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1  structure 1  species 0  interactions 1  sequence 1  architecture

Protein: SC24C_HUMAN (P53992)

Summary

This is the summary of UniProt entry SC24C_HUMAN (P53992).

Description: Protein transport protein Sec24C {ECO:0000305}
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 1094 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
disorder n/a 1 350
low_complexity n/a 7 23
low_complexity n/a 22 34
low_complexity n/a 60 77
low_complexity n/a 121 131
low_complexity n/a 273 282
low_complexity n/a 309 324
disorder n/a 357 362
disorder n/a 410 411
Pfam zf-Sec23_Sec24 422 460
Pfam Sec23_trunk 499 743
disorder n/a 659 660
disorder n/a 666 667
Pfam Sec23_BS 748 832
Pfam Sec23_helical 843 945
Pfam Gelsolin 961 1036
disorder n/a 962 970
low_complexity n/a 993 1004
low_complexity n/a 996 1013

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P53992. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MNVNQSVPPV PPFGQPQPIY PGYHQSSYGG QSGSTAPAIP YGAYNGPVPG
50
51
YQQTPPQGMS RAPPSSGAPP ASTAQAPCGQ AAYGQFGQGD VQNGPSSTVQ
100
101
MQRLPGSQPF GSPLAPVGNQ PPVLQPYGPP PTSAQVATQL SGMQISGAVA
150
151
PAPPSSGLGF GPPTSLASAS GSFPNSGLYG SYPQGQAPPL SQAQGHPGIQ
200
201
TPQRSAPSQA SSFTPPASGG PRLPSMTGPL LPGQSFGGPS VSQPNHVSSP
250
251
PQALPPGTQM TGPLGPLPPM HSPQQPGYQP QQNGSFGPAR GPQSNYGGPY
300
301
PAAPTFGSQP GPPQPLPPKR LDPDAIPSPI QVIEDDRNNR GTEPFVTGVR
350
351
GQVPPLVTTN FLVKDQGNAS PRYIRCTSYN IPCTSDMAKQ AQVPLAAVIK
400
401
PLARLPPEEA SPYVVDHGES GPLRCNRCKA YMCPFMQFIE GGRRFQCCFC
450
451
SCINDVPPQY FQHLDHTGKR VDAYDRPELS LGSYEFLATV DYCKNNKFPS
500
501
PPAFIFMIDV SYNAIRTGLV RLLCEELKSL LDFLPREGGA EESAIRVGFV
550
551
TYNKVLHFYN VKSSLAQPQM MVVSDVADMF VPLLDGFLVN VNESRAVITS
600
601
LLDQIPEMFA DTRETETVFV PVIQAGMEAL KAAECAGKLF LFHTSLPIAE
650
651
APGKLKNRDD RKLINTDKEK TLFQPQTGAY QTLAKECVAQ GCCVDLFLFP
700
701
NQYVDVATLS VVPQLTGGSV YKYASFQVEN DQERFLSDLR RDVQKVVGFD
750
751
AVMRVRTSTG IRAVDFFGAF YMSNTTDVEL AGLDGDKTVT VEFKHDDRLN
800
801
EESGALLQCA LLYTSCAGQR RLRIHNLALN CCTQLADLYR NCETDTLINY
850
851
MAKFAYRGVL NSPVKAVRDT LITQCAQILA CYRKNCASPS SAGQLILPEC
900
901
MKLLPVYLNC VLKSDVLQPG AEVTTDDRAY VRQLVTSMDV TETNVFFYPR
950
951
LLPLTKSPVE STTEPPAVRA SEERLSNGDI YLLENGLNLF LWVGASVQQG
1000
1001
VVQSLFSVSS FSQITSGLSV LPVLDNPLSK KVRGLIDSLR AQRSRYMKLT
1050
1051
VVKQEDKMEM LFKHFLVEDK SLSGGASYVD FLCHMHKEIR QLLS      
1094
 

Show the unformatted sequence.

Checksums:
CRC64:5E308E4B8E596ECE
MD5:5ad580a29ed3d6bb2b4601aa5834ad15

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Gelsolin 961 - 1036 3EH2 A 634 - 709 Show 3D Structure View in InterPro
B 634 - 709 Show 3D Structure View in InterPro
C 634 - 709 Show 3D Structure View in InterPro
Sec23_BS 748 - 832 3EH2 A 421 - 505 Show 3D Structure View in InterPro
B 421 - 505 Show 3D Structure View in InterPro
C 421 - 505 Show 3D Structure View in InterPro
Sec23_helical 843 - 945 3EH2 A 516 - 618 Show 3D Structure View in InterPro
B 516 - 618 Show 3D Structure View in InterPro
C 516 - 618 Show 3D Structure View in InterPro
Sec23_trunk 499 - 743 3EH2 A 172 - 416 Show 3D Structure View in InterPro
B 172 - 416 Show 3D Structure View in InterPro
C 172 - 416 Show 3D Structure View in InterPro
zf-Sec23_Sec24 422 - 460 3EH2 A 95 - 133 Show 3D Structure View in InterPro
B 95 - 133 Show 3D Structure View in InterPro
C 95 - 133 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;