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4  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: UB2E1_HUMAN (P51965)

Summary

This is the summary of UniProt entry UB2E1_HUMAN (P51965).

Description: Ubiquitin-conjugating enzyme E2 E1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 193 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 40
low_complexity n/a 1 17
low_complexity n/a 21 34
Pfam UQ_con 51 188
disorder n/a 60 65
disorder n/a 70 72

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P51965. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSDDDSRAST SSSSSSSSNQ QTEKETNTPK KKESKVSMSK NSKLLSTSAK
50
51
RIQKELADIT LDPPPNCSAG PKGDNIYEWR STILGPPGSV YEGGVFFLDI
100
101
TFTPEYPFKP PKVTFRTRIY HCNINSQGVI CLDILKDNWS PALTISKVLL
150
151
SICSLLTDCN PADPLVGSIA TQYMTNRAEH DRMARQWTKR YAT       
193
 

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Checksums:
CRC64:2FBC50BE2A6A0008
MD5:b401c78948bda9fe95db1ef8dd55a1cf

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
UQ_con 51 - 188 3BZH A 51 - 188 Jmol OpenAstexViewer
5LBN A 51 - 188 Jmol OpenAstexViewer
6FGA I 51 - 188 Jmol OpenAstexViewer
J 51 - 188 Jmol OpenAstexViewer
K 51 - 188 Jmol OpenAstexViewer
L 51 - 188 Jmol OpenAstexViewer
M 51 - 188 Jmol OpenAstexViewer
N 51 - 188 Jmol OpenAstexViewer
O 51 - 188 Jmol OpenAstexViewer
83 - 91 1XR9 C 1 - 9 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.