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6  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: EPHB1_HUMAN (P54762)

Summary

This is the summary of UniProt entry EPHB1_HUMAN (P54762).

Description: Ephrin type-B receptor 1 EC=2.7.10.1
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 984 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

Download the data used to generate the domain graphic in JSON format.

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Source Domain Start End
sig_p n/a 1 17
low_complexity n/a 2 17
Pfam Ephrin_lbd 20 196
Pfam fn3 324 418
disorder n/a 341 346
low_complexity n/a 360 375
disorder n/a 420 421
disorder n/a 423 427
disorder n/a 429 430
Pfam fn3 434 518
disorder n/a 450 451
disorder n/a 482 488
transmembrane n/a 541 563
Pfam EphA2_TM 542 616
low_complexity n/a 542 562
Pfam PK_Tyr_Ser-Thr 619 878
Pfam SAM_1 909 973

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P54762. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MALDYLLLLL LASAVAAMEE TLMDTRTATA ELGWTANPAS GWEEVSGYDE
50
51
NLNTIRTYQV CNVFEPNQNN WLLTTFINRR GAHRIYTEMR FTVRDCSSLP
100
101
NVPGSCKETF NLYYYETDSV IATKKSAFWS EAPYLKVDTI AADESFSQVD
150
151
FGGRLMKVNT EVRSFGPLTR NGFYLAFQDY GACMSLLSVR VFFKKCPSIV
200
201
QNFAVFPETM TGAESTSLVI ARGTCIPNAE EVDVPIKLYC NGDGEWMVPI
250
251
GRCTCKPGYE PENSVACKAC PAGTFKASQE AEGCSHCPSN SRSPAEASPI
300
301
CTCRTGYYRA DFDPPEVACT SVPSGPRNVI SIVNETSIIL EWHPPRETGG
350
351
RDDVTYNIIC KKCRADRRSC SRCDDNVEFV PRQLGLTECR VSISSLWAHT
400
401
PYTFDIQAIN GVSSKSPFPP QHVSVNITTN QAAPSTVPIM HQVSATMRSI
450
451
TLSWPQPEQP NGIILDYEIR YYEKEHNEFN SSMARSQTNT ARIDGLRPGM
500
501
VYVVQVRART VAGYGKFSGK MCFQTLTDDD YKSELREQLP LIAGSAAAGV
550
551
VFVVSLVAIS IVCSRKRAYS KEAVYSDKLQ HYSTGRGSPG MKIYIDPFTY
600
601
EDPNEAVREF AKEIDVSFVK IEEVIGAGEF GEVYKGRLKL PGKREIYVAI
650
651
KTLKAGYSEK QRRDFLSEAS IMGQFDHPNI IRLEGVVTKS RPVMIITEFM
700
701
ENGALDSFLR QNDGQFTVIQ LVGMLRGIAA GMKYLAEMNY VHRDLAARNI
750
751
LVNSNLVCKV SDFGLSRYLQ DDTSDPTYTS SLGGKIPVRW TAPEAIAYRK
800
801
FTSASDVWSY GIVMWEVMSF GERPYWDMSN QDVINAIEQD YRLPPPMDCP
850
851
AALHQLMLDC WQKDRNSRPR FAEIVNTLDK MIRNPASLKT VATITAVPSQ
900
901
PLLDRSIPDF TAFTTVDDWL SAIKMVQYRD SFLTAGFTSL QLVTQMTSED
950
951
LLRIGITLAG HQKKILNSIH SMRVQISQSP TAMA                 
984
 

Show the unformatted sequence.

Checksums:
CRC64:8044160E24E93A92
MD5:1a8896170fbf6efcc913d02d247690c3

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
EphA2_TM 608 - 616 5MJB A 608 - 616 Show 3D Structure View in InterPro
B 608 - 616 Show 3D Structure View in InterPro
609 - 616 5MJA A 609 - 616 Show 3D Structure View in InterPro
B 609 - 616 Show 3D Structure View in InterPro
611 - 616 3ZFX A 611 - 616 Show 3D Structure View in InterPro
B 611 - 616 Show 3D Structure View in InterPro
D 611 - 616 Show 3D Structure View in InterPro
E 611 - 616 Show 3D Structure View in InterPro
G 611 - 616 Show 3D Structure View in InterPro
H 611 - 616 Show 3D Structure View in InterPro
I 611 - 616 Show 3D Structure View in InterPro
6UMW A 611 - 616 Show 3D Structure View in InterPro
612 - 616 3ZFX F 612 - 616 Show 3D Structure View in InterPro
614 - 616 3ZFX C 614 - 616 Show 3D Structure View in InterPro
fn3 434 - 518 2DJS A 8 - 92 Show 3D Structure View in InterPro
PK_Tyr_Ser-Thr 619 - 878 3ZFX A 619 - 878 Show 3D Structure View in InterPro
B 619 - 878 Show 3D Structure View in InterPro
C 619 - 878 Show 3D Structure View in InterPro
D 619 - 878 Show 3D Structure View in InterPro
E 619 - 878 Show 3D Structure View in InterPro
F 619 - 878 Show 3D Structure View in InterPro
G 619 - 878 Show 3D Structure View in InterPro
H 619 - 878 Show 3D Structure View in InterPro
I 619 - 878 Show 3D Structure View in InterPro
5MJA A 619 - 878 Show 3D Structure View in InterPro
B 619 - 878 Show 3D Structure View in InterPro
5MJB A 619 - 878 Show 3D Structure View in InterPro
B 619 - 878 Show 3D Structure View in InterPro
6UMW A 619 - 878 Show 3D Structure View in InterPro
SAM_1 909 - 973 2EAO A 18 - 82 Show 3D Structure View in InterPro
×

The parts of the structure corresponding to the Pfam family are highlighted in blue.

Loading Structure Data

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.

AlphaFold Structure Prediction

The protein structure below has been predicted by DeepMind with AlphaFold. For more information, please visit the AlphaFold page for this protein.

Model confidence scale

  Very High (pLDDT > 90)
  Confident (90 > pLDDT > 70)
  Low (70 > pLDDT > 50)
  Very Low (pLDDT < 50)
Highly accurate protein structure prediction with AlphaFold. John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli & Demis Hassabis Nature 2021-07-15; DOI: 10.1038/s41586-021-03819-2;