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3  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: PAR2_HUMAN (P55085)

Summary

This is the summary of UniProt entry PAR2_HUMAN (P55085).

Description: Proteinase-activated receptor 2
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
View Pfam proteome data.
Length: 397 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
sig_p n/a 1 22
low_complexity n/a 4 22
transmembrane n/a 76 101
Pfam 7tm_1 92 344
transmembrane n/a 110 130
transmembrane n/a 150 169
transmembrane n/a 190 211
transmembrane n/a 242 264
transmembrane n/a 285 313
transmembrane n/a 325 347
low_complexity n/a 372 395

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P55085. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MRSPSAAWLL GAAILLAASL SCSGTIQGTN RSSKGRSLIG KVDGTSHVTG
50
51
KGVTVETVFS VDEFSASVLT GKLTTVFLPI VYTIVFVVGL PSNGMALWVF
100
101
LFRTKKKHPA VIYMANLALA DLLSVIWFPL KIAYHIHGNN WIYGEALCNV
150
151
LIGFFYGNMY CSILFMTCLS VQRYWVIVNP MGHSRKKANI AIGISLAIWL
200
201
LILLVTIPLY VVKQTIFIPA LNITTCHDVL PEQLLVGDMF NYFLSLAIGV
250
251
FLFPAFLTAS AYVLMIRMLR SSAMDENSEK KRKRAIKLIV TVLAMYLICF
300
301
TPSNLLLVVH YFLIKSQGQS HVYALYIVAL CLSTLNSCID PFVYYFVSHD
350
351
FRDHAKNALL CRSVRTVKQM QVSLTSKKHS RKSSSYSSSS TTVKTSY   
397
 

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Checksums:
CRC64:F1A4E1D5AB9B362B
MD5:de61ab3a2cef66f54e6ffbf202787956

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
7tm_1 92 - 344 5NDD A 92 - 344 Jmol OpenAstexViewer
5NDZ A 92 - 344 Jmol OpenAstexViewer
5NJ6 A 92 - 344 Jmol OpenAstexViewer

TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.