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18  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CATC_HUMAN (P53634)

Summary

This is the summary of UniProt entry CATC_HUMAN (P53634).

Description: Dipeptidyl peptidase 1 EC=3.4.14.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 463 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 24
low_complexity n/a 7 16
Pfam CathepsinC_exc 25 141
disorder n/a 207 217
Pfam Peptidase_C1 231 458

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P53634. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MGAGPSLLLA ALLLLLSGDG AVRCDTPANC TYLDLLGTWV FQVGSSGSQR
50
51
DVNCSVMGPQ EKKVVVYLQK LDTAYDDLGN SGHFTIIYNQ GFEIVLNDYK
100
101
WFAFFKYKEE GSKVTTYCNE TMTGWVHDVL GRNWACFTGK KVGTASENVY
150
151
VNIAHLKNSQ EKYSNRLYKY DHNFVKAINA IQKSWTATTY MEYETLTLGD
200
201
MIRRSGGHSR KIPRPKPAPL TAEIQQKILH LPTSWDWRNV HGINFVSPVR
250
251
NQASCGSCYS FASMGMLEAR IRILTNNSQT PILSPQEVVS CSQYAQGCEG
300
301
GFPYLIAGKY AQDFGLVEEA CFPYTGTDSP CKMKEDCFRY YSSEYHYVGG
350
351
FYGGCNEALM KLELVHHGPM AVAFEVYDDF LHYKKGIYHH TGLRDPFNPF
400
401
ELTNHAVLLV GYGTDSASGM DYWIVKNSWG TGWGENGYFR IRRGTDECAI
450
451
ESIAVAATPI PKL                                        
463
 

Show the unformatted sequence.

Checksums:
CRC64:4C9C7C24D900CEE6
MD5:e8a46a7d094fbf58310ba4338a003c1c

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
CathepsinC_exc 25 - 141 1K3B A 1 - 117 Show 3D Structure View in InterPro
2DJF A 1 - 117 Show 3D Structure View in InterPro
2DJG A 1 - 117 Show 3D Structure View in InterPro
3PDF A 1 - 117 Show 3D Structure View in InterPro
4CDC A 1 - 117 Show 3D Structure View in InterPro
D 1 - 117 Show 3D Structure View in InterPro
G 1 - 117 Show 3D Structure View in InterPro
J 1 - 117 Show 3D Structure View in InterPro
4CDD A 1 - 117 Show 3D Structure View in InterPro
D 1 - 117 Show 3D Structure View in InterPro
4CDE A 1 - 117 Show 3D Structure View in InterPro
D 1 - 117 Show 3D Structure View in InterPro
4CDF A 1 - 117 Show 3D Structure View in InterPro
D 1 - 117 Show 3D Structure View in InterPro
4OEL A 1 - 117 Show 3D Structure View in InterPro
4OEM A 1 - 117 Show 3D Structure View in InterPro
6IC5 A 1 - 117 Show 3D Structure View in InterPro
6IC6 A 1 - 117 Show 3D Structure View in InterPro
6IC7 A 1 - 117 Show 3D Structure View in InterPro
6RN6 A 1 - 117 Show 3D Structure View in InterPro
D 1 - 117 Show 3D Structure View in InterPro
6RN7 A 1 - 117 Show 3D Structure View in InterPro
6RN9 A 1 - 117 Show 3D Structure View in InterPro
6RNE A 1 - 117 Show 3D Structure View in InterPro
6RNI A 1 - 117 Show 3D Structure View in InterPro
Peptidase_C1 231 - 390 4CDE B 207 - 366 Show 3D Structure View in InterPro
231 - 391 2DJF B 207 - 367 Show 3D Structure View in InterPro
2DJG B 207 - 367 Show 3D Structure View in InterPro
4CDC B 207 - 367 Show 3D Structure View in InterPro
E 207 - 367 Show 3D Structure View in InterPro
H 207 - 367 Show 3D Structure View in InterPro
K 207 - 367 Show 3D Structure View in InterPro
4CDD B 207 - 367 Show 3D Structure View in InterPro
E 207 - 367 Show 3D Structure View in InterPro
4CDE E 207 - 367 Show 3D Structure View in InterPro
4CDF B 207 - 367 Show 3D Structure View in InterPro
E 207 - 367 Show 3D Structure View in InterPro
4OEL A 207 - 367 Show 3D Structure View in InterPro
4OEM A 207 - 367 Show 3D Structure View in InterPro
6IC5 B 207 - 367 Show 3D Structure View in InterPro
6IC6 B 207 - 367 Show 3D Structure View in InterPro
6IC7 B 207 - 367 Show 3D Structure View in InterPro
6RN6 B 207 - 367 Show 3D Structure View in InterPro
E 207 - 367 Show 3D Structure View in InterPro
6RN7 B 207 - 367 Show 3D Structure View in InterPro
6RN9 B 207 - 367 Show 3D Structure View in InterPro
6RNE B 207 - 367 Show 3D Structure View in InterPro
6RNI B 207 - 367 Show 3D Structure View in InterPro
231 - 394 1K3B B 207 - 370 Show 3D Structure View in InterPro
231 - 458 3PDF A 207 - 434 Show 3D Structure View in InterPro
395 - 458 1K3B C 371 - 434 Show 3D Structure View in InterPro
396 - 458 2DJF C 372 - 434 Show 3D Structure View in InterPro
2DJG C 372 - 434 Show 3D Structure View in InterPro
4CDC C 372 - 434 Show 3D Structure View in InterPro
F 372 - 434 Show 3D Structure View in InterPro
I 372 - 434 Show 3D Structure View in InterPro
L 372 - 434 Show 3D Structure View in InterPro
4CDD C 372 - 434 Show 3D Structure View in InterPro
F 372 - 434 Show 3D Structure View in InterPro
4CDE C 372 - 434 Show 3D Structure View in InterPro
F 372 - 434 Show 3D Structure View in InterPro
4CDF C 372 - 434 Show 3D Structure View in InterPro
F 372 - 434 Show 3D Structure View in InterPro
4OEL B 372 - 434 Show 3D Structure View in InterPro
6IC5 C 372 - 434 Show 3D Structure View in InterPro
6IC6 C 372 - 434 Show 3D Structure View in InterPro
6IC7 C 372 - 434 Show 3D Structure View in InterPro
6RN6 C 372 - 434 Show 3D Structure View in InterPro
F 372 - 434 Show 3D Structure View in InterPro
6RN7 C 372 - 434 Show 3D Structure View in InterPro
6RN9 C 372 - 434 Show 3D Structure View in InterPro
6RNE C 372 - 434 Show 3D Structure View in InterPro
6RNI C 372 - 434 Show 3D Structure View in InterPro
397 - 458 4OEM B 373 - 434 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;