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18  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PPP5_HUMAN (P53041)

Summary

This is the summary of UniProt entry PPP5_HUMAN (P53041).

Description: Serine/threonine-protein phosphatase 5 EC=3.1.3.16
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 499 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 4 27
Pfam TPR_1 28 61
Pfam PPP5 136 228
low_complexity n/a 218 235
Pfam Metallophos 235 431
disorder n/a 367 370
disorder n/a 380 385
disorder n/a 397 399
disorder n/a 475 476

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P53041. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MAMAEGERTE CAEPPRDEPP ADGALKRAEE LKTQANDYFK AKDYENAIKF
50
51
YSQAIELNPS NAIYYGNRSL AYLRTECYGY ALGDATRAIE LDKKYIKGYY
100
101
RRAASNMALG KFRAALRDYE TVVKVKPHDK DAKMKYQECN KIVKQKAFER
150
151
AIAGDEHKRS VVDSLDIESM TIEDEYSGPK LEDGKVTISF MKELMQWYKD
200
201
QKKLHRKCAY QILVQVKEVL SKLSTLVETT LKETEKITVC GDTHGQFYDL
250
251
LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL
300
301
RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI
350
351
MHGGLFSEDG VTLDDIRKIE RNRQPPDSGP MCDLLWSDPQ PQNGRSISKR
400
401
GVSCQFGPDV TKAFLEENNL DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN
450
451
YCDQMGNKAS YIHLQGSDLR PQFHQFTAVP HPNVKPMAYA NTLLQLGMM 
499
 

Show the unformatted sequence.

Checksums:
CRC64:DB3B2090D8658BB3
MD5:92888a2e9f1c07cc5769a59d74299f5b

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Metallophos 235 - 431 1S95 A 235 - 431 Jmol OpenAstexViewer
B 235 - 431 Jmol OpenAstexViewer
1WAO 1 235 - 431 Jmol OpenAstexViewer
2 235 - 431 Jmol OpenAstexViewer
3 235 - 431 Jmol OpenAstexViewer
4 235 - 431 Jmol OpenAstexViewer
3H60 A 235 - 431 Jmol OpenAstexViewer
B 235 - 431 Jmol OpenAstexViewer
3H61 A 235 - 431 Jmol OpenAstexViewer
D 235 - 431 Jmol OpenAstexViewer
3H62 B 235 - 431 Jmol OpenAstexViewer
C 235 - 431 Jmol OpenAstexViewer
3H63 A 235 - 431 Jmol OpenAstexViewer
C 235 - 431 Jmol OpenAstexViewer
3H64 A 235 - 431 Jmol OpenAstexViewer
D 235 - 431 Jmol OpenAstexViewer
3H66 A 235 - 431 Jmol OpenAstexViewer
B 235 - 431 Jmol OpenAstexViewer
3H67 A 235 - 431 Jmol OpenAstexViewer
D 235 - 431 Jmol OpenAstexViewer
3H68 A 235 - 431 Jmol OpenAstexViewer
D 235 - 431 Jmol OpenAstexViewer
3H69 A 235 - 431 Jmol OpenAstexViewer
D 235 - 431 Jmol OpenAstexViewer
4ZVZ A 235 - 431 Jmol OpenAstexViewer
B 235 - 431 Jmol OpenAstexViewer
C 235 - 431 Jmol OpenAstexViewer
D 235 - 431 Jmol OpenAstexViewer
4ZX2 A 235 - 431 Jmol OpenAstexViewer
5HPE A 235 - 431 Jmol OpenAstexViewer
5UI1 A 235 - 431 Jmol OpenAstexViewer
B 235 - 431 Jmol OpenAstexViewer
C 235 - 431 Jmol OpenAstexViewer
D 235 - 431 Jmol OpenAstexViewer
5WG8 A 235 - 431 Jmol OpenAstexViewer
PPP5 136 - 147 2BUG A 136 - 147 Jmol OpenAstexViewer
136 - 177 1A17 A 136 - 177 Jmol OpenAstexViewer
136 - 228 1WAO 1 136 - 228 Jmol OpenAstexViewer
2 136 - 228 Jmol OpenAstexViewer
3 136 - 228 Jmol OpenAstexViewer
4 136 - 228 Jmol OpenAstexViewer
169 - 228 4ZX2 A 169 - 228 Jmol OpenAstexViewer
172 - 228 5WG8 A 172 - 228 Jmol OpenAstexViewer
175 - 228 1S95 B 175 - 228 Jmol OpenAstexViewer
4ZVZ B 175 - 228 Jmol OpenAstexViewer
5HPE A 175 - 228 Jmol OpenAstexViewer
176 - 228 1S95 A 176 - 228 Jmol OpenAstexViewer
3H60 A 176 - 228 Jmol OpenAstexViewer
B 176 - 228 Jmol OpenAstexViewer
3H61 A 176 - 228 Jmol OpenAstexViewer
D 176 - 228 Jmol OpenAstexViewer
3H62 B 176 - 228 Jmol OpenAstexViewer
C 176 - 228 Jmol OpenAstexViewer
3H63 A 176 - 228 Jmol OpenAstexViewer
C 176 - 228 Jmol OpenAstexViewer
3H64 A 176 - 228 Jmol OpenAstexViewer
3H66 A 176 - 228 Jmol OpenAstexViewer
B 176 - 228 Jmol OpenAstexViewer
3H67 A 176 - 228 Jmol OpenAstexViewer
D 176 - 228 Jmol OpenAstexViewer
3H68 A 176 - 228 Jmol OpenAstexViewer
D 176 - 228 Jmol OpenAstexViewer
3H69 A 176 - 228 Jmol OpenAstexViewer
D 176 - 228 Jmol OpenAstexViewer
4ZVZ A 176 - 228 Jmol OpenAstexViewer
5UI1 C 176 - 228 Jmol OpenAstexViewer
178 - 228 4ZVZ D 178 - 228 Jmol OpenAstexViewer
5UI1 A 178 - 228 Jmol OpenAstexViewer
B 178 - 228 Jmol OpenAstexViewer
179 - 228 4ZVZ C 179 - 228 Jmol OpenAstexViewer
5UI1 D 179 - 228 Jmol OpenAstexViewer
182 - 228 3H64 D 182 - 228 Jmol OpenAstexViewer
TPR_1 28 - 61 1A17 A 28 - 61 Jmol OpenAstexViewer
1WAO 1 28 - 61 Jmol OpenAstexViewer
2 28 - 61 Jmol OpenAstexViewer
3 28 - 61 Jmol OpenAstexViewer
4 28 - 61 Jmol OpenAstexViewer
2BUG A 28 - 61 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.