Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NEK4_HUMAN (P51957)

Summary

This is the summary of UniProt entry NEK4_HUMAN (P51957).

Description: Serine/threonine-protein kinase Nek4
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 841 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

Show or hide the data used to generate the graphic in JSON format.

Source Domain Start End
Pfam Pkinase 6 261
low_complexity n/a 36 56
disorder n/a 241 242
disorder n/a 248 249
low_complexity n/a 271 282
disorder n/a 278 283
disorder n/a 285 300
disorder n/a 302 314
disorder n/a 317 325
disorder n/a 330 333
disorder n/a 337 341
disorder n/a 347 350
disorder n/a 376 389
disorder n/a 410 432
disorder n/a 435 460
disorder n/a 477 479
disorder n/a 481 485
disorder n/a 489 497
disorder n/a 508 664
low_complexity n/a 533 542
low_complexity n/a 589 607
disorder n/a 668 669
disorder n/a 671 706
low_complexity n/a 675 688
disorder n/a 720 724
low_complexity n/a 799 815

Show or hide domain scores.

Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P51957. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MPLAAYCYLR VVGKGSYGEV TLVKHRRDGK QYVIKKLNLR NASSRERRAA
50
51
EQEAQLLSQL KHPNIVTYKE SWEGGDGLLY IVMGFCEGGD LYRKLKEQKG
100
101
QLLPENQVVE WFVQIAMALQ YLHEKHILHR DLKTQNVFLT RTNIIKVGDL
150
151
GIARVLENHC DMASTLIGTP YYMSPELFSN KPYNYKSDVW ALGCCVYEMA
200
201
TLKHAFNAKD MNSLVYRIIE GKLPPMPRDY SPELAELIRT MLSKRPEERP
250
251
SVRSILRQPY IKRQISFFLE ATKIKTSKNN IKNGDSQSKP FATVVSGEAE
300
301
SNHEVIHPQP LSSEGSQTYI MGEGKCLSQE KPRASGLLKS PASLKAHTCK
350
351
QDLSNTTELA TISSVNIDIL PAKGRDSVSD GFVQENQPRY LDASNELGGI
400
401
CSISQVEEEM LQDNTKSSAQ PENLIPMWSS DIVTGEKNEP VKPLQPLIKE
450
451
QKPKDQSLAL SPKLECSGTI LAHSNLRLLG SSDSPASASR VAGITGVCHH
500
501
AQDQVAGECI IEKQGRIHPD LQPHNSGSEP SLSRQRRQKR REQTEHRGEK
550
551
RQVRRDLFAF QESPPRFLPS HPIVGKVDVT STQKEAENQR RVVTGSVSSS
600
601
RSSEMSSSKD RPLSARERRR LKQSQEEMSS SGPSVRKASL SVAGPGKPQE
650
651
EDQPLPARRL SSDCSVTQER KQIHCLSEDE LSSSTSSTDK SDGDYGEGKG
700
701
QTNEINALVQ LMTQTLKLDS KESCEDVPVA NPVSEFKLHR KYRDTLILHG
750
751
KVAEEAEEIH FKELPSAIMP GSEKIRRLVE VLRTDVIRGL GVQLLEQVYD
800
801
LLEEEDEFDR EVRLREHMGE KYTTYSVKAR QLKFFEENMN F         
841
 

Show the unformatted sequence.

Checksums:
CRC64:43E8F11BA4007263
MD5:82e1ef0871fe512226d2b7508b3f4dbe

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.