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25  structures 1  species 0  interactions 1  sequence 1  architecture

Protein: CASP6_HUMAN (P55212)

Summary

This is the summary of UniProt entry CASP6_HUMAN (P55212).

Description: Caspase-6
Source organism: Homo sapiens (Human) (NCBI taxonomy ID 9606)
Length: 293 amino acids
Reference Proteome: ✓

Please note: when we start each new Pfam data release, we take a copy of the UniProt sequence database. This snapshot of UniProt forms the basis of the overview that you see here. It is important to note that, although some UniProt entries may be removed after a Pfam release, these entries will not be removed from Pfam until the next Pfam data release.

Pfam domains

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Source Domain Start End
disorder n/a 1 16
disorder n/a 18 19
Pfam Peptidase_C14 44 287

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Sequence information

This is the amino acid sequence of the UniProt sequence database entry with the accession P55212. This sequence is stored in the Pfam database and updated with each new Pfam release, but this means that the sequence we store may differ from that stored by UniProt.

Sequence:
1
MSSASGLRRG HPAGGEENMT ETDAFYKREM FDPAEKYKMD HRRRGIALIF
50
51
NHERFFWHLT LPERRGTCAD RDNLTRRFSD LGFEVKCFND LKAEELLLKI
100
101
HEVSTVSHAD ADCFVCVFLS HGEGNHIYAY DAKIEIQTLT GLFKGDKCHS
150
151
LVGKPKIFII QACRGNQHDV PVIPLDVVDN QTEKLDTNIT EVDAASVYTL
200
201
PAGADFLMCY SVAEGYYSHR ETVNGSWYIQ DLCEMLGKYG SSLEFTELLT
250
251
LVNRKVSQRR VDFCKDPSAI GKKQVPCFAS MLTKKLHFFP KSN       
293
 

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Checksums:
CRC64:0738AE4F9791EBD7
MD5:0154cd5c66753743489b7aedc1771b6f

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe SIFTS project, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between Pfam domains, this UniProt entry and a corresponding three dimensional structure.

Pfam family UniProt residues PDB ID PDB chain ID PDB residues View
Peptidase_C14 198 - 287 3P45 B 198 - 287 NGL View in InterPro
3P4U B 198 - 287 NGL View in InterPro
D 198 - 287 NGL View in InterPro
200 - 287 3P45 D 200 - 287 NGL View in InterPro
H 200 - 287 NGL View in InterPro
3QNW B 200 - 287 NGL View in InterPro
D 200 - 287 NGL View in InterPro
201 - 287 3P45 J 201 - 287 NGL View in InterPro
P 201 - 287 NGL View in InterPro
202 - 287 3P45 F 202 - 287 NGL View in InterPro
L 202 - 287 NGL View in InterPro
N 202 - 287 NGL View in InterPro
3QNW F 202 - 287 NGL View in InterPro
H 202 - 287 NGL View in InterPro
44 - 162 3P45 C 44 - 162 NGL View in InterPro
E 44 - 162 NGL View in InterPro
G 44 - 162 NGL View in InterPro
O 44 - 162 NGL View in InterPro
44 - 163 3P45 A 44 - 163 NGL View in InterPro
I 44 - 163 NGL View in InterPro
K 44 - 163 NGL View in InterPro
M 44 - 163 NGL View in InterPro
3QNW C 44 - 163 NGL View in InterPro
E 44 - 163 NGL View in InterPro
G 44 - 163 NGL View in InterPro
44 - 164 3QNW A 44 - 164 NGL View in InterPro
44 - 175 3P4U A 44 - 175 NGL View in InterPro
C 44 - 175 NGL View in InterPro
44 - 287 2WDP A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
C 44 - 287 NGL View in InterPro
D 44 - 287 NGL View in InterPro
3K7E A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
C 44 - 287 NGL View in InterPro
D 44 - 287 NGL View in InterPro
3NKF A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
C 44 - 287 NGL View in InterPro
D 44 - 287 NGL View in InterPro
3NR2 A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
3OD5 A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
3S70 A 44 - 287 NGL View in InterPro
C 44 - 287 NGL View in InterPro
3S8E A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
C 44 - 287 NGL View in InterPro
D 44 - 287 NGL View in InterPro
E 44 - 287 NGL View in InterPro
F 44 - 287 NGL View in InterPro
G 44 - 287 NGL View in InterPro
H 44 - 287 NGL View in InterPro
3V6L A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
3V6M A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
C 44 - 287 NGL View in InterPro
D 44 - 287 NGL View in InterPro
F 44 - 287 NGL View in InterPro
G 44 - 287 NGL View in InterPro
I 44 - 287 NGL View in InterPro
J 44 - 287 NGL View in InterPro
4EJF A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
C 44 - 287 NGL View in InterPro
D 44 - 287 NGL View in InterPro
4FXO A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
C 44 - 287 NGL View in InterPro
D 44 - 287 NGL View in InterPro
4HVA A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
4IYR A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
4N5D A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
4N6G A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
4N7J A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
4N7M A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
4NBK A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
4NBL A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
4NBN A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
6DEU A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
6DEV A 44 - 287 NGL View in InterPro
B 44 - 287 NGL View in InterPro
C 44 - 287 NGL View in InterPro
D 44 - 287 NGL View in InterPro
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TreeFam

Below is a phylogenetic tree of animal genes, with ortholog and paralog assignments, from TreeFam.