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11  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: NCBP2_HUMAN (P52298)

Summary

This is the summary of UniProt entry NCBP2_HUMAN (P52298).

Description: Nuclear cap-binding protein subunit 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 156 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
Pfam RRM_1 42 112
low_complexity n/a 121 134
disorder n/a 130 131
disorder n/a 136 137

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P52298. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSGGLLKALR SDSYVELSQY RDQHFRGDNE EQEKLLKKSC TLYVGNLSFY
50
51
TTEEQIYELF SKSGDIKKII MGLDKMKKTA CGFCFVEYYS RADAENAMRY
100
101
INGTRLDDRI IRTDWDAGFK EGRQYGRGRS GGQVRDEYRQ DYDAGRGGYG
150
151
KLAQNQ                                                
156
 

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Checksums:
CRC64:B6C94F3182A2CC3D
MD5:8838d8ffd316f18b4fb7059cf674f4ec

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
RRM_1 42 - 112 1H2T Z 42 - 112 Jmol OpenAstexViewer
1H2U X 42 - 112 Jmol OpenAstexViewer
Y 42 - 112 Jmol OpenAstexViewer
1H2V Z 42 - 112 Jmol OpenAstexViewer
1H6K X 42 - 112 Jmol OpenAstexViewer
Y 42 - 112 Jmol OpenAstexViewer
Z 42 - 112 Jmol OpenAstexViewer
1N52 B 42 - 112 Jmol OpenAstexViewer
1N54 B 42 - 112 Jmol OpenAstexViewer
3FEX B 42 - 112 Jmol OpenAstexViewer
3FEY B 42 - 112 Jmol OpenAstexViewer
5OO6 B 42 - 112 Jmol OpenAstexViewer
E 42 - 112 Jmol OpenAstexViewer
H 42 - 112 Jmol OpenAstexViewer
K 42 - 112 Jmol OpenAstexViewer
N 42 - 112 Jmol OpenAstexViewer
Q 42 - 112 Jmol OpenAstexViewer
T 42 - 112 Jmol OpenAstexViewer
W 42 - 112 Jmol OpenAstexViewer
5OOB B 42 - 112 Jmol OpenAstexViewer
D 42 - 112 Jmol OpenAstexViewer
G 42 - 112 Jmol OpenAstexViewer
J 42 - 112 Jmol OpenAstexViewer
6D0Y A 42 - 112 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.