 582 - 646 Jmol OpenAstexViewer
679 - 734 2J9L A 679 - 734 Jmol OpenAstexViewer
B 679 - 734 Jmol OpenAstexViewer
C 679 - 734 Jmol OpenAstexViewer
D 679 - 734 Jmol OpenAstexViewer
E 679 - 734 Jmol OpenAstexViewer
F 679 - 734 Jmol OpenAstexViewer
2JA3 A 679 - 734 Jmol OpenAstexViewer
B 679 - 734 Jmol OpenAstexViewer
C 679 - 734 Jmol OpenAstexViewer
D 679 - 734 Jmol OpenAstexViewer
E 679 - 734 Jmol OpenAstexViewer
F 679 - 734 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.